Effectiveness of the Korean National Cancer Screening Program in reducing breast cancer mortality

Abstract High incidences of breast cancer (BC) are reported in Asian women in their forties, and it is not clear whether mammographic screening reduces mortality among them. This study evaluated the effect of BC screening on mortality in Korea. We conducted a nationwide prospective cohort study of w...

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Autores principales:	Eunji Choi, Jae Kwan Jun, Mina Suh, Kyu-Won Jung, Boyoung Park, Kyeongmin Lee, So-Youn Jung, Eun Sook Lee, Kui Son Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/2ca2b09e57f94b25baf311088af9baef
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spelling	oai:doaj.org-article:2ca2b09e57f94b25baf311088af9baef2021-12-02T18:18:52ZEffectiveness of the Korean National Cancer Screening Program in reducing breast cancer mortality10.1038/s41523-021-00295-92374-4677https://doaj.org/article/2ca2b09e57f94b25baf311088af9baef2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41523-021-00295-9https://doaj.org/toc/2374-4677Abstract High incidences of breast cancer (BC) are reported in Asian women in their forties, and it is not clear whether mammographic screening reduces mortality among them. This study evaluated the effect of BC screening on mortality in Korea. We conducted a nationwide prospective cohort study of women invited to the Korean National Cancer Screening Program (KNCSP) between 2002 and 2003 (N = 8,300,682), with data linkage to the Korea Central Cancer Registry and death certificates through 2014 and 2015, respectively. Exposure to mammographic screening was defined using a modified never/ever approach. The primary study outcome was adjusted mortality rate ratio (MRR) for BC among screened and non-screened women estimated by Poisson regression. An adjusted MRR for all cause-death other than BC was examined to account for selection bias in the cohort. BC incidence rates for screened and non-screened women were 84.41 and 82.88 per 100,000 women-years, respectively. BC mortality rates for screened and non-screened women were 5.81 and 13.43 per 100,000 women-years, respectively, with an adjusted MRR for BC of 0.43 (95% CI, 0.41−0.44). The adjusted MRR for all-cause death excluding BC was 0.52 (95% CI, 0.52−0.52). The greatest reduction in BC mortality was noted for women aged 45−54 years, and there was no observable reduction in mortality after the age of 70 years. In conclusion, the KNCSP has been effective in reducing BC mortality among Korean women aged 40−69 years.Eunji ChoiJae Kwan JunMina SuhKyu-Won JungBoyoung ParkKyeongmin LeeSo-Youn JungEun Sook LeeKui Son ChoiNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 7, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Eunji Choi Jae Kwan Jun Mina Suh Kyu-Won Jung Boyoung Park Kyeongmin Lee So-Youn Jung Eun Sook Lee Kui Son Choi Effectiveness of the Korean National Cancer Screening Program in reducing breast cancer mortality
description	Abstract High incidences of breast cancer (BC) are reported in Asian women in their forties, and it is not clear whether mammographic screening reduces mortality among them. This study evaluated the effect of BC screening on mortality in Korea. We conducted a nationwide prospective cohort study of women invited to the Korean National Cancer Screening Program (KNCSP) between 2002 and 2003 (N = 8,300,682), with data linkage to the Korea Central Cancer Registry and death certificates through 2014 and 2015, respectively. Exposure to mammographic screening was defined using a modified never/ever approach. The primary study outcome was adjusted mortality rate ratio (MRR) for BC among screened and non-screened women estimated by Poisson regression. An adjusted MRR for all cause-death other than BC was examined to account for selection bias in the cohort. BC incidence rates for screened and non-screened women were 84.41 and 82.88 per 100,000 women-years, respectively. BC mortality rates for screened and non-screened women were 5.81 and 13.43 per 100,000 women-years, respectively, with an adjusted MRR for BC of 0.43 (95% CI, 0.41−0.44). The adjusted MRR for all-cause death excluding BC was 0.52 (95% CI, 0.52−0.52). The greatest reduction in BC mortality was noted for women aged 45−54 years, and there was no observable reduction in mortality after the age of 70 years. In conclusion, the KNCSP has been effective in reducing BC mortality among Korean women aged 40−69 years.
format	article
author	Eunji Choi Jae Kwan Jun Mina Suh Kyu-Won Jung Boyoung Park Kyeongmin Lee So-Youn Jung Eun Sook Lee Kui Son Choi
author_facet	Eunji Choi Jae Kwan Jun Mina Suh Kyu-Won Jung Boyoung Park Kyeongmin Lee So-Youn Jung Eun Sook Lee Kui Son Choi
author_sort	Eunji Choi
title	Effectiveness of the Korean National Cancer Screening Program in reducing breast cancer mortality
title_short	Effectiveness of the Korean National Cancer Screening Program in reducing breast cancer mortality
title_full	Effectiveness of the Korean National Cancer Screening Program in reducing breast cancer mortality
title_fullStr	Effectiveness of the Korean National Cancer Screening Program in reducing breast cancer mortality
title_full_unstemmed	Effectiveness of the Korean National Cancer Screening Program in reducing breast cancer mortality
title_sort	effectiveness of the korean national cancer screening program in reducing breast cancer mortality
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2ca2b09e57f94b25baf311088af9baef
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Effectiveness of the Korean National Cancer Screening Program in reducing breast cancer mortality

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