Naringin Exhibited Therapeutic Effects against DSS-Induced Mice Ulcerative Colitis in Intestinal Barrier–Dependent Manner

Naringin is a kind of multi-source food additive which has been explored broadly for its various biological activities and therapeutic potential. In the present study, the protective effect and mechanism of naringin on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice were investi...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ruige Cao, Xing Wu, Hui Guo, Xin Pan, Rong Huang, Gangqiang Wang, Jikai Liu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ulcerative colitis naringin intestinal microbiota inflammation Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/2c829e2ece114bbabac99089205388e1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2c829e2ece114bbabac99089205388e1
record_format	dspace
spelling	oai:doaj.org-article:2c829e2ece114bbabac99089205388e12021-11-11T18:34:36ZNaringin Exhibited Therapeutic Effects against DSS-Induced Mice Ulcerative Colitis in Intestinal Barrier–Dependent Manner10.3390/molecules262166041420-3049https://doaj.org/article/2c829e2ece114bbabac99089205388e12021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6604https://doaj.org/toc/1420-3049Naringin is a kind of multi-source food additive which has been explored broadly for its various biological activities and therapeutic potential. In the present study, the protective effect and mechanism of naringin on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice were investigated. The results showed that naringin significantly alleviated DSS-induced colitis symptoms, including disease activity index (DAI), colon length shortening, and colon pathological damage. The tissue and serum secretion of inflammatory cytokines, as well as the oxidative stress, were decreased accordingly upon naringin intervention. Naringin also decreased the proteins involved in inflammation and increased the expression of tight junction (TJ) proteins. Moreover, naringin increased the relative abundance of <i>Firmicutes</i>/<i>Bacteroides</i> and reduced the content of <i>Proteobacteria</i> to improve the intestinal flora disorder caused by DSS, which promotes the intestinal health of mice. It was concluded that naringin can significantly ameliorate the pathogenic symptoms of UC through inhibiting inflammatory response and regulating intestinal microbiota, which might be a promising natural therapeutic agent for the dietary treatment of UC and the improvement of intestinal symbiosis.Ruige CaoXing WuHui GuoXin PanRong HuangGangqiang WangJikai LiuMDPI AGarticleulcerative colitisnaringinintestinal microbiotainflammationOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6604, p 6604 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ulcerative colitis naringin intestinal microbiota inflammation Organic chemistry QD241-441
spellingShingle	ulcerative colitis naringin intestinal microbiota inflammation Organic chemistry QD241-441 Ruige Cao Xing Wu Hui Guo Xin Pan Rong Huang Gangqiang Wang Jikai Liu Naringin Exhibited Therapeutic Effects against DSS-Induced Mice Ulcerative Colitis in Intestinal Barrier–Dependent Manner
description	Naringin is a kind of multi-source food additive which has been explored broadly for its various biological activities and therapeutic potential. In the present study, the protective effect and mechanism of naringin on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice were investigated. The results showed that naringin significantly alleviated DSS-induced colitis symptoms, including disease activity index (DAI), colon length shortening, and colon pathological damage. The tissue and serum secretion of inflammatory cytokines, as well as the oxidative stress, were decreased accordingly upon naringin intervention. Naringin also decreased the proteins involved in inflammation and increased the expression of tight junction (TJ) proteins. Moreover, naringin increased the relative abundance of <i>Firmicutes</i>/<i>Bacteroides</i> and reduced the content of <i>Proteobacteria</i> to improve the intestinal flora disorder caused by DSS, which promotes the intestinal health of mice. It was concluded that naringin can significantly ameliorate the pathogenic symptoms of UC through inhibiting inflammatory response and regulating intestinal microbiota, which might be a promising natural therapeutic agent for the dietary treatment of UC and the improvement of intestinal symbiosis.
format	article
author	Ruige Cao Xing Wu Hui Guo Xin Pan Rong Huang Gangqiang Wang Jikai Liu
author_facet	Ruige Cao Xing Wu Hui Guo Xin Pan Rong Huang Gangqiang Wang Jikai Liu
author_sort	Ruige Cao
title	Naringin Exhibited Therapeutic Effects against DSS-Induced Mice Ulcerative Colitis in Intestinal Barrier–Dependent Manner
title_short	Naringin Exhibited Therapeutic Effects against DSS-Induced Mice Ulcerative Colitis in Intestinal Barrier–Dependent Manner
title_full	Naringin Exhibited Therapeutic Effects against DSS-Induced Mice Ulcerative Colitis in Intestinal Barrier–Dependent Manner
title_fullStr	Naringin Exhibited Therapeutic Effects against DSS-Induced Mice Ulcerative Colitis in Intestinal Barrier–Dependent Manner
title_full_unstemmed	Naringin Exhibited Therapeutic Effects against DSS-Induced Mice Ulcerative Colitis in Intestinal Barrier–Dependent Manner
title_sort	naringin exhibited therapeutic effects against dss-induced mice ulcerative colitis in intestinal barrier–dependent manner
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2c829e2ece114bbabac99089205388e1
work_keys_str_mv	AT ruigecao naringinexhibitedtherapeuticeffectsagainstdssinducedmiceulcerativecolitisinintestinalbarrierdependentmanner AT xingwu naringinexhibitedtherapeuticeffectsagainstdssinducedmiceulcerativecolitisinintestinalbarrierdependentmanner AT huiguo naringinexhibitedtherapeuticeffectsagainstdssinducedmiceulcerativecolitisinintestinalbarrierdependentmanner AT xinpan naringinexhibitedtherapeuticeffectsagainstdssinducedmiceulcerativecolitisinintestinalbarrierdependentmanner AT ronghuang naringinexhibitedtherapeuticeffectsagainstdssinducedmiceulcerativecolitisinintestinalbarrierdependentmanner AT gangqiangwang naringinexhibitedtherapeuticeffectsagainstdssinducedmiceulcerativecolitisinintestinalbarrierdependentmanner AT jikailiu naringinexhibitedtherapeuticeffectsagainstdssinducedmiceulcerativecolitisinintestinalbarrierdependentmanner
_version_	1718431752753512448

Naringin Exhibited Therapeutic Effects against DSS-Induced Mice Ulcerative Colitis in Intestinal Barrier–Dependent Manner

Ejemplares similares