Complex comprised of dextran magnetite and conjugated cisplatin exhibiting selective hyperthermic and controlled-release potential

Akinaga Sonoda1, Norihisa Nitta1, Ayumi Nitta-Seko1, Shinich Ohta1, Shigeyuki Takamatsu2, Yoshio Ikehata3, Isamu Nagano3, Jun-ichiro Jo4, Yasuhiko Tabata4, Masashi Takahashi1, Osamu Matsui3, Kiyoshi Murata11Department of Radiology, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga,...

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Autores principales:	Akinaga Sonoda, Norihisa Nitta, Ayumi Nitta-Seko, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2ca42ac44bf74ad49cb162fccbc0b83c
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spelling	oai:doaj.org-article:2ca42ac44bf74ad49cb162fccbc0b83c2021-12-02T03:11:37ZComplex comprised of dextran magnetite and conjugated cisplatin exhibiting selective hyperthermic and controlled-release potential1176-91141178-2013https://doaj.org/article/2ca42ac44bf74ad49cb162fccbc0b83c2010-07-01T00:00:00Zhttp://www.dovepress.com/complex-comprised-of-dextran-magnetite-and-conjugated-cisplatin-exhibi-a4837https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Akinaga Sonoda1, Norihisa Nitta1, Ayumi Nitta-Seko1, Shinich Ohta1, Shigeyuki Takamatsu2, Yoshio Ikehata3, Isamu Nagano3, Jun-ichiro Jo4, Yasuhiko Tabata4, Masashi Takahashi1, Osamu Matsui3, Kiyoshi Murata11Department of Radiology, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga, 520-2192, Japan; 2Department of Radiology, Graduate School of Medical Science, Kanazawa University, Takara-machi 13-1, Kanazawa Ishikawa, 920-8641, Japan; 3Department of Natural Science and Technology, Graduate School of Engineering, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan; 4Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Shogoin kawara-machi 53, Sakyo-ku 606-8507, Kyoto, JapanAbstract: We developed a dextran-magnetite conjugated cisplatin (DM-Cis) complex for use in thermal ablation and as a chemotherapeutic drug. To produce DM-Cis we reacted Cis with 1 mL DM (56 mg/mL iron). The temperature rise of DM-Cis was measured in vitro and in vivo under a portable induction-heating (IH) device. Platinum desorption from DM-Cis over 24 hours was measured in bovine serum. In in vivo accumulation and magnet and exothermic experiments we used four rat groups. In group 1 we delivered DM-Cis intraperitoneally (ip) and placed magnets subcutaneously (sc). In group 2 we injected saline (ip) and placed magnets (sc). In group 3 we injected DM-Cis (ip) and placed a sc incision (sham). The control (group 4) received an ip injection of saline. Rectus abdominis muscle tissue was stained with hematoxylin-eosin and iron-stained tissue areas (&micro;m2) were calculated. The maximum platinum concentration in DM-Cis was approximately 105.6 &micro;g/mL. Over 24 hours, 33.48% of platinum from DM-Cis was released. There was a significant difference (P &lt; 0.05) in the iron-stained area between group 1 and the other groups. The temperature in muscle tissue registered a maximum of 56&deg;C after about 4 min. DM-Cis may represent a magnetically-accumulated anticancer drug with hyperthermic effects.Keywords: magnetic nanoparticle-conjugated anticancer agents, DM, portable induction &shy;heating device, carboxyl group, rat Akinaga SonodaNorihisa NittaAyumi Nitta-Sekoet alDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 499-504 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Akinaga Sonoda Norihisa Nitta Ayumi Nitta-Seko et al Complex comprised of dextran magnetite and conjugated cisplatin exhibiting selective hyperthermic and controlled-release potential
description	Akinaga Sonoda1, Norihisa Nitta1, Ayumi Nitta-Seko1, Shinich Ohta1, Shigeyuki Takamatsu2, Yoshio Ikehata3, Isamu Nagano3, Jun-ichiro Jo4, Yasuhiko Tabata4, Masashi Takahashi1, Osamu Matsui3, Kiyoshi Murata11Department of Radiology, Shiga University of Medical Science, Setatsukinowa-cho, Otsu, Shiga, 520-2192, Japan; 2Department of Radiology, Graduate School of Medical Science, Kanazawa University, Takara-machi 13-1, Kanazawa Ishikawa, 920-8641, Japan; 3Department of Natural Science and Technology, Graduate School of Engineering, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan; 4Department of Biomaterials, Institute for Frontier Medical Sciences, Kyoto University, Shogoin kawara-machi 53, Sakyo-ku 606-8507, Kyoto, JapanAbstract: We developed a dextran-magnetite conjugated cisplatin (DM-Cis) complex for use in thermal ablation and as a chemotherapeutic drug. To produce DM-Cis we reacted Cis with 1 mL DM (56 mg/mL iron). The temperature rise of DM-Cis was measured in vitro and in vivo under a portable induction-heating (IH) device. Platinum desorption from DM-Cis over 24 hours was measured in bovine serum. In in vivo accumulation and magnet and exothermic experiments we used four rat groups. In group 1 we delivered DM-Cis intraperitoneally (ip) and placed magnets subcutaneously (sc). In group 2 we injected saline (ip) and placed magnets (sc). In group 3 we injected DM-Cis (ip) and placed a sc incision (sham). The control (group 4) received an ip injection of saline. Rectus abdominis muscle tissue was stained with hematoxylin-eosin and iron-stained tissue areas (&micro;m2) were calculated. The maximum platinum concentration in DM-Cis was approximately 105.6 &micro;g/mL. Over 24 hours, 33.48% of platinum from DM-Cis was released. There was a significant difference (P &lt; 0.05) in the iron-stained area between group 1 and the other groups. The temperature in muscle tissue registered a maximum of 56&deg;C after about 4 min. DM-Cis may represent a magnetically-accumulated anticancer drug with hyperthermic effects.Keywords: magnetic nanoparticle-conjugated anticancer agents, DM, portable induction &shy;heating device, carboxyl group, rat
format	article
author	Akinaga Sonoda Norihisa Nitta Ayumi Nitta-Seko et al
author_facet	Akinaga Sonoda Norihisa Nitta Ayumi Nitta-Seko et al
author_sort	Akinaga Sonoda
title	Complex comprised of dextran magnetite and conjugated cisplatin exhibiting selective hyperthermic and controlled-release potential
title_short	Complex comprised of dextran magnetite and conjugated cisplatin exhibiting selective hyperthermic and controlled-release potential
title_full	Complex comprised of dextran magnetite and conjugated cisplatin exhibiting selective hyperthermic and controlled-release potential
title_fullStr	Complex comprised of dextran magnetite and conjugated cisplatin exhibiting selective hyperthermic and controlled-release potential
title_full_unstemmed	Complex comprised of dextran magnetite and conjugated cisplatin exhibiting selective hyperthermic and controlled-release potential
title_sort	complex comprised of dextran magnetite and conjugated cisplatin exhibiting selective hyperthermic and controlled-release potential
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/2ca42ac44bf74ad49cb162fccbc0b83c
work_keys_str_mv	AT akinagasonoda complexcomprisedofdextranmagnetiteandconjugatedcisplatinexhibitingselectivehyperthermicandcontrolledreleasepotential AT norihisanitta complexcomprisedofdextranmagnetiteandconjugatedcisplatinexhibitingselectivehyperthermicandcontrolledreleasepotential AT ayuminittaseko complexcomprisedofdextranmagnetiteandconjugatedcisplatinexhibitingselectivehyperthermicandcontrolledreleasepotential AT etal complexcomprisedofdextranmagnetiteandconjugatedcisplatinexhibitingselectivehyperthermicandcontrolledreleasepotential
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Complex comprised of dextran magnetite and conjugated cisplatin exhibiting selective hyperthermic and controlled-release potential

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