DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis

DEK is a secreted protein abundant in the synovia of patients with juvenile idiopathic arthritis. Here the authors show DEK is important for neutrophil extracellular trap formation and joint inflammation, and demonstrate therapeutic efficacy of DEK-targeting aptamers in a mouse model of arthritis.

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Autores principales:	Nirit Mor-Vaknin, Anjan Saha, Maureen Legendre, Carmelo Carmona-Rivera, M Asif Amin, Bradley J. Rabquer, Marta J. Gonzales-Hernandez, Julie Jorns, Smriti Mohan, Srilakshmi Yalavarthi, Dave A. Pai, Kristine Angevine, Shelley J. Almburg, Jason S. Knight, Barbara S. Adams, Alisa E. Koch, David A. Fox, David R. Engelke, Mariana J. Kaplan, David M. Markovitz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2c912d0db4e646ad89d036163808223e
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spelling	oai:doaj.org-article:2c912d0db4e646ad89d036163808223e2021-12-02T14:40:35ZDEK-targeting DNA aptamers as therapeutics for inflammatory arthritis10.1038/ncomms142522041-1723https://doaj.org/article/2c912d0db4e646ad89d036163808223e2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14252https://doaj.org/toc/2041-1723DEK is a secreted protein abundant in the synovia of patients with juvenile idiopathic arthritis. Here the authors show DEK is important for neutrophil extracellular trap formation and joint inflammation, and demonstrate therapeutic efficacy of DEK-targeting aptamers in a mouse model of arthritis.Nirit Mor-VakninAnjan SahaMaureen LegendreCarmelo Carmona-RiveraM Asif AminBradley J. RabquerMarta J. Gonzales-HernandezJulie JornsSmriti MohanSrilakshmi YalavarthiDave A. PaiKristine AngevineShelley J. AlmburgJason S. KnightBarbara S. AdamsAlisa E. KochDavid A. FoxDavid R. EngelkeMariana J. KaplanDavid M. MarkovitzNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nirit Mor-Vaknin Anjan Saha Maureen Legendre Carmelo Carmona-Rivera M Asif Amin Bradley J. Rabquer Marta J. Gonzales-Hernandez Julie Jorns Smriti Mohan Srilakshmi Yalavarthi Dave A. Pai Kristine Angevine Shelley J. Almburg Jason S. Knight Barbara S. Adams Alisa E. Koch David A. Fox David R. Engelke Mariana J. Kaplan David M. Markovitz DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis
description	DEK is a secreted protein abundant in the synovia of patients with juvenile idiopathic arthritis. Here the authors show DEK is important for neutrophil extracellular trap formation and joint inflammation, and demonstrate therapeutic efficacy of DEK-targeting aptamers in a mouse model of arthritis.
format	article
author	Nirit Mor-Vaknin Anjan Saha Maureen Legendre Carmelo Carmona-Rivera M Asif Amin Bradley J. Rabquer Marta J. Gonzales-Hernandez Julie Jorns Smriti Mohan Srilakshmi Yalavarthi Dave A. Pai Kristine Angevine Shelley J. Almburg Jason S. Knight Barbara S. Adams Alisa E. Koch David A. Fox David R. Engelke Mariana J. Kaplan David M. Markovitz
author_facet	Nirit Mor-Vaknin Anjan Saha Maureen Legendre Carmelo Carmona-Rivera M Asif Amin Bradley J. Rabquer Marta J. Gonzales-Hernandez Julie Jorns Smriti Mohan Srilakshmi Yalavarthi Dave A. Pai Kristine Angevine Shelley J. Almburg Jason S. Knight Barbara S. Adams Alisa E. Koch David A. Fox David R. Engelke Mariana J. Kaplan David M. Markovitz
author_sort	Nirit Mor-Vaknin
title	DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis
title_short	DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis
title_full	DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis
title_fullStr	DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis
title_full_unstemmed	DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis
title_sort	dek-targeting dna aptamers as therapeutics for inflammatory arthritis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/2c912d0db4e646ad89d036163808223e
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DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis

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