Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells

Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells

Abstract Loss of primary cilia in cells deficient for the tumor suppressor von Hippel Lindau (VHL) arise from elevated Aurora Kinase A (AURKA) levels. VHL in its role as an E3 ubiquitin ligase targets AURKA for degradation and in the absence of VHL, high levels of AURKA result in destabilization of...

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Autores principales: Pratim Chowdhury, Dimuthu Perera, Reid T. Powell, Tia Talley, Durga Nand Tripathi, Yong Sung Park, Michael A. Mancini, Peter Davies, Clifford Stephan, Cristian Corfa, Ruhee Dere
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/2ca73e95c5024ae6a9c8ae5e0e85611a
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