GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways
Systemic sclerosis (SSc) is a heterogeneous chronic autoimmune disease that affects the connective tissue. Here, López-Isac et al. identify 13 new risk loci for SSc as well as loci specific for limited cutaneous and diffuse SSc and, defining credible sets and performing functional annotation, highli...
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Nature Portfolio
2019
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oai:doaj.org-article:2c83b5b19dd94142a96da7824aa29e782021-12-02T17:01:28ZGWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways10.1038/s41467-019-12760-y2041-1723https://doaj.org/article/2c83b5b19dd94142a96da7824aa29e782019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12760-yhttps://doaj.org/toc/2041-1723Systemic sclerosis (SSc) is a heterogeneous chronic autoimmune disease that affects the connective tissue. Here, López-Isac et al. identify 13 new risk loci for SSc as well as loci specific for limited cutaneous and diffuse SSc and, defining credible sets and performing functional annotation, highlight key pathways and cell types for SSc.Elena López-IsacMarialbert Acosta-HerreraMartin KerickShervin AssassiAnsuman T. SatpathyJeffrey GranjaMaxwell R. MumbachLorenzo BerettaCarmen P. SimeónPatricia CarreiraNorberto Ortego-CentenoIvan CastellviLara Bossini-CastilloF. David CarmonaGisela OrozcoNicolas HunzelmannJörg H. W. DistlerAndre FrankeClaudio LunardiGianluca MoronciniArmando GabrielliJeska de Vries-BouwstraCisca WijmengaBobby P. C. KoelemanAnnika NordinLeonid PadyukovAnna-Maria Hoffmann-VoldBenedicte LieEuropean Scleroderma Group†Susanna ProudmanWendy StevensMandana NikpourAustralian Scleroderma Interest Group (ASIG)Timothy VyseAriane L. HerrickJane WorthingtonChristopher P. DentonYannick AllanoreMatthew A. BrownTimothy R. D. J. RadstakeCarmen FonsecaHoward Y. ChangMaureen D. MayesJavier MartinNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Elena López-Isac Marialbert Acosta-Herrera Martin Kerick Shervin Assassi Ansuman T. Satpathy Jeffrey Granja Maxwell R. Mumbach Lorenzo Beretta Carmen P. Simeón Patricia Carreira Norberto Ortego-Centeno Ivan Castellvi Lara Bossini-Castillo F. David Carmona Gisela Orozco Nicolas Hunzelmann Jörg H. W. Distler Andre Franke Claudio Lunardi Gianluca Moroncini Armando Gabrielli Jeska de Vries-Bouwstra Cisca Wijmenga Bobby P. C. Koeleman Annika Nordin Leonid Padyukov Anna-Maria Hoffmann-Vold Benedicte Lie European Scleroderma Group† Susanna Proudman Wendy Stevens Mandana Nikpour Australian Scleroderma Interest Group (ASIG) Timothy Vyse Ariane L. Herrick Jane Worthington Christopher P. Denton Yannick Allanore Matthew A. Brown Timothy R. D. J. Radstake Carmen Fonseca Howard Y. Chang Maureen D. Mayes Javier Martin GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways |
| description |
Systemic sclerosis (SSc) is a heterogeneous chronic autoimmune disease that affects the connective tissue. Here, López-Isac et al. identify 13 new risk loci for SSc as well as loci specific for limited cutaneous and diffuse SSc and, defining credible sets and performing functional annotation, highlight key pathways and cell types for SSc. |
| format |
article |
| author |
Elena López-Isac Marialbert Acosta-Herrera Martin Kerick Shervin Assassi Ansuman T. Satpathy Jeffrey Granja Maxwell R. Mumbach Lorenzo Beretta Carmen P. Simeón Patricia Carreira Norberto Ortego-Centeno Ivan Castellvi Lara Bossini-Castillo F. David Carmona Gisela Orozco Nicolas Hunzelmann Jörg H. W. Distler Andre Franke Claudio Lunardi Gianluca Moroncini Armando Gabrielli Jeska de Vries-Bouwstra Cisca Wijmenga Bobby P. C. Koeleman Annika Nordin Leonid Padyukov Anna-Maria Hoffmann-Vold Benedicte Lie European Scleroderma Group† Susanna Proudman Wendy Stevens Mandana Nikpour Australian Scleroderma Interest Group (ASIG) Timothy Vyse Ariane L. Herrick Jane Worthington Christopher P. Denton Yannick Allanore Matthew A. Brown Timothy R. D. J. Radstake Carmen Fonseca Howard Y. Chang Maureen D. Mayes Javier Martin |
| author_facet |
Elena López-Isac Marialbert Acosta-Herrera Martin Kerick Shervin Assassi Ansuman T. Satpathy Jeffrey Granja Maxwell R. Mumbach Lorenzo Beretta Carmen P. Simeón Patricia Carreira Norberto Ortego-Centeno Ivan Castellvi Lara Bossini-Castillo F. David Carmona Gisela Orozco Nicolas Hunzelmann Jörg H. W. Distler Andre Franke Claudio Lunardi Gianluca Moroncini Armando Gabrielli Jeska de Vries-Bouwstra Cisca Wijmenga Bobby P. C. Koeleman Annika Nordin Leonid Padyukov Anna-Maria Hoffmann-Vold Benedicte Lie European Scleroderma Group† Susanna Proudman Wendy Stevens Mandana Nikpour Australian Scleroderma Interest Group (ASIG) Timothy Vyse Ariane L. Herrick Jane Worthington Christopher P. Denton Yannick Allanore Matthew A. Brown Timothy R. D. J. Radstake Carmen Fonseca Howard Y. Chang Maureen D. Mayes Javier Martin |
| author_sort |
Elena López-Isac |
| title |
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways |
| title_short |
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways |
| title_full |
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways |
| title_fullStr |
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways |
| title_full_unstemmed |
GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways |
| title_sort |
gwas for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/2c83b5b19dd94142a96da7824aa29e78 |
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