Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Here, the authors use 1H-MRS methodology to show hepatic SFA fraction is a measure of DNL and specifically may hamper hepatic insulin...

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Autores principales: Kay H. M. Roumans, Lucas Lindeboom, Pandichelvam Veeraiah, Carlijn M. E. Remie, Esther Phielix, Bas Havekes, Yvonne M. H. Bruls, Martijn C. G. J. Brouwers, Marcus Ståhlman, Marjan Alssema, Harry P. F. Peters, Renée de Mutsert, Bart Staels, Marja-Riitta Taskinen, Jan Borén, Patrick Schrauwen, Vera B. Schrauwen-Hinderling
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/2c9a2f8b1cf44a76b5b73a890bc8f73e
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spelling oai:doaj.org-article:2c9a2f8b1cf44a76b5b73a890bc8f73e2021-12-02T15:33:31ZHepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance10.1038/s41467-020-15684-02041-1723https://doaj.org/article/2c9a2f8b1cf44a76b5b73a890bc8f73e2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15684-0https://doaj.org/toc/2041-1723Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Here, the authors use 1H-MRS methodology to show hepatic SFA fraction is a measure of DNL and specifically may hamper hepatic insulin sensitivity.Kay H. M. RoumansLucas LindeboomPandichelvam VeeraiahCarlijn M. E. RemieEsther PhielixBas HavekesYvonne M. H. BrulsMartijn C. G. J. BrouwersMarcus StåhlmanMarjan AlssemaHarry P. F. PetersRenée de MutsertBart StaelsMarja-Riitta TaskinenJan BorénPatrick SchrauwenVera B. Schrauwen-HinderlingNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kay H. M. Roumans
Lucas Lindeboom
Pandichelvam Veeraiah
Carlijn M. E. Remie
Esther Phielix
Bas Havekes
Yvonne M. H. Bruls
Martijn C. G. J. Brouwers
Marcus Ståhlman
Marjan Alssema
Harry P. F. Peters
Renée de Mutsert
Bart Staels
Marja-Riitta Taskinen
Jan Borén
Patrick Schrauwen
Vera B. Schrauwen-Hinderling
Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
description Hepatic steatosis is associated with poor cardiometabolic health, with de novo lipogenesis (DNL) contributing to hepatic steatosis and subsequent insulin resistance. Here, the authors use 1H-MRS methodology to show hepatic SFA fraction is a measure of DNL and specifically may hamper hepatic insulin sensitivity.
format article
author Kay H. M. Roumans
Lucas Lindeboom
Pandichelvam Veeraiah
Carlijn M. E. Remie
Esther Phielix
Bas Havekes
Yvonne M. H. Bruls
Martijn C. G. J. Brouwers
Marcus Ståhlman
Marjan Alssema
Harry P. F. Peters
Renée de Mutsert
Bart Staels
Marja-Riitta Taskinen
Jan Borén
Patrick Schrauwen
Vera B. Schrauwen-Hinderling
author_facet Kay H. M. Roumans
Lucas Lindeboom
Pandichelvam Veeraiah
Carlijn M. E. Remie
Esther Phielix
Bas Havekes
Yvonne M. H. Bruls
Martijn C. G. J. Brouwers
Marcus Ståhlman
Marjan Alssema
Harry P. F. Peters
Renée de Mutsert
Bart Staels
Marja-Riitta Taskinen
Jan Borén
Patrick Schrauwen
Vera B. Schrauwen-Hinderling
author_sort Kay H. M. Roumans
title Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
title_short Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
title_full Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
title_fullStr Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
title_full_unstemmed Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
title_sort hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/2c9a2f8b1cf44a76b5b73a890bc8f73e
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