Effect of Euphorbia Helioscopia Extract on Acute and Chronic Pain in Mice

BACKGROUND AND OBJECTIVE: Most of analgesics have side effects and introducing new drugs is essential. Euphorbia helioscopia is a medicinal plant which is used by people in Chaharmahal Bakhtiary province of Iran as a painkiller. This experiment was performed to study the analgesic effect of an alco...

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Autores principales:	M Shirani, Z Alibabaei, S Kheiri, H Shirzad, F Taji, A Asgari, M Rafieian
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2011
Materias:	pain medicinal plant mouse euphorbia helioscopia Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2cabc8bd7e2246e78113530a41eaba0d
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id	oai:doaj.org-article:2cabc8bd7e2246e78113530a41eaba0d
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spelling	oai:doaj.org-article:2cabc8bd7e2246e78113530a41eaba0d2021-11-10T08:56:42ZEffect of Euphorbia Helioscopia Extract on Acute and Chronic Pain in Mice1561-41072251-7170https://doaj.org/article/2cabc8bd7e2246e78113530a41eaba0d2011-07-01T00:00:00Zhttp://jbums.org/article-1-3836-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Most of analgesics have side effects and introducing new drugs is essential. Euphorbia helioscopia is a medicinal plant which is used by people in Chaharmahal Bakhtiary province of Iran as a painkiller. This experiment was performed to study the analgesic effect of an alcoholic extract from the aerial parts of Euphorbia helioscopia by formalin test.METHODS: In an experimental study 100 Balb/c mice were divided into 10 groups as follows: group 1 received distilled water, group 2 to 7 received 0.05, 0.1, 0.2, 0.4, 2 and 8mg/mouse of alcoholic extract, respectively. Group 8 received 6 mg/kg ibuprofen, group 9, 1 mg/kg naloxone and group 10 received naloxone and extract. The pain-related behavior was counted for a period of 30 min, following injection of 20 microliter of 1.5% formalin. The data obtained in case groups were compared with the ones in control group. The plant was extracted by maceration method using ethanol 96%. The extract was then concentrated and reconstructed in normal saline to produce different desired concentrations. FINDINGS: In the first 5 minutes (acute period) of the experiment 8mg/mouse of the extract and in the following 25 minutes, 0.1 and 8mg/mouse of the extract reduced pain reaction, compared to control group (p<0.05). Naloxone had no effect on this effect of the extract. CONCLUSION: Euphorbia helioscopia has antinociceptive activity that is not due to interaction with opioid system.M ShiraniZ AlibabaeiS KheiriH ShirzadF TajiA AsgariM RafieianBabol University of Medical Sciencesarticlepainmedicinal plantmouseeuphorbia helioscopiaMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 13, Iss 4, Pp 14-18 (2011)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	pain medicinal plant mouse euphorbia helioscopia Medicine R Medicine (General) R5-920
spellingShingle	pain medicinal plant mouse euphorbia helioscopia Medicine R Medicine (General) R5-920 M Shirani Z Alibabaei S Kheiri H Shirzad F Taji A Asgari M Rafieian Effect of Euphorbia Helioscopia Extract on Acute and Chronic Pain in Mice
description	BACKGROUND AND OBJECTIVE: Most of analgesics have side effects and introducing new drugs is essential. Euphorbia helioscopia is a medicinal plant which is used by people in Chaharmahal Bakhtiary province of Iran as a painkiller. This experiment was performed to study the analgesic effect of an alcoholic extract from the aerial parts of Euphorbia helioscopia by formalin test.METHODS: In an experimental study 100 Balb/c mice were divided into 10 groups as follows: group 1 received distilled water, group 2 to 7 received 0.05, 0.1, 0.2, 0.4, 2 and 8mg/mouse of alcoholic extract, respectively. Group 8 received 6 mg/kg ibuprofen, group 9, 1 mg/kg naloxone and group 10 received naloxone and extract. The pain-related behavior was counted for a period of 30 min, following injection of 20 microliter of 1.5% formalin. The data obtained in case groups were compared with the ones in control group. The plant was extracted by maceration method using ethanol 96%. The extract was then concentrated and reconstructed in normal saline to produce different desired concentrations. FINDINGS: In the first 5 minutes (acute period) of the experiment 8mg/mouse of the extract and in the following 25 minutes, 0.1 and 8mg/mouse of the extract reduced pain reaction, compared to control group (p<0.05). Naloxone had no effect on this effect of the extract. CONCLUSION: Euphorbia helioscopia has antinociceptive activity that is not due to interaction with opioid system.
format	article
author	M Shirani Z Alibabaei S Kheiri H Shirzad F Taji A Asgari M Rafieian
author_facet	M Shirani Z Alibabaei S Kheiri H Shirzad F Taji A Asgari M Rafieian
author_sort	M Shirani
title	Effect of Euphorbia Helioscopia Extract on Acute and Chronic Pain in Mice
title_short	Effect of Euphorbia Helioscopia Extract on Acute and Chronic Pain in Mice
title_full	Effect of Euphorbia Helioscopia Extract on Acute and Chronic Pain in Mice
title_fullStr	Effect of Euphorbia Helioscopia Extract on Acute and Chronic Pain in Mice
title_full_unstemmed	Effect of Euphorbia Helioscopia Extract on Acute and Chronic Pain in Mice
title_sort	effect of euphorbia helioscopia extract on acute and chronic pain in mice
publisher	Babol University of Medical Sciences
publishDate	2011
url	https://doaj.org/article/2cabc8bd7e2246e78113530a41eaba0d
work_keys_str_mv	AT mshirani effectofeuphorbiahelioscopiaextractonacuteandchronicpaininmice AT zalibabaei effectofeuphorbiahelioscopiaextractonacuteandchronicpaininmice AT skheiri effectofeuphorbiahelioscopiaextractonacuteandchronicpaininmice AT hshirzad effectofeuphorbiahelioscopiaextractonacuteandchronicpaininmice AT ftaji effectofeuphorbiahelioscopiaextractonacuteandchronicpaininmice AT aasgari effectofeuphorbiahelioscopiaextractonacuteandchronicpaininmice AT mrafieian effectofeuphorbiahelioscopiaextractonacuteandchronicpaininmice
_version_	1718440268662833152

Effect of Euphorbia Helioscopia Extract on Acute and Chronic Pain in Mice

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