Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas

Cutaneous gamma-delta T cell lymphomas are rare but aggressive cancers. Here, by DNA, RNA and T cell receptor sequencing, the authors elucidate the molecular ontogeny by revising the cell of origin and identifying potentially targetable mutations.

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Autores principales:	Jay Daniels, Peter G. Doukas, Maria E. Martinez Escala, Kimberly G. Ringbloom, David J. H. Shih, Jingyi Yang, Kyle Tegtmeyer, Joonhee Park, Jane J. Thomas, Mehmet E. Selli, Can Altunbulakli, Ragul Gowthaman, Samuel H. Mo, Balaji Jothishankar, David R. Pease, Barbara Pro, Farah R. Abdulla, Christopher Shea, Nidhi Sahni, Alejandro A. Gru, Brian G. Pierce, Abner Louissaint, Joan Guitart, Jaehyuk Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c834194658843db9eea5ff1ea5e480a
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spelling	oai:doaj.org-article:2c834194658843db9eea5ff1ea5e480a2021-12-02T14:41:23ZCellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas10.1038/s41467-020-15572-72041-1723https://doaj.org/article/2c834194658843db9eea5ff1ea5e480a2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15572-7https://doaj.org/toc/2041-1723Cutaneous gamma-delta T cell lymphomas are rare but aggressive cancers. Here, by DNA, RNA and T cell receptor sequencing, the authors elucidate the molecular ontogeny by revising the cell of origin and identifying potentially targetable mutations.Jay DanielsPeter G. DoukasMaria E. Martinez EscalaKimberly G. RingbloomDavid J. H. ShihJingyi YangKyle TegtmeyerJoonhee ParkJane J. ThomasMehmet E. SelliCan AltunbulakliRagul GowthamanSamuel H. MoBalaji JothishankarDavid R. PeaseBarbara ProFarah R. AbdullaChristopher SheaNidhi SahniAlejandro A. GruBrian G. PierceAbner LouissaintJoan GuitartJaehyuk ChoiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jay Daniels Peter G. Doukas Maria E. Martinez Escala Kimberly G. Ringbloom David J. H. Shih Jingyi Yang Kyle Tegtmeyer Joonhee Park Jane J. Thomas Mehmet E. Selli Can Altunbulakli Ragul Gowthaman Samuel H. Mo Balaji Jothishankar David R. Pease Barbara Pro Farah R. Abdulla Christopher Shea Nidhi Sahni Alejandro A. Gru Brian G. Pierce Abner Louissaint Joan Guitart Jaehyuk Choi Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas
description	Cutaneous gamma-delta T cell lymphomas are rare but aggressive cancers. Here, by DNA, RNA and T cell receptor sequencing, the authors elucidate the molecular ontogeny by revising the cell of origin and identifying potentially targetable mutations.
format	article
author	Jay Daniels Peter G. Doukas Maria E. Martinez Escala Kimberly G. Ringbloom David J. H. Shih Jingyi Yang Kyle Tegtmeyer Joonhee Park Jane J. Thomas Mehmet E. Selli Can Altunbulakli Ragul Gowthaman Samuel H. Mo Balaji Jothishankar David R. Pease Barbara Pro Farah R. Abdulla Christopher Shea Nidhi Sahni Alejandro A. Gru Brian G. Pierce Abner Louissaint Joan Guitart Jaehyuk Choi
author_facet	Jay Daniels Peter G. Doukas Maria E. Martinez Escala Kimberly G. Ringbloom David J. H. Shih Jingyi Yang Kyle Tegtmeyer Joonhee Park Jane J. Thomas Mehmet E. Selli Can Altunbulakli Ragul Gowthaman Samuel H. Mo Balaji Jothishankar David R. Pease Barbara Pro Farah R. Abdulla Christopher Shea Nidhi Sahni Alejandro A. Gru Brian G. Pierce Abner Louissaint Joan Guitart Jaehyuk Choi
author_sort	Jay Daniels
title	Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas
title_short	Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas
title_full	Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas
title_fullStr	Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas
title_full_unstemmed	Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas
title_sort	cellular origins and genetic landscape of cutaneous gamma delta t cell lymphomas
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2c834194658843db9eea5ff1ea5e480a
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Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas

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