Analysis of somatic mutations across the kinome reveals loss-of-function mutations in multiple cancer types
Abstract In this study we use somatic cancer mutations to identify important functional residues within sets of related genes. We focus on protein kinases, a superfamily of phosphotransferases that share homologous sequences and structural motifs and have many connections to cancer. We develop sever...
Enregistré dans:
| Auteurs principaux: | , |
|---|---|
| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2017
|
| Sujets: | |
| Accès en ligne: | https://doaj.org/article/2c968a60686444bfb6cc99fa031b2e91 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|