Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation
Invadosomes degrade extracellular matrix and facilitate cell invasion but their molecular composition is not fully understood. Here, the authors combine laser capture and mass spectrometry to map the proteome of invadosomes, showing that they rely on internal translational activity to maintain their...
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Nature Portfolio
2018
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oai:doaj.org-article:2c995818d6d044ceb85f3e411b0ea6e82021-12-02T14:38:47ZCombining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation10.1038/s41467-018-04461-92041-1723https://doaj.org/article/2c995818d6d044ceb85f3e411b0ea6e82018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04461-9https://doaj.org/toc/2041-1723Invadosomes degrade extracellular matrix and facilitate cell invasion but their molecular composition is not fully understood. Here, the authors combine laser capture and mass spectrometry to map the proteome of invadosomes, showing that they rely on internal translational activity to maintain their structure.Zakaria EzzoukhryElodie HenrietFabrice P. CordelièresJean-William DupuyMarlène MaîtreNathan GaySylvaine Di-TommasoLuc MercierJacky G. GoetzMarion PeterFrédéric BardViolaine MoreauAnne-Aurélie RaymondFrédéric SaltelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018) |
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DOAJ |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Zakaria Ezzoukhry Elodie Henriet Fabrice P. Cordelières Jean-William Dupuy Marlène Maître Nathan Gay Sylvaine Di-Tommaso Luc Mercier Jacky G. Goetz Marion Peter Frédéric Bard Violaine Moreau Anne-Aurélie Raymond Frédéric Saltel Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation |
| description |
Invadosomes degrade extracellular matrix and facilitate cell invasion but their molecular composition is not fully understood. Here, the authors combine laser capture and mass spectrometry to map the proteome of invadosomes, showing that they rely on internal translational activity to maintain their structure. |
| format |
article |
| author |
Zakaria Ezzoukhry Elodie Henriet Fabrice P. Cordelières Jean-William Dupuy Marlène Maître Nathan Gay Sylvaine Di-Tommaso Luc Mercier Jacky G. Goetz Marion Peter Frédéric Bard Violaine Moreau Anne-Aurélie Raymond Frédéric Saltel |
| author_facet |
Zakaria Ezzoukhry Elodie Henriet Fabrice P. Cordelières Jean-William Dupuy Marlène Maître Nathan Gay Sylvaine Di-Tommaso Luc Mercier Jacky G. Goetz Marion Peter Frédéric Bard Violaine Moreau Anne-Aurélie Raymond Frédéric Saltel |
| author_sort |
Zakaria Ezzoukhry |
| title |
Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation |
| title_short |
Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation |
| title_full |
Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation |
| title_fullStr |
Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation |
| title_full_unstemmed |
Combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation |
| title_sort |
combining laser capture microdissection and proteomics reveals an active translation machinery controlling invadosome formation |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/2c995818d6d044ceb85f3e411b0ea6e8 |
| work_keys_str_mv |
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| _version_ |
1718390822130417664 |