The effect of stimulants on irritability in autism comorbid with ADHD: a systematic review

Ahmad Ghanizadeh,1,2 Mohammed Molla,2 Garth Jon Olango21Research Center for Psychiatry and Behavioral Sciences, Department of Psychiatry, Shiraz University of Medical Sciences, Shiraz, Iran; 2Department of Psychiatry, UCLA-Kern Psychiatry Residency Program, Kern Medical, Kern Behavioral Health and R...

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Autores principales:	Ghanizadeh A, Molla M, Olango GJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Autistic Disorder Attention Deficit Disorder with Hyperactivity Central Nervous System Stimulants Irritable Mood Comorbidity Methylphenidate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/2ca6e448299c4b0c9c4b8119f425e772
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spelling	oai:doaj.org-article:2ca6e448299c4b0c9c4b8119f425e7722021-12-02T09:24:37ZThe effect of stimulants on irritability in autism comorbid with ADHD: a systematic review1178-2021https://doaj.org/article/2ca6e448299c4b0c9c4b8119f425e7722019-06-01T00:00:00Zhttps://www.dovepress.com/the-effect-of-stimulants-on-irritability-in-autism-comorbid-with-adhd--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ahmad Ghanizadeh,1,2 Mohammed Molla,2 Garth Jon Olango21Research Center for Psychiatry and Behavioral Sciences, Department of Psychiatry, Shiraz University of Medical Sciences, Shiraz, Iran; 2Department of Psychiatry, UCLA-Kern Psychiatry Residency Program, Kern Medical, Kern Behavioral Health and Recovery Services, Bakersfield, CA, USAIntroduction: While there is a very high rate of comorbidity of autism and ADHD, there are controversies about prescribing stimulants in children with autism. This is a systematic review about the effect of stimulants on irritability in children with both autism and ADHD.Methods: A systematic review was conducted to study the possible effect of stimulants on irritability in autism and ADHD using the databases of PubMed, Scopus, EMBASE, and ScienceDirect in September 2018. Eligible clinical trials of stimulants in the treatment of Autism and ADHD without restriction of language were included. The primary outcome was irritability score. The full texts of relevant articles were studied, and their references were scanned for any possible related article.Results: Out of 1,315 citations, there were 26 relevant articles. Of the relevant articles, 16 were not interventional studies and were excluded. There were 10 interventional studies. None of them considered irritability as a main outcome. Also, none of them studied the effect of stimulants on irritability in autism plus ADHD. Current uncontrolled evidence about the association of stimulants with irritability is controversial.Conclusion: The current evidence is not enough to support or discourage the effect of stimulants on irritability in children and adolescents with both autism and ADHD. Well-designed controlled clinical trials need to be conducted for this ignored research area.Keywords: autistic disorder, attention deficit disorder with hyperactivity, central nervous system stimulants, irritable mood, comorbidity, methylphenidateGhanizadeh AMolla MOlango GJDove Medical PressarticleAutistic DisorderAttention Deficit Disorder with HyperactivityCentral Nervous System StimulantsIrritable MoodComorbidityMethylphenidateNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1547-1555 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Autistic Disorder Attention Deficit Disorder with Hyperactivity Central Nervous System Stimulants Irritable Mood Comorbidity Methylphenidate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Autistic Disorder Attention Deficit Disorder with Hyperactivity Central Nervous System Stimulants Irritable Mood Comorbidity Methylphenidate Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ghanizadeh A Molla M Olango GJ The effect of stimulants on irritability in autism comorbid with ADHD: a systematic review
description	Ahmad Ghanizadeh,1,2 Mohammed Molla,2 Garth Jon Olango21Research Center for Psychiatry and Behavioral Sciences, Department of Psychiatry, Shiraz University of Medical Sciences, Shiraz, Iran; 2Department of Psychiatry, UCLA-Kern Psychiatry Residency Program, Kern Medical, Kern Behavioral Health and Recovery Services, Bakersfield, CA, USAIntroduction: While there is a very high rate of comorbidity of autism and ADHD, there are controversies about prescribing stimulants in children with autism. This is a systematic review about the effect of stimulants on irritability in children with both autism and ADHD.Methods: A systematic review was conducted to study the possible effect of stimulants on irritability in autism and ADHD using the databases of PubMed, Scopus, EMBASE, and ScienceDirect in September 2018. Eligible clinical trials of stimulants in the treatment of Autism and ADHD without restriction of language were included. The primary outcome was irritability score. The full texts of relevant articles were studied, and their references were scanned for any possible related article.Results: Out of 1,315 citations, there were 26 relevant articles. Of the relevant articles, 16 were not interventional studies and were excluded. There were 10 interventional studies. None of them considered irritability as a main outcome. Also, none of them studied the effect of stimulants on irritability in autism plus ADHD. Current uncontrolled evidence about the association of stimulants with irritability is controversial.Conclusion: The current evidence is not enough to support or discourage the effect of stimulants on irritability in children and adolescents with both autism and ADHD. Well-designed controlled clinical trials need to be conducted for this ignored research area.Keywords: autistic disorder, attention deficit disorder with hyperactivity, central nervous system stimulants, irritable mood, comorbidity, methylphenidate
format	article
author	Ghanizadeh A Molla M Olango GJ
author_facet	Ghanizadeh A Molla M Olango GJ
author_sort	Ghanizadeh A
title	The effect of stimulants on irritability in autism comorbid with ADHD: a systematic review
title_short	The effect of stimulants on irritability in autism comorbid with ADHD: a systematic review
title_full	The effect of stimulants on irritability in autism comorbid with ADHD: a systematic review
title_fullStr	The effect of stimulants on irritability in autism comorbid with ADHD: a systematic review
title_full_unstemmed	The effect of stimulants on irritability in autism comorbid with ADHD: a systematic review
title_sort	effect of stimulants on irritability in autism comorbid with adhd: a systematic review
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/2ca6e448299c4b0c9c4b8119f425e772
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The effect of stimulants on irritability in autism comorbid with ADHD: a systematic review

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