The Effect of Therapeutic Hypothermia after Cardiac Arrest on the Neurological Outcome and Survival—A Systematic Review of RCTs Published between 2016 and 2020

Therapeutic hypothermia is a treatment used for patients who have suffered cardiorespiratory arrest and remain conscious after the recovery of spontaneous circulation. However, its effectiveness is controversial. The objective of this systematic review is to summarize the scientific evidence availab...

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Autores principales:	Christian Colls Garrido, Blanca Riquelme Gallego, Juan Carlos Sánchez García, Jonathan Cortés Martín, María Montiel Troya, Raquel Rodríguez Blanque
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	induced hypothermia cardiac arrest survival rate critical care Medicine R
Acceso en línea:	https://doaj.org/article/2c7e6b727a4941f28225268d9f37c589
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spelling	oai:doaj.org-article:2c7e6b727a4941f28225268d9f37c5892021-11-25T17:48:39ZThe Effect of Therapeutic Hypothermia after Cardiac Arrest on the Neurological Outcome and Survival—A Systematic Review of RCTs Published between 2016 and 202010.3390/ijerph1822118171660-46011661-7827https://doaj.org/article/2c7e6b727a4941f28225268d9f37c5892021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/11817https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Therapeutic hypothermia is a treatment used for patients who have suffered cardiorespiratory arrest and remain conscious after the recovery of spontaneous circulation. However, its effectiveness is controversial. The objective of this systematic review is to summarize the scientific evidence available about the effect of therapeutic hypothermia on neurological status and survival in this type of patients. Methodology: A primary search in CINAHL, CUIDEN, Pubmed, Web of Science, and Scopus databases was carried out. Randomized clinical trials (RCT) published from 2016 to 2020 were selected. Results: 17 studies were selected for inclusion and most relevant data were extracted. Methodological quality was assessed by the RoB tool. Conclusions: Although therapeutic hypothermia is a safe technique with few adverse and manageable effects, it has not shown to improve survival rate and neurological status of adult nor pediatric patients. It is possible that its positive effect on neuroprotection could be achieved only by preventing hyperthermia although further investigation is needed.Christian Colls GarridoBlanca Riquelme GallegoJuan Carlos Sánchez GarcíaJonathan Cortés MartínMaría Montiel TroyaRaquel Rodríguez BlanqueMDPI AGarticleinduced hypothermiacardiac arrestsurvival ratecritical careMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11817, p 11817 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	induced hypothermia cardiac arrest survival rate critical care Medicine R
spellingShingle	induced hypothermia cardiac arrest survival rate critical care Medicine R Christian Colls Garrido Blanca Riquelme Gallego Juan Carlos Sánchez García Jonathan Cortés Martín María Montiel Troya Raquel Rodríguez Blanque The Effect of Therapeutic Hypothermia after Cardiac Arrest on the Neurological Outcome and Survival—A Systematic Review of RCTs Published between 2016 and 2020
description	Therapeutic hypothermia is a treatment used for patients who have suffered cardiorespiratory arrest and remain conscious after the recovery of spontaneous circulation. However, its effectiveness is controversial. The objective of this systematic review is to summarize the scientific evidence available about the effect of therapeutic hypothermia on neurological status and survival in this type of patients. Methodology: A primary search in CINAHL, CUIDEN, Pubmed, Web of Science, and Scopus databases was carried out. Randomized clinical trials (RCT) published from 2016 to 2020 were selected. Results: 17 studies were selected for inclusion and most relevant data were extracted. Methodological quality was assessed by the RoB tool. Conclusions: Although therapeutic hypothermia is a safe technique with few adverse and manageable effects, it has not shown to improve survival rate and neurological status of adult nor pediatric patients. It is possible that its positive effect on neuroprotection could be achieved only by preventing hyperthermia although further investigation is needed.
format	article
author	Christian Colls Garrido Blanca Riquelme Gallego Juan Carlos Sánchez García Jonathan Cortés Martín María Montiel Troya Raquel Rodríguez Blanque
author_facet	Christian Colls Garrido Blanca Riquelme Gallego Juan Carlos Sánchez García Jonathan Cortés Martín María Montiel Troya Raquel Rodríguez Blanque
author_sort	Christian Colls Garrido
title	The Effect of Therapeutic Hypothermia after Cardiac Arrest on the Neurological Outcome and Survival—A Systematic Review of RCTs Published between 2016 and 2020
title_short	The Effect of Therapeutic Hypothermia after Cardiac Arrest on the Neurological Outcome and Survival—A Systematic Review of RCTs Published between 2016 and 2020
title_full	The Effect of Therapeutic Hypothermia after Cardiac Arrest on the Neurological Outcome and Survival—A Systematic Review of RCTs Published between 2016 and 2020
title_fullStr	The Effect of Therapeutic Hypothermia after Cardiac Arrest on the Neurological Outcome and Survival—A Systematic Review of RCTs Published between 2016 and 2020
title_full_unstemmed	The Effect of Therapeutic Hypothermia after Cardiac Arrest on the Neurological Outcome and Survival—A Systematic Review of RCTs Published between 2016 and 2020
title_sort	effect of therapeutic hypothermia after cardiac arrest on the neurological outcome and survival—a systematic review of rcts published between 2016 and 2020
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2c7e6b727a4941f28225268d9f37c589
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The Effect of Therapeutic Hypothermia after Cardiac Arrest on the Neurological Outcome and Survival—A Systematic Review of RCTs Published between 2016 and 2020

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