Performance analysis of noninvasive electrophysiological methods for the assessment of diabetic sensorimotor polyneuropathy in clinical research: a systematic review and meta-analysis with trial sequential analysis

Abstract Despite the availability of various clinical trials that used different diagnostic methods to identify diabetic sensorimotor polyneuropathy (DSPN), no reliable studies that prove the associations among diagnostic parameters from two different methods are available. Statistically significant...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fahmida Haque, Mamun Bin Ibne Reaz, Sawal Hamid Md Ali, Norhana Arsad, Muhammad Enamul Hoque Chowdhury
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2c74df4df0b943de8546dc5663b682f9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2c74df4df0b943de8546dc5663b682f9
record_format	dspace
spelling	oai:doaj.org-article:2c74df4df0b943de8546dc5663b682f92021-12-02T12:33:14ZPerformance analysis of noninvasive electrophysiological methods for the assessment of diabetic sensorimotor polyneuropathy in clinical research: a systematic review and meta-analysis with trial sequential analysis10.1038/s41598-020-78787-02045-2322https://doaj.org/article/2c74df4df0b943de8546dc5663b682f92020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78787-0https://doaj.org/toc/2045-2322Abstract Despite the availability of various clinical trials that used different diagnostic methods to identify diabetic sensorimotor polyneuropathy (DSPN), no reliable studies that prove the associations among diagnostic parameters from two different methods are available. Statistically significant diagnostic parameters from various methods can help determine if two different methods can be incorporated together for diagnosing DSPN. In this study, a systematic review, meta-analysis, and trial sequential analysis (TSA) were performed to determine the associations among the different parameters from the most commonly used electrophysiological screening methods in clinical research for DSPN, namely, nerve conduction study (NCS), corneal confocal microscopy (CCM), and electromyography (EMG), for different experimental groups. Electronic databases (e.g., Web of Science, PubMed, and Google Scholar) were searched systematically for articles reporting different screening tools for diabetic peripheral neuropathy. A total of 22 studies involving 2394 participants (801 patients with DSPN, 702 controls, and 891 non-DSPN patients) were reviewed systematically. Meta-analysis was performed to determine statistical significance of difference among four NCS parameters, i.e., peroneal motor nerve conduction velocity, peroneal motor nerve amplitude, sural sensory nerve conduction velocity, and sural sensory nerve amplitude (all p < 0.001); among three CCM parameters, including nerve fiber density, nerve branch density, and nerve fiber length (all p < 0.001); and among four EMG parameters, namely, time to peak occurrence (from 0 to 100% of the stance phase) of four lower limb muscles, including the vastus lateralis (p < 0.001), tibialis anterior (p = 0.63), lateral gastrocnemius (p = 0.01), and gastrocnemius medialis (p = 0.004), and the vibration perception threshold (p < 0.001). Moreover, TSA was conducted to estimate the robustness of the meta-analysis. Most of the parameters showed statistical significance between each other, whereas some were statistically nonsignificant. This meta-analysis and TSA concluded that studies including NCS and CCM parameters were conclusive and robust. However, the included studies on EMG were inconclusive, and additional clinical trials are required.Fahmida HaqueMamun Bin Ibne ReazSawal Hamid Md AliNorhana ArsadMuhammad Enamul Hoque ChowdhuryNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fahmida Haque Mamun Bin Ibne Reaz Sawal Hamid Md Ali Norhana Arsad Muhammad Enamul Hoque Chowdhury Performance analysis of noninvasive electrophysiological methods for the assessment of diabetic sensorimotor polyneuropathy in clinical research: a systematic review and meta-analysis with trial sequential analysis
description	Abstract Despite the availability of various clinical trials that used different diagnostic methods to identify diabetic sensorimotor polyneuropathy (DSPN), no reliable studies that prove the associations among diagnostic parameters from two different methods are available. Statistically significant diagnostic parameters from various methods can help determine if two different methods can be incorporated together for diagnosing DSPN. In this study, a systematic review, meta-analysis, and trial sequential analysis (TSA) were performed to determine the associations among the different parameters from the most commonly used electrophysiological screening methods in clinical research for DSPN, namely, nerve conduction study (NCS), corneal confocal microscopy (CCM), and electromyography (EMG), for different experimental groups. Electronic databases (e.g., Web of Science, PubMed, and Google Scholar) were searched systematically for articles reporting different screening tools for diabetic peripheral neuropathy. A total of 22 studies involving 2394 participants (801 patients with DSPN, 702 controls, and 891 non-DSPN patients) were reviewed systematically. Meta-analysis was performed to determine statistical significance of difference among four NCS parameters, i.e., peroneal motor nerve conduction velocity, peroneal motor nerve amplitude, sural sensory nerve conduction velocity, and sural sensory nerve amplitude (all p < 0.001); among three CCM parameters, including nerve fiber density, nerve branch density, and nerve fiber length (all p < 0.001); and among four EMG parameters, namely, time to peak occurrence (from 0 to 100% of the stance phase) of four lower limb muscles, including the vastus lateralis (p < 0.001), tibialis anterior (p = 0.63), lateral gastrocnemius (p = 0.01), and gastrocnemius medialis (p = 0.004), and the vibration perception threshold (p < 0.001). Moreover, TSA was conducted to estimate the robustness of the meta-analysis. Most of the parameters showed statistical significance between each other, whereas some were statistically nonsignificant. This meta-analysis and TSA concluded that studies including NCS and CCM parameters were conclusive and robust. However, the included studies on EMG were inconclusive, and additional clinical trials are required.
format	article
author	Fahmida Haque Mamun Bin Ibne Reaz Sawal Hamid Md Ali Norhana Arsad Muhammad Enamul Hoque Chowdhury
author_facet	Fahmida Haque Mamun Bin Ibne Reaz Sawal Hamid Md Ali Norhana Arsad Muhammad Enamul Hoque Chowdhury
author_sort	Fahmida Haque
title	Performance analysis of noninvasive electrophysiological methods for the assessment of diabetic sensorimotor polyneuropathy in clinical research: a systematic review and meta-analysis with trial sequential analysis
title_short	Performance analysis of noninvasive electrophysiological methods for the assessment of diabetic sensorimotor polyneuropathy in clinical research: a systematic review and meta-analysis with trial sequential analysis
title_full	Performance analysis of noninvasive electrophysiological methods for the assessment of diabetic sensorimotor polyneuropathy in clinical research: a systematic review and meta-analysis with trial sequential analysis
title_fullStr	Performance analysis of noninvasive electrophysiological methods for the assessment of diabetic sensorimotor polyneuropathy in clinical research: a systematic review and meta-analysis with trial sequential analysis
title_full_unstemmed	Performance analysis of noninvasive electrophysiological methods for the assessment of diabetic sensorimotor polyneuropathy in clinical research: a systematic review and meta-analysis with trial sequential analysis
title_sort	performance analysis of noninvasive electrophysiological methods for the assessment of diabetic sensorimotor polyneuropathy in clinical research: a systematic review and meta-analysis with trial sequential analysis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2c74df4df0b943de8546dc5663b682f9
work_keys_str_mv	AT fahmidahaque performanceanalysisofnoninvasiveelectrophysiologicalmethodsfortheassessmentofdiabeticsensorimotorpolyneuropathyinclinicalresearchasystematicreviewandmetaanalysiswithtrialsequentialanalysis AT mamunbinibnereaz performanceanalysisofnoninvasiveelectrophysiologicalmethodsfortheassessmentofdiabeticsensorimotorpolyneuropathyinclinicalresearchasystematicreviewandmetaanalysiswithtrialsequentialanalysis AT sawalhamidmdali performanceanalysisofnoninvasiveelectrophysiologicalmethodsfortheassessmentofdiabeticsensorimotorpolyneuropathyinclinicalresearchasystematicreviewandmetaanalysiswithtrialsequentialanalysis AT norhanaarsad performanceanalysisofnoninvasiveelectrophysiologicalmethodsfortheassessmentofdiabeticsensorimotorpolyneuropathyinclinicalresearchasystematicreviewandmetaanalysiswithtrialsequentialanalysis AT muhammadenamulhoquechowdhury performanceanalysisofnoninvasiveelectrophysiologicalmethodsfortheassessmentofdiabeticsensorimotorpolyneuropathyinclinicalresearchasystematicreviewandmetaanalysiswithtrialsequentialanalysis
_version_	1718393849454264320

Performance analysis of noninvasive electrophysiological methods for the assessment of diabetic sensorimotor polyneuropathy in clinical research: a systematic review and meta-analysis with trial sequential analysis

Ejemplares similares