Loss of X-linked Protocadherin-19 differentially affects the behavior of heterozygous female and hemizygous male mice

Loss of X-linked Protocadherin-19 differentially affects the behavior of heterozygous female and hemizygous male mice

Abstract Mutations in the X-linked gene Protocadherin-19 (Pcdh19) cause female-limited epilepsy and mental retardation in humans. Although Pcdh19 is known to be a homophilic cell-cell adhesion molecule, how its mutations bring about female-specific disorders remains elusive. Here, we report the effe...

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Autores principales: Shuichi Hayashi, Yoko Inoue, Satoko Hattori, Mari Kaneko, Go Shioi, Tsuyoshi Miyakawa, Masatoshi Takeichi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
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Acceso en línea:https://doaj.org/article/2c80289a658c41e5abfec08cd1b0f138
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