The association between impairment of HDL cholesterol efflux capacity and atrial remodeling in atrial fibrillation
Abstract This cross-sectional study enrolled 202 patients with atrial fibrillation (AF) who had undergone catheter ablation and evaluated the association between high-density lipoprotein (HDL) functionality, cholesterol efflux capacity (CEC) of HDL, and the pathophysiology of left atrial structural...
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Nature Portfolio
2021
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oai:doaj.org-article:2ca51ab487054380827ae9faef2078fb2021-12-02T13:30:28ZThe association between impairment of HDL cholesterol efflux capacity and atrial remodeling in atrial fibrillation10.1038/s41598-021-82998-42045-2322https://doaj.org/article/2ca51ab487054380827ae9faef2078fb2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82998-4https://doaj.org/toc/2045-2322Abstract This cross-sectional study enrolled 202 patients with atrial fibrillation (AF) who had undergone catheter ablation and evaluated the association between high-density lipoprotein (HDL) functionality, cholesterol efflux capacity (CEC) of HDL, and the pathophysiology of left atrial structural remodeling. Participants were divided into two groups, based on their left atrial volume index (LAVI) (< 34 mL/m2, n = 60 vs. LAVI ≥ 34 mL/m2, n = 142). We quantified three types of HDL CECs by the presence or absence of cyclic-AMP, as entire, and CEC dependent or not dependent on ATP binding cassette transporter A1 (ABCA1) and termed them Global CEC, ABCA1 CEC, and Non-ABCA1 CEC, respectively. Consequently, Global and Non-ABCA1 CECs were significantly impaired in patients with an enlarged LA (Global CEC: p = 0.039, Non-ABCA1 CEC: p = 0.022). Logistic regression analyses demonstrated that Non-ABCA1 CEC was significantly associated with an enlarged LA after adjusting for the conventional risk factors of AF. Furthermore, the association of higher Non-ABCA1 CEC with an enlarged LA was independent of serum levels of HDL cholesterol and serum myeloperoxidase (Odds ratio of 1 standard deviation higher: 0.64, 95% confidence interval: 0.43–0.95, p = 0.027). The findings of this study indicate the potential contribution of reduced Non-ABCA1 CEC in HDL to the pathophysiology in left atrial structural remodeling of patients with AF.Asuka Minami-TakanoHiroshi IwataKatsutoshi MiyosawaTomoyuki ShiozawaHidemori HayashiTakehiro FunamizuKai IshiiYui NozakiHaruna TabuchiGaku SekitaKazunori ShimadaMasataka SumiyoshiYuji NakazatoHiroyuki DaidaTohru MinaminoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
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Medicine R Science Q Asuka Minami-Takano Hiroshi Iwata Katsutoshi Miyosawa Tomoyuki Shiozawa Hidemori Hayashi Takehiro Funamizu Kai Ishii Yui Nozaki Haruna Tabuchi Gaku Sekita Kazunori Shimada Masataka Sumiyoshi Yuji Nakazato Hiroyuki Daida Tohru Minamino The association between impairment of HDL cholesterol efflux capacity and atrial remodeling in atrial fibrillation |
| description |
Abstract This cross-sectional study enrolled 202 patients with atrial fibrillation (AF) who had undergone catheter ablation and evaluated the association between high-density lipoprotein (HDL) functionality, cholesterol efflux capacity (CEC) of HDL, and the pathophysiology of left atrial structural remodeling. Participants were divided into two groups, based on their left atrial volume index (LAVI) (< 34 mL/m2, n = 60 vs. LAVI ≥ 34 mL/m2, n = 142). We quantified three types of HDL CECs by the presence or absence of cyclic-AMP, as entire, and CEC dependent or not dependent on ATP binding cassette transporter A1 (ABCA1) and termed them Global CEC, ABCA1 CEC, and Non-ABCA1 CEC, respectively. Consequently, Global and Non-ABCA1 CECs were significantly impaired in patients with an enlarged LA (Global CEC: p = 0.039, Non-ABCA1 CEC: p = 0.022). Logistic regression analyses demonstrated that Non-ABCA1 CEC was significantly associated with an enlarged LA after adjusting for the conventional risk factors of AF. Furthermore, the association of higher Non-ABCA1 CEC with an enlarged LA was independent of serum levels of HDL cholesterol and serum myeloperoxidase (Odds ratio of 1 standard deviation higher: 0.64, 95% confidence interval: 0.43–0.95, p = 0.027). The findings of this study indicate the potential contribution of reduced Non-ABCA1 CEC in HDL to the pathophysiology in left atrial structural remodeling of patients with AF. |
| format |
article |
| author |
Asuka Minami-Takano Hiroshi Iwata Katsutoshi Miyosawa Tomoyuki Shiozawa Hidemori Hayashi Takehiro Funamizu Kai Ishii Yui Nozaki Haruna Tabuchi Gaku Sekita Kazunori Shimada Masataka Sumiyoshi Yuji Nakazato Hiroyuki Daida Tohru Minamino |
| author_facet |
Asuka Minami-Takano Hiroshi Iwata Katsutoshi Miyosawa Tomoyuki Shiozawa Hidemori Hayashi Takehiro Funamizu Kai Ishii Yui Nozaki Haruna Tabuchi Gaku Sekita Kazunori Shimada Masataka Sumiyoshi Yuji Nakazato Hiroyuki Daida Tohru Minamino |
| author_sort |
Asuka Minami-Takano |
| title |
The association between impairment of HDL cholesterol efflux capacity and atrial remodeling in atrial fibrillation |
| title_short |
The association between impairment of HDL cholesterol efflux capacity and atrial remodeling in atrial fibrillation |
| title_full |
The association between impairment of HDL cholesterol efflux capacity and atrial remodeling in atrial fibrillation |
| title_fullStr |
The association between impairment of HDL cholesterol efflux capacity and atrial remodeling in atrial fibrillation |
| title_full_unstemmed |
The association between impairment of HDL cholesterol efflux capacity and atrial remodeling in atrial fibrillation |
| title_sort |
association between impairment of hdl cholesterol efflux capacity and atrial remodeling in atrial fibrillation |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/2ca51ab487054380827ae9faef2078fb |
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