Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis

Abstract The oral microbiome plays an important role in the human microbial community and in maintaining the health of an individual. Imbalances in the oral microbiome may contribute to oral and systemic diseases. The progression of periodontal disease is closely related to the growth of bacteria, s...

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Autores principales:	Tomohiro Miyoshi, Shogo Oge, Satoshi Nakata, Yuji Ueno, Hidehiko Ukita, Reiko Kousaka, Yuki Miura, Nobuo Yoshinari, Akihiro Yoshida
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2c8cc52319674dd19ef56209686f5104
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spelling	oai:doaj.org-article:2c8cc52319674dd19ef56209686f51042021-12-02T15:02:23ZGemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis10.1038/s41598-021-91267-32045-2322https://doaj.org/article/2c8cc52319674dd19ef56209686f51042021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91267-3https://doaj.org/toc/2045-2322Abstract The oral microbiome plays an important role in the human microbial community and in maintaining the health of an individual. Imbalances in the oral microbiome may contribute to oral and systemic diseases. The progression of periodontal disease is closely related to the growth of bacteria, such as Porphyromonas gingivalis, in the oral cavity. However, the pathogen growth mechanism specific to periodontal disease remains unknown. This study aimed to identify bacteria associated with periodontal health by focusing on hemolytic bacteria. Unstimulated saliva samples were collected from ten periodontitis patients and five healthy subjects to detect and identify the presence of hemolytic bacteria. The saliva of healthy subjects contained a higher proportion of G. haemolysans than saliva samples from patients with periodontitis. Growth inhibition assays indicated that the protein components contained in the culture supernatant of G. haemolysans directly suppressed the growth of P. gingivalis. This study shows that the presence of G. haemolysans in saliva is associated with periodontal health and that it inhibits the growth of P. gingivalis in vitro.Tomohiro MiyoshiShogo OgeSatoshi NakataYuji UenoHidehiko UkitaReiko KousakaYuki MiuraNobuo YoshinariAkihiro YoshidaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tomohiro Miyoshi Shogo Oge Satoshi Nakata Yuji Ueno Hidehiko Ukita Reiko Kousaka Yuki Miura Nobuo Yoshinari Akihiro Yoshida Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis
description	Abstract The oral microbiome plays an important role in the human microbial community and in maintaining the health of an individual. Imbalances in the oral microbiome may contribute to oral and systemic diseases. The progression of periodontal disease is closely related to the growth of bacteria, such as Porphyromonas gingivalis, in the oral cavity. However, the pathogen growth mechanism specific to periodontal disease remains unknown. This study aimed to identify bacteria associated with periodontal health by focusing on hemolytic bacteria. Unstimulated saliva samples were collected from ten periodontitis patients and five healthy subjects to detect and identify the presence of hemolytic bacteria. The saliva of healthy subjects contained a higher proportion of G. haemolysans than saliva samples from patients with periodontitis. Growth inhibition assays indicated that the protein components contained in the culture supernatant of G. haemolysans directly suppressed the growth of P. gingivalis. This study shows that the presence of G. haemolysans in saliva is associated with periodontal health and that it inhibits the growth of P. gingivalis in vitro.
format	article
author	Tomohiro Miyoshi Shogo Oge Satoshi Nakata Yuji Ueno Hidehiko Ukita Reiko Kousaka Yuki Miura Nobuo Yoshinari Akihiro Yoshida
author_facet	Tomohiro Miyoshi Shogo Oge Satoshi Nakata Yuji Ueno Hidehiko Ukita Reiko Kousaka Yuki Miura Nobuo Yoshinari Akihiro Yoshida
author_sort	Tomohiro Miyoshi
title	Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis
title_short	Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis
title_full	Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis
title_fullStr	Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis
title_full_unstemmed	Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis
title_sort	gemella haemolysans inhibits the growth of the periodontal pathogen porphyromonas gingivalis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2c8cc52319674dd19ef56209686f5104
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Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis

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