Outer membrane and phospholipid composition of the target membrane affect the antimicrobial potential of first- and second-generation lipophosphonoxins

Outer membrane and phospholipid composition of the target membrane affect the antimicrobial potential of first- and second-generation lipophosphonoxins

Abstract Lipophosphonoxins (LPPOs) are small modular synthetic antibacterial compounds that target the cytoplasmic membrane. First-generation LPPOs (LPPO I) exhibit an antimicrobial activity against Gram-positive bacteria; however they do not exhibit any activity against Gram-negatives. Second-gener...

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Autores principales: Klára Látrová, Noemi Havlová, Renata Večeřová, Dominik Pinkas, Kateřina Bogdanová, Milan Kolář, Radovan Fišer, Ivo Konopásek, Duy Dinh Do Pham, Dominik Rejman, Gabriela Mikušová
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/2c8af9111366446e9e22f3b263b30b4d
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