Mycosins of the Mycobacterial Type VII ESX Secretion System: the Glue That Holds the Party Together

ABSTRACT Since their discovery as important determinants of virulence and growth, the type VII ESX secretion systems (ESX-1 to ESX-5) of slow-growing pathogenic mycobacteria have been the focus of intense scrutiny. Genetic studies have been instrumental in identifying the core components and substra...

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Autor principal:	Jeffrey M. Chen
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2c7dfe8a9e8743d4aa0aa718cfb229de
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spelling	oai:doaj.org-article:2c7dfe8a9e8743d4aa0aa718cfb229de2021-11-15T15:50:17ZMycosins of the Mycobacterial Type VII ESX Secretion System: the Glue That Holds the Party Together10.1128/mBio.02062-162150-7511https://doaj.org/article/2c7dfe8a9e8743d4aa0aa718cfb229de2016-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02062-16https://doaj.org/toc/2150-7511ABSTRACT Since their discovery as important determinants of virulence and growth, the type VII ESX secretion systems (ESX-1 to ESX-5) of slow-growing pathogenic mycobacteria have been the focus of intense scrutiny. Genetic studies have been instrumental in identifying the core components and substrates of these molecular secretion machines and have helped uncover the multifunctional properties of some of them. For instance, the mycosin MycP1 of ESX-1, a membrane-associated subtilisin-like serine protease, was shown to have dual functions: the entire protein is essential for ESX-1 function, but only the serine protease regulates secretion activity. MycP5 of ESX-5, on the other hand, is required for ESX-5 secretion activity, but the function of its predicted serine protease remains unknown. Recently, van Winden and colleagues (mBio 7:e01471-16, 2016, http://dx.doi.org/10.1128/mBio.01471-16) reported compelling evidence that MycP1 and MycP5 serve to stabilize the interactions of core ESX-1 and ESX-5 components, respectively, thus explaining how they facilitate the secretion activities of their associated systems.Jeffrey M. ChenAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 6 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Jeffrey M. Chen Mycosins of the Mycobacterial Type VII ESX Secretion System: the Glue That Holds the Party Together
description	ABSTRACT Since their discovery as important determinants of virulence and growth, the type VII ESX secretion systems (ESX-1 to ESX-5) of slow-growing pathogenic mycobacteria have been the focus of intense scrutiny. Genetic studies have been instrumental in identifying the core components and substrates of these molecular secretion machines and have helped uncover the multifunctional properties of some of them. For instance, the mycosin MycP1 of ESX-1, a membrane-associated subtilisin-like serine protease, was shown to have dual functions: the entire protein is essential for ESX-1 function, but only the serine protease regulates secretion activity. MycP5 of ESX-5, on the other hand, is required for ESX-5 secretion activity, but the function of its predicted serine protease remains unknown. Recently, van Winden and colleagues (mBio 7:e01471-16, 2016, http://dx.doi.org/10.1128/mBio.01471-16) reported compelling evidence that MycP1 and MycP5 serve to stabilize the interactions of core ESX-1 and ESX-5 components, respectively, thus explaining how they facilitate the secretion activities of their associated systems.
format	article
author	Jeffrey M. Chen
author_facet	Jeffrey M. Chen
author_sort	Jeffrey M. Chen
title	Mycosins of the Mycobacterial Type VII ESX Secretion System: the Glue That Holds the Party Together
title_short	Mycosins of the Mycobacterial Type VII ESX Secretion System: the Glue That Holds the Party Together
title_full	Mycosins of the Mycobacterial Type VII ESX Secretion System: the Glue That Holds the Party Together
title_fullStr	Mycosins of the Mycobacterial Type VII ESX Secretion System: the Glue That Holds the Party Together
title_full_unstemmed	Mycosins of the Mycobacterial Type VII ESX Secretion System: the Glue That Holds the Party Together
title_sort	mycosins of the mycobacterial type vii esx secretion system: the glue that holds the party together
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/2c7dfe8a9e8743d4aa0aa718cfb229de
work_keys_str_mv	AT jeffreymchen mycosinsofthemycobacterialtypeviiesxsecretionsystemthegluethatholdsthepartytogether
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Mycosins of the Mycobacterial Type VII ESX Secretion System: the Glue That Holds the Party Together

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