Virucidal Activity of Plant Extracts against African Swine Fever Virus

African swine fever is one of the most dangerous and fatal swine diseases, described for the first time roughly a hundred years ago. Even now, there is neither a commercially approved vaccine nor treatment available. The only way to hinder further spread of the disease is by culling the affected her...

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Autores principales:	Małgorzata Juszkiewicz, Marek Walczak, Grzegorz Woźniakowski, Anna Szczotka-Bochniarz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	African swine fever disinfection plant extracts Medicine R
Acceso en línea:	https://doaj.org/article/2c824a0af25546dea2edbdff02258bcf
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spelling	oai:doaj.org-article:2c824a0af25546dea2edbdff02258bcf2021-11-25T18:37:33ZVirucidal Activity of Plant Extracts against African Swine Fever Virus10.3390/pathogens101113572076-0817https://doaj.org/article/2c824a0af25546dea2edbdff02258bcf2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1357https://doaj.org/toc/2076-0817African swine fever is one of the most dangerous and fatal swine diseases, described for the first time roughly a hundred years ago. Even now, there is neither a commercially approved vaccine nor treatment available. The only way to hinder further spread of the disease is by culling the affected herds and applying prevention based mainly on proper biosecurity. Due to growing awareness of the potential ASF threat among pig producers, disinfection processes are considered as one of the most important preventive measures. Currently, a variety of chemical compounds are applied for the disinfection of pig farms. Meanwhile, these chemicals may pose a potential risk, due to their toxic, irritant or corrosive effect. The aim of this study was to determine whether any plant-based natural compounds may show a virucidal effect against ASFV, and simultaneously be depleted of some of the side-effects typical for chemical compounds. Ideally, natural virucidal compounds should be safe for both humans and animals, biodegradable, easily available and inexpensive. Fourteen plant extracts were selected and screened for their virucidal effect against ASFV, using the suspension test inspired by the PN-EN 14675:2015 European Standard procedure. The results of our study showed that most of the tested plant extracts were ineffective against ASFV. Some extracts suspended in a hydroglycolic medium exhibited high virus titre reduction, but it was confirmed that the effect resulted from medium composition. However, a 1.05% peppermint extract showed high effectiveness against ASFV, reducing the virus titre by ≥4 log<sub>10</sub>, thus demonstrating that natural compounds used as virucidal agents could potentially be used in disinfection procedures, being both effective and harmless to humans and animals.Małgorzata JuszkiewiczMarek WalczakGrzegorz WoźniakowskiAnna Szczotka-BochniarzMDPI AGarticleAfrican swine feverdisinfectionplant extractsMedicineRENPathogens, Vol 10, Iss 1357, p 1357 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	African swine fever disinfection plant extracts Medicine R
spellingShingle	African swine fever disinfection plant extracts Medicine R Małgorzata Juszkiewicz Marek Walczak Grzegorz Woźniakowski Anna Szczotka-Bochniarz Virucidal Activity of Plant Extracts against African Swine Fever Virus
description	African swine fever is one of the most dangerous and fatal swine diseases, described for the first time roughly a hundred years ago. Even now, there is neither a commercially approved vaccine nor treatment available. The only way to hinder further spread of the disease is by culling the affected herds and applying prevention based mainly on proper biosecurity. Due to growing awareness of the potential ASF threat among pig producers, disinfection processes are considered as one of the most important preventive measures. Currently, a variety of chemical compounds are applied for the disinfection of pig farms. Meanwhile, these chemicals may pose a potential risk, due to their toxic, irritant or corrosive effect. The aim of this study was to determine whether any plant-based natural compounds may show a virucidal effect against ASFV, and simultaneously be depleted of some of the side-effects typical for chemical compounds. Ideally, natural virucidal compounds should be safe for both humans and animals, biodegradable, easily available and inexpensive. Fourteen plant extracts were selected and screened for their virucidal effect against ASFV, using the suspension test inspired by the PN-EN 14675:2015 European Standard procedure. The results of our study showed that most of the tested plant extracts were ineffective against ASFV. Some extracts suspended in a hydroglycolic medium exhibited high virus titre reduction, but it was confirmed that the effect resulted from medium composition. However, a 1.05% peppermint extract showed high effectiveness against ASFV, reducing the virus titre by ≥4 log<sub>10</sub>, thus demonstrating that natural compounds used as virucidal agents could potentially be used in disinfection procedures, being both effective and harmless to humans and animals.
format	article
author	Małgorzata Juszkiewicz Marek Walczak Grzegorz Woźniakowski Anna Szczotka-Bochniarz
author_facet	Małgorzata Juszkiewicz Marek Walczak Grzegorz Woźniakowski Anna Szczotka-Bochniarz
author_sort	Małgorzata Juszkiewicz
title	Virucidal Activity of Plant Extracts against African Swine Fever Virus
title_short	Virucidal Activity of Plant Extracts against African Swine Fever Virus
title_full	Virucidal Activity of Plant Extracts against African Swine Fever Virus
title_fullStr	Virucidal Activity of Plant Extracts against African Swine Fever Virus
title_full_unstemmed	Virucidal Activity of Plant Extracts against African Swine Fever Virus
title_sort	virucidal activity of plant extracts against african swine fever virus
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2c824a0af25546dea2edbdff02258bcf
work_keys_str_mv	AT małgorzatajuszkiewicz virucidalactivityofplantextractsagainstafricanswinefevervirus AT marekwalczak virucidalactivityofplantextractsagainstafricanswinefevervirus AT grzegorzwozniakowski virucidalactivityofplantextractsagainstafricanswinefevervirus AT annaszczotkabochniarz virucidalactivityofplantextractsagainstafricanswinefevervirus
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Virucidal Activity of Plant Extracts against African Swine Fever Virus

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