Potential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity

Abstract Background We investigated the radiodensity of epicardial (EAT), subcutaneous (SAT), and visceral adipose tissue (VAT) before and after treatment with anthracyclines in a population of breast cancer (BC) patients, and in controls not treated with anthracyclines, to detect a potential role o...

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Autores principales:	Caterina Beatrice Monti, Simone Schiaffino, Maria Del Mar Galimberti Ortiz, Davide Capra, Moreno Zanardo, Elena De Benedictis, Alberto Gianluigi Luporini, Pietro Spagnolo, Francesco Secchi, Francesco Sardanelli
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	Anthracyclines Cardiotoxicity Breast neoplasms Biomarkers Tomography, X-ray computed Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/2ca2caf490e54e20b6e7a1b6ae8ada30
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spelling	oai:doaj.org-article:2ca2caf490e54e20b6e7a1b6ae8ada302021-11-07T12:14:35ZPotential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity10.1186/s13244-021-01069-41869-4101https://doaj.org/article/2ca2caf490e54e20b6e7a1b6ae8ada302021-11-01T00:00:00Zhttps://doi.org/10.1186/s13244-021-01069-4https://doaj.org/toc/1869-4101Abstract Background We investigated the radiodensity of epicardial (EAT), subcutaneous (SAT), and visceral adipose tissue (VAT) before and after treatment with anthracyclines in a population of breast cancer (BC) patients, and in controls not treated with anthracyclines, to detect a potential role of EAT density as a biomarker of changes related to chemotherapy cardiotoxicity. Methods We reviewed BC patients treated with anthracyclines who underwent CT before (CT-t0) and after (CT-t1) chemotherapy, and age- and sex-matched controls who underwent two CT examinations at comparable intervals. On non-contrast scans, EAT was segmented contouring the pericardium and thresholding between -190 and -30 Hounsfield units (HU), and SAT and VAT were segmented with two 15-mm diameter regions of interest thresholded between -195 and -45 HU. Results Thirty-two female patients and 32 controls were included. There were no differences in age (p = 0.439) and follow-up duration (p = 0.162) between patients and controls. Between CT-t0 and CT-t1, EAT density decreased in BC patients (-66 HU, interquartile range [IQR] -71 to -63 HU, to -71 HU, IQR -75 to -66 HU, p = 0.003), while it did not vary in controls (p = 0.955). SAT density increased from CT-t0 to CT-t1 in BC patients (-107 HU, IQR -111 to -105 HU, to -105 HU, IQR -110 to -100 HU, p = 0.014), whereas it did not change in controls (p = 0.477). VAT density did not vary in either BC patients (p = 0.911) or controls (p = 0.627). Conclusions EAT density appears to be influenced by anthracycline treatment for BC, well known for its cardiotoxicity, shifting towards lower values indicative of a less active metabolism.Caterina Beatrice MontiSimone SchiaffinoMaria Del Mar Galimberti OrtizDavide CapraMoreno ZanardoElena De BenedictisAlberto Gianluigi LuporiniPietro SpagnoloFrancesco SecchiFrancesco SardanelliSpringerOpenarticleAnthracyclinesCardiotoxicityBreast neoplasmsBiomarkersTomography, X-ray computedMedical physics. Medical radiology. Nuclear medicineR895-920ENInsights into Imaging, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Anthracyclines Cardiotoxicity Breast neoplasms Biomarkers Tomography, X-ray computed Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	Anthracyclines Cardiotoxicity Breast neoplasms Biomarkers Tomography, X-ray computed Medical physics. Medical radiology. Nuclear medicine R895-920 Caterina Beatrice Monti Simone Schiaffino Maria Del Mar Galimberti Ortiz Davide Capra Moreno Zanardo Elena De Benedictis Alberto Gianluigi Luporini Pietro Spagnolo Francesco Secchi Francesco Sardanelli Potential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity
description	Abstract Background We investigated the radiodensity of epicardial (EAT), subcutaneous (SAT), and visceral adipose tissue (VAT) before and after treatment with anthracyclines in a population of breast cancer (BC) patients, and in controls not treated with anthracyclines, to detect a potential role of EAT density as a biomarker of changes related to chemotherapy cardiotoxicity. Methods We reviewed BC patients treated with anthracyclines who underwent CT before (CT-t0) and after (CT-t1) chemotherapy, and age- and sex-matched controls who underwent two CT examinations at comparable intervals. On non-contrast scans, EAT was segmented contouring the pericardium and thresholding between -190 and -30 Hounsfield units (HU), and SAT and VAT were segmented with two 15-mm diameter regions of interest thresholded between -195 and -45 HU. Results Thirty-two female patients and 32 controls were included. There were no differences in age (p = 0.439) and follow-up duration (p = 0.162) between patients and controls. Between CT-t0 and CT-t1, EAT density decreased in BC patients (-66 HU, interquartile range [IQR] -71 to -63 HU, to -71 HU, IQR -75 to -66 HU, p = 0.003), while it did not vary in controls (p = 0.955). SAT density increased from CT-t0 to CT-t1 in BC patients (-107 HU, IQR -111 to -105 HU, to -105 HU, IQR -110 to -100 HU, p = 0.014), whereas it did not change in controls (p = 0.477). VAT density did not vary in either BC patients (p = 0.911) or controls (p = 0.627). Conclusions EAT density appears to be influenced by anthracycline treatment for BC, well known for its cardiotoxicity, shifting towards lower values indicative of a less active metabolism.
format	article
author	Caterina Beatrice Monti Simone Schiaffino Maria Del Mar Galimberti Ortiz Davide Capra Moreno Zanardo Elena De Benedictis Alberto Gianluigi Luporini Pietro Spagnolo Francesco Secchi Francesco Sardanelli
author_facet	Caterina Beatrice Monti Simone Schiaffino Maria Del Mar Galimberti Ortiz Davide Capra Moreno Zanardo Elena De Benedictis Alberto Gianluigi Luporini Pietro Spagnolo Francesco Secchi Francesco Sardanelli
author_sort	Caterina Beatrice Monti
title	Potential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity
title_short	Potential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity
title_full	Potential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity
title_fullStr	Potential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity
title_full_unstemmed	Potential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity
title_sort	potential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/2ca2caf490e54e20b6e7a1b6ae8ada30
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Potential role of epicardial adipose tissue as a biomarker of anthracycline cardiotoxicity

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