Drug-Induced Intersticial Nephritis. Clinical Case

5-Aminosalicylic acid (5-ASA) preparations are widely used in the treatment of inflammatory bowel diseases. The most commonly used medicine is mesalamine. Overall, it is a very safe drug with few side effects. A rare side effect of this medicine is interstitial nephritis (IN). With discontinuation...

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Autores principales: Paulina Tekoriutė, Monika Matuliauskaitė, Laimas Virginijus Jonaitis
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Lenguaje:EN
Publicado: Vilnius University Press 2021
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Acceso en línea:https://doaj.org/article/2c76ebc02b0e4f15b714665178a2dd6f
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spelling oai:doaj.org-article:2c76ebc02b0e4f15b714665178a2dd6f2021-11-09T09:30:05ZDrug-Induced Intersticial Nephritis. Clinical Case10.15388/Amed.2021.28.2.141392-01382029-4174https://doaj.org/article/2c76ebc02b0e4f15b714665178a2dd6f2021-11-01T00:00:00Zhttps://www.journals.vu.lt/AML/article/view/24614https://doaj.org/toc/1392-0138https://doaj.org/toc/2029-4174 5-Aminosalicylic acid (5-ASA) preparations are widely used in the treatment of inflammatory bowel diseases. The most commonly used medicine is mesalamine. Overall, it is a very safe drug with few side effects. A rare side effect of this medicine is interstitial nephritis (IN). With discontinuation of the drug the renal function usually restores. However, if damage has not been detected for a long time, irreversible changes may occur. In this article, we present a clinical case of mesalamine induced IN. A 56-year-old man who has had ulcerative colitis for 20 years, was admitted due to mesalamine induced acute renal failure. A year before, the patient had been diagnosed with mesalamine-induced interstitial nephritis and the treatment with mesalamine was discontinued. The symptoms of ulcerative colitis worsened, and the patient independently decided to start taking mesalamine, which resulted in worsening of his health condition and impaired renal function. Mesalamine has been discontinued, additional treatment for acute kidney failure has been administered including hemodialysis. Renal function recovered and the patient was released for further treatment of ulcerative colitis and monitoring of renal function. Paulina TekoriutėMonika MatuliauskaitėLaimas Virginijus JonaitisVilnius University Pressarticlemesalamineinterstitial nephritisulcerative colitisMedicineRENActa Medica Lituanica, Vol 28, Iss 2 (2021)
institution DOAJ
collection DOAJ
language EN
topic mesalamine
interstitial nephritis
ulcerative colitis
Medicine
R
spellingShingle mesalamine
interstitial nephritis
ulcerative colitis
Medicine
R
Paulina Tekoriutė
Monika Matuliauskaitė
Laimas Virginijus Jonaitis
Drug-Induced Intersticial Nephritis. Clinical Case
description 5-Aminosalicylic acid (5-ASA) preparations are widely used in the treatment of inflammatory bowel diseases. The most commonly used medicine is mesalamine. Overall, it is a very safe drug with few side effects. A rare side effect of this medicine is interstitial nephritis (IN). With discontinuation of the drug the renal function usually restores. However, if damage has not been detected for a long time, irreversible changes may occur. In this article, we present a clinical case of mesalamine induced IN. A 56-year-old man who has had ulcerative colitis for 20 years, was admitted due to mesalamine induced acute renal failure. A year before, the patient had been diagnosed with mesalamine-induced interstitial nephritis and the treatment with mesalamine was discontinued. The symptoms of ulcerative colitis worsened, and the patient independently decided to start taking mesalamine, which resulted in worsening of his health condition and impaired renal function. Mesalamine has been discontinued, additional treatment for acute kidney failure has been administered including hemodialysis. Renal function recovered and the patient was released for further treatment of ulcerative colitis and monitoring of renal function.
format article
author Paulina Tekoriutė
Monika Matuliauskaitė
Laimas Virginijus Jonaitis
author_facet Paulina Tekoriutė
Monika Matuliauskaitė
Laimas Virginijus Jonaitis
author_sort Paulina Tekoriutė
title Drug-Induced Intersticial Nephritis. Clinical Case
title_short Drug-Induced Intersticial Nephritis. Clinical Case
title_full Drug-Induced Intersticial Nephritis. Clinical Case
title_fullStr Drug-Induced Intersticial Nephritis. Clinical Case
title_full_unstemmed Drug-Induced Intersticial Nephritis. Clinical Case
title_sort drug-induced intersticial nephritis. clinical case
publisher Vilnius University Press
publishDate 2021
url https://doaj.org/article/2c76ebc02b0e4f15b714665178a2dd6f
work_keys_str_mv AT paulinatekoriute druginducedintersticialnephritisclinicalcase
AT monikamatuliauskaite druginducedintersticialnephritisclinicalcase
AT laimasvirginijusjonaitis druginducedintersticialnephritisclinicalcase
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