Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila

Heteroplasmy, in which mutant and wild-type mitochondrial DNA (mtDNA) coexist in a cell, can result in diseases. Here the authors generate transgenic flies with heteroplasmic mtDNA in flight muscles, and show that stimulation of autophagy, or a decrease in mitofusin, promotes clearance of mutant mtD...

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Autores principales:	Nikolay P. Kandul, Ting Zhang, Bruce A. Hay, Ming Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ca95c300f824197acd6122632dd826c
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spelling	oai:doaj.org-article:2ca95c300f824197acd6122632dd826c2021-12-02T17:33:09ZSelective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila10.1038/ncomms131002041-1723https://doaj.org/article/2ca95c300f824197acd6122632dd826c2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13100https://doaj.org/toc/2041-1723Heteroplasmy, in which mutant and wild-type mitochondrial DNA (mtDNA) coexist in a cell, can result in diseases. Here the authors generate transgenic flies with heteroplasmic mtDNA in flight muscles, and show that stimulation of autophagy, or a decrease in mitofusin, promotes clearance of mutant mtDNA.Nikolay P. KandulTing ZhangBruce A. HayMing GuoNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nikolay P. Kandul Ting Zhang Bruce A. Hay Ming Guo Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila
description	Heteroplasmy, in which mutant and wild-type mitochondrial DNA (mtDNA) coexist in a cell, can result in diseases. Here the authors generate transgenic flies with heteroplasmic mtDNA in flight muscles, and show that stimulation of autophagy, or a decrease in mitofusin, promotes clearance of mutant mtDNA.
format	article
author	Nikolay P. Kandul Ting Zhang Bruce A. Hay Ming Guo
author_facet	Nikolay P. Kandul Ting Zhang Bruce A. Hay Ming Guo
author_sort	Nikolay P. Kandul
title	Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila
title_short	Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila
title_full	Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila
title_fullStr	Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila
title_full_unstemmed	Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila
title_sort	selective removal of deletion-bearing mitochondrial dna in heteroplasmic drosophila
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2ca95c300f824197acd6122632dd826c
work_keys_str_mv	AT nikolaypkandul selectiveremovalofdeletionbearingmitochondrialdnainheteroplasmicdrosophila AT tingzhang selectiveremovalofdeletionbearingmitochondrialdnainheteroplasmicdrosophila AT bruceahay selectiveremovalofdeletionbearingmitochondrialdnainheteroplasmicdrosophila AT mingguo selectiveremovalofdeletionbearingmitochondrialdnainheteroplasmicdrosophila
_version_	1718380053349269504

Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila

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