Potential link between genetic polymorphisms of catechol-O-methyltransferase and dopamine receptors and treatment efficacy of risperidone on schizophrenia

Jiyang Han,1 Yan Li,2 Xumei Wang1 1Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China; 2Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, Liaoning, China Objective: The current...

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Autores principales:	Han JY, Li Y, Wang XM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Schizophrenia Catechol-O-methyltransferase Dopamine receptor gene Single nucleotide polymorphisms Risperidone Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2c8f787c627d47189a13b03be4db5f1c
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spelling	oai:doaj.org-article:2c8f787c627d47189a13b03be4db5f1c2021-12-02T05:02:37ZPotential link between genetic polymorphisms of catechol-O-methyltransferase and dopamine receptors and treatment efficacy of risperidone on schizophrenia1178-2021https://doaj.org/article/2c8f787c627d47189a13b03be4db5f1c2017-12-01T00:00:00Zhttps://www.dovepress.com/potential-link-between-genetic-polymorphisms-of-catechol-o-methyltrans-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jiyang Han,1 Yan Li,2 Xumei Wang1 1Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China; 2Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, Liaoning, China Objective: The current study aimed to explore the association of single nucleotide polymorphisms (SNPs) within catechol-O-methyltransferase (COMT) and dopamine receptors with schizophrenia and genetic association with risperidone treatment response.Methods: A total of 690 schizophrenic patients (case group) were selected and 430 healthy people were included as the controls. All patients received risperidone treatment continuously for 8 weeks. Next, peripheral venous blood samples were collected and were subjected to polymerase chain reaction-restriction fragment length polymorphism to amplify and genotype the SNPs within COMT and dopamine receptors. Then, correlation analysis was conducted between Positive and Negative Syndrome Scale improvement rates and SNPs within COMT and the dopamine receptor gene.Results: The allele of DRD1 rs11749676 (A) emerged as a key element in reducing schizophrenia risk with statistical significance (P<0.001). Remarkably, alleles of COMT rs165774 (G), DRD2 rs6277 (T), and DRD3 rs6280 (C) were associated with raised predisposition to schizophrenia (all P<0.001). Regarding DRD1 rs11746641, DRD1 rs11749676, DRD2 rs6277, and DRD3 rs6280, the case group exhibited a lesser frequency of heterozygotes in comparison with wild homozygotes genotype (all P<0.001). SNPs (COMT rs4680, DRD2 rs6275, DRD2 rs1801028, and DRD2 rs6277) were remarkably associated with improvement rates of PANSS total scores (P<0.05). SNPs (COMT rs165599 and DRD2 rs1801028) were significantly associated with risperidone efficacy on negative symptoms (P<0.05).Conclusion: COMT SNPs and dopamine receptor SNPs were correlated with prevalence of schizophrenia and risperidone treatment efficacy of schizophrenia. Keywords: schizophrenia, catechol-O-methyltransferase, dopamine receptor gene, single nucleotide polymorphisms, risperidoneHan JYLi YWang XMDove Medical PressarticleSchizophreniaCatechol-O-methyltransferaseDopamine receptor geneSingle nucleotide polymorphismsRisperidoneNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2935-2943 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Schizophrenia Catechol-O-methyltransferase Dopamine receptor gene Single nucleotide polymorphisms Risperidone Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Schizophrenia Catechol-O-methyltransferase Dopamine receptor gene Single nucleotide polymorphisms Risperidone Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Han JY Li Y Wang XM Potential link between genetic polymorphisms of catechol-O-methyltransferase and dopamine receptors and treatment efficacy of risperidone on schizophrenia
description	Jiyang Han,1 Yan Li,2 Xumei Wang1 1Department of Psychiatry, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China; 2Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health, China Medical University, Shenyang, Liaoning, China Objective: The current study aimed to explore the association of single nucleotide polymorphisms (SNPs) within catechol-O-methyltransferase (COMT) and dopamine receptors with schizophrenia and genetic association with risperidone treatment response.Methods: A total of 690 schizophrenic patients (case group) were selected and 430 healthy people were included as the controls. All patients received risperidone treatment continuously for 8 weeks. Next, peripheral venous blood samples were collected and were subjected to polymerase chain reaction-restriction fragment length polymorphism to amplify and genotype the SNPs within COMT and dopamine receptors. Then, correlation analysis was conducted between Positive and Negative Syndrome Scale improvement rates and SNPs within COMT and the dopamine receptor gene.Results: The allele of DRD1 rs11749676 (A) emerged as a key element in reducing schizophrenia risk with statistical significance (P<0.001). Remarkably, alleles of COMT rs165774 (G), DRD2 rs6277 (T), and DRD3 rs6280 (C) were associated with raised predisposition to schizophrenia (all P<0.001). Regarding DRD1 rs11746641, DRD1 rs11749676, DRD2 rs6277, and DRD3 rs6280, the case group exhibited a lesser frequency of heterozygotes in comparison with wild homozygotes genotype (all P<0.001). SNPs (COMT rs4680, DRD2 rs6275, DRD2 rs1801028, and DRD2 rs6277) were remarkably associated with improvement rates of PANSS total scores (P<0.05). SNPs (COMT rs165599 and DRD2 rs1801028) were significantly associated with risperidone efficacy on negative symptoms (P<0.05).Conclusion: COMT SNPs and dopamine receptor SNPs were correlated with prevalence of schizophrenia and risperidone treatment efficacy of schizophrenia. Keywords: schizophrenia, catechol-O-methyltransferase, dopamine receptor gene, single nucleotide polymorphisms, risperidone
format	article
author	Han JY Li Y Wang XM
author_facet	Han JY Li Y Wang XM
author_sort	Han JY
title	Potential link between genetic polymorphisms of catechol-O-methyltransferase and dopamine receptors and treatment efficacy of risperidone on schizophrenia
title_short	Potential link between genetic polymorphisms of catechol-O-methyltransferase and dopamine receptors and treatment efficacy of risperidone on schizophrenia
title_full	Potential link between genetic polymorphisms of catechol-O-methyltransferase and dopamine receptors and treatment efficacy of risperidone on schizophrenia
title_fullStr	Potential link between genetic polymorphisms of catechol-O-methyltransferase and dopamine receptors and treatment efficacy of risperidone on schizophrenia
title_full_unstemmed	Potential link between genetic polymorphisms of catechol-O-methyltransferase and dopamine receptors and treatment efficacy of risperidone on schizophrenia
title_sort	potential link between genetic polymorphisms of catechol-o-methyltransferase and dopamine receptors and treatment efficacy of risperidone on schizophrenia
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/2c8f787c627d47189a13b03be4db5f1c
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_version_	1718400699512913920

Potential link between genetic polymorphisms of catechol-O-methyltransferase and dopamine receptors and treatment efficacy of risperidone on schizophrenia

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