Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects

Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face of variations in genetic background, chemical tre...

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Autores principales: Mark Lucanic, W. Todd Plummer, Esteban Chen, Jailynn Harke, Anna C. Foulger, Brian Onken, Anna L. Coleman-Hulbert, Kathleen J. Dumas, Suzhen Guo, Erik Johnson, Dipa Bhaumik, Jian Xue, Anna B. Crist, Michael P. Presley, Girish Harinath, Christine A. Sedore, Manish Chamoli, Shaunak Kamat, Michelle K. Chen, Suzanne Angeli, Christina Chang, John H. Willis, Daniel Edgar, Mary Anne Royal, Elizabeth A. Chao, Shobhna Patel, Theo Garrett, Carolina Ibanez-Ventoso, June Hope, Jason L Kish, Max Guo, Gordon J. Lithgow, Monica Driscoll, Patrick C. Phillips
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/2cab827465544f808fc531ab3590aa8a
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spelling oai:doaj.org-article:2cab827465544f808fc531ab3590aa8a2021-12-02T15:38:32ZImpact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects10.1038/ncomms142562041-1723https://doaj.org/article/2cab827465544f808fc531ab3590aa8a2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14256https://doaj.org/toc/2041-1723Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face of variations in genetic background, chemical treatment and lab environment.Mark LucanicW. Todd PlummerEsteban ChenJailynn HarkeAnna C. FoulgerBrian OnkenAnna L. Coleman-HulbertKathleen J. DumasSuzhen GuoErik JohnsonDipa BhaumikJian XueAnna B. CristMichael P. PresleyGirish HarinathChristine A. SedoreManish ChamoliShaunak KamatMichelle K. ChenSuzanne AngeliChristina ChangJohn H. WillisDaniel EdgarMary Anne RoyalElizabeth A. ChaoShobhna PatelTheo GarrettCarolina Ibanez-VentosoJune HopeJason L KishMax GuoGordon J. LithgowMonica DriscollPatrick C. PhillipsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mark Lucanic
W. Todd Plummer
Esteban Chen
Jailynn Harke
Anna C. Foulger
Brian Onken
Anna L. Coleman-Hulbert
Kathleen J. Dumas
Suzhen Guo
Erik Johnson
Dipa Bhaumik
Jian Xue
Anna B. Crist
Michael P. Presley
Girish Harinath
Christine A. Sedore
Manish Chamoli
Shaunak Kamat
Michelle K. Chen
Suzanne Angeli
Christina Chang
John H. Willis
Daniel Edgar
Mary Anne Royal
Elizabeth A. Chao
Shobhna Patel
Theo Garrett
Carolina Ibanez-Ventoso
June Hope
Jason L Kish
Max Guo
Gordon J. Lithgow
Monica Driscoll
Patrick C. Phillips
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
description Irreproducibility of biological findings is a major challenge for drug development. Here the authors examine the lifespans of 22 worm strains in three different laboratories and the effects of ten known chemicals to assess reproducibility in the face of variations in genetic background, chemical treatment and lab environment.
format article
author Mark Lucanic
W. Todd Plummer
Esteban Chen
Jailynn Harke
Anna C. Foulger
Brian Onken
Anna L. Coleman-Hulbert
Kathleen J. Dumas
Suzhen Guo
Erik Johnson
Dipa Bhaumik
Jian Xue
Anna B. Crist
Michael P. Presley
Girish Harinath
Christine A. Sedore
Manish Chamoli
Shaunak Kamat
Michelle K. Chen
Suzanne Angeli
Christina Chang
John H. Willis
Daniel Edgar
Mary Anne Royal
Elizabeth A. Chao
Shobhna Patel
Theo Garrett
Carolina Ibanez-Ventoso
June Hope
Jason L Kish
Max Guo
Gordon J. Lithgow
Monica Driscoll
Patrick C. Phillips
author_facet Mark Lucanic
W. Todd Plummer
Esteban Chen
Jailynn Harke
Anna C. Foulger
Brian Onken
Anna L. Coleman-Hulbert
Kathleen J. Dumas
Suzhen Guo
Erik Johnson
Dipa Bhaumik
Jian Xue
Anna B. Crist
Michael P. Presley
Girish Harinath
Christine A. Sedore
Manish Chamoli
Shaunak Kamat
Michelle K. Chen
Suzanne Angeli
Christina Chang
John H. Willis
Daniel Edgar
Mary Anne Royal
Elizabeth A. Chao
Shobhna Patel
Theo Garrett
Carolina Ibanez-Ventoso
June Hope
Jason L Kish
Max Guo
Gordon J. Lithgow
Monica Driscoll
Patrick C. Phillips
author_sort Mark Lucanic
title Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
title_short Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
title_full Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
title_fullStr Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
title_full_unstemmed Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
title_sort impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/2cab827465544f808fc531ab3590aa8a
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