Serotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception.

<h4>Background</h4>Serotonin (5-HT) is highly involved in pain regulation and serotonin-1A (5-HT1A) receptors are important in determining central 5-HT tone. Accordingly, variation in the 5-HT1A receptor gene (HTR1A) may contribute to inter-individual differences in human pain sensitivit...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Fredrik Lindstedt, Bianka Karshikoff, Martin Schalling, Caroline Olgart Höglund, Martin Ingvar, Mats Lekander, Eva Kosek
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2c93a44f41df42ae84ff1cc03a2c30bc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2c93a44f41df42ae84ff1cc03a2c30bc
record_format	dspace
spelling	oai:doaj.org-article:2c93a44f41df42ae84ff1cc03a2c30bc2021-11-18T07:06:56ZSerotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception.1932-620310.1371/journal.pone.0043221https://doaj.org/article/2c93a44f41df42ae84ff1cc03a2c30bc2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22952650/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Serotonin (5-HT) is highly involved in pain regulation and serotonin-1A (5-HT1A) receptors are important in determining central 5-HT tone. Accordingly, variation in the 5-HT1A receptor gene (HTR1A) may contribute to inter-individual differences in human pain sensitivity. The minor G-allele of the HTR1A single nucleotide polymorphism (SNP) rs6295 attenuates firing of serotonergic neurons and reduces postsynaptic expression of the receptor. Experiments in rodents suggest that 5-HT1A-agonism modulates pain in opposite directions at mild compared to high noxious intensities. Based upon this and several other similar observations, we hypothesized that G-carriers would exhibit a relative hypoalgesia at mild thermal stimuli but tend towards hyperalgesia at higher noxious intensities.<h4>Methods</h4>Fourty-nine healthy individuals were selectively genotyped for rs6295. Heat- and cold-pain thresholds were assessed along with VAS-ratings of a range of suprathreshold noxious heat intensities (45°C-49°C). Nociceptive-flexion reflex (NFR) thresholds were also assessed.<h4>Results</h4>Volunteers did not deviate significantly from Hardy-Weinberg equilibrium. G-carriers were less sensitive to threshold-level thermal pain. This relative hypoalgesia was abolished at suprathreshold noxious intensities where G-carriers instead increased their ratings of heat-pain significantly more than C-homozygotes. No differences with regard to NFR-thresholds emerged.<h4>Conclusion/significance</h4>To the best of our knowledge this is the first study of human pain perception on the basis of variation in HTR1A. The results illustrate the importance of including a range of stimulus intensities in assessments of pain sensitivity. In speculation, we propose that an attenuated serotonergic tone may be related to a 'hypo- to hyperalgesic' response-pattern. The involved mechanisms could be of clinical interest as variation in pain regulation is known to influence the risk of developing pain pathologies. Further investigations are therefore warranted.Fredrik LindstedtBianka KarshikoffMartin SchallingCaroline Olgart HöglundMartin IngvarMats LekanderEva KosekPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 8, p e43221 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fredrik Lindstedt Bianka Karshikoff Martin Schalling Caroline Olgart Höglund Martin Ingvar Mats Lekander Eva Kosek Serotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception.
description	<h4>Background</h4>Serotonin (5-HT) is highly involved in pain regulation and serotonin-1A (5-HT1A) receptors are important in determining central 5-HT tone. Accordingly, variation in the 5-HT1A receptor gene (HTR1A) may contribute to inter-individual differences in human pain sensitivity. The minor G-allele of the HTR1A single nucleotide polymorphism (SNP) rs6295 attenuates firing of serotonergic neurons and reduces postsynaptic expression of the receptor. Experiments in rodents suggest that 5-HT1A-agonism modulates pain in opposite directions at mild compared to high noxious intensities. Based upon this and several other similar observations, we hypothesized that G-carriers would exhibit a relative hypoalgesia at mild thermal stimuli but tend towards hyperalgesia at higher noxious intensities.<h4>Methods</h4>Fourty-nine healthy individuals were selectively genotyped for rs6295. Heat- and cold-pain thresholds were assessed along with VAS-ratings of a range of suprathreshold noxious heat intensities (45°C-49°C). Nociceptive-flexion reflex (NFR) thresholds were also assessed.<h4>Results</h4>Volunteers did not deviate significantly from Hardy-Weinberg equilibrium. G-carriers were less sensitive to threshold-level thermal pain. This relative hypoalgesia was abolished at suprathreshold noxious intensities where G-carriers instead increased their ratings of heat-pain significantly more than C-homozygotes. No differences with regard to NFR-thresholds emerged.<h4>Conclusion/significance</h4>To the best of our knowledge this is the first study of human pain perception on the basis of variation in HTR1A. The results illustrate the importance of including a range of stimulus intensities in assessments of pain sensitivity. In speculation, we propose that an attenuated serotonergic tone may be related to a 'hypo- to hyperalgesic' response-pattern. The involved mechanisms could be of clinical interest as variation in pain regulation is known to influence the risk of developing pain pathologies. Further investigations are therefore warranted.
format	article
author	Fredrik Lindstedt Bianka Karshikoff Martin Schalling Caroline Olgart Höglund Martin Ingvar Mats Lekander Eva Kosek
author_facet	Fredrik Lindstedt Bianka Karshikoff Martin Schalling Caroline Olgart Höglund Martin Ingvar Mats Lekander Eva Kosek
author_sort	Fredrik Lindstedt
title	Serotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception.
title_short	Serotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception.
title_full	Serotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception.
title_fullStr	Serotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception.
title_full_unstemmed	Serotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception.
title_sort	serotonin-1a receptor polymorphism (rs6295) associated with thermal pain perception.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/2c93a44f41df42ae84ff1cc03a2c30bc
work_keys_str_mv	AT fredriklindstedt serotonin1areceptorpolymorphismrs6295associatedwiththermalpainperception AT biankakarshikoff serotonin1areceptorpolymorphismrs6295associatedwiththermalpainperception AT martinschalling serotonin1areceptorpolymorphismrs6295associatedwiththermalpainperception AT carolineolgarthoglund serotonin1areceptorpolymorphismrs6295associatedwiththermalpainperception AT martiningvar serotonin1areceptorpolymorphismrs6295associatedwiththermalpainperception AT matslekander serotonin1areceptorpolymorphismrs6295associatedwiththermalpainperception AT evakosek serotonin1areceptorpolymorphismrs6295associatedwiththermalpainperception
_version_	1718423906324316160

Serotonin-1A receptor polymorphism (rs6295) associated with thermal pain perception.

Ejemplares similares