BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects

Stress-induced glucocorticoids cause mitochondrial damage in neurons, but they are not cleared by mitophagy. Here, the authors show that glucocorticoids inhibit NIX-dependent basal mitophagy, contributing to neurodegeneration in a mouse model that can be reversed by pretreatment with a NIX enhancer.

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Autores principales:	Gee Euhn Choi, Hyun Jik Lee, Chang Woo Chae, Ji Hyeon Cho, Young Hyun Jung, Jun Sung Kim, Seo Yihl Kim, Jae Ryong Lim, Ho Jae Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2cac894c75774d089073e5f07a58c03c
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spelling	oai:doaj.org-article:2cac894c75774d089073e5f07a58c03c2021-12-02T13:51:03ZBNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects10.1038/s41467-020-20679-y2041-1723https://doaj.org/article/2cac894c75774d089073e5f07a58c03c2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20679-yhttps://doaj.org/toc/2041-1723Stress-induced glucocorticoids cause mitochondrial damage in neurons, but they are not cleared by mitophagy. Here, the authors show that glucocorticoids inhibit NIX-dependent basal mitophagy, contributing to neurodegeneration in a mouse model that can be reversed by pretreatment with a NIX enhancer.Gee Euhn ChoiHyun Jik LeeChang Woo ChaeJi Hyeon ChoYoung Hyun JungJun Sung KimSeo Yihl KimJae Ryong LimHo Jae HanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gee Euhn Choi Hyun Jik Lee Chang Woo Chae Ji Hyeon Cho Young Hyun Jung Jun Sung Kim Seo Yihl Kim Jae Ryong Lim Ho Jae Han BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects
description	Stress-induced glucocorticoids cause mitochondrial damage in neurons, but they are not cleared by mitophagy. Here, the authors show that glucocorticoids inhibit NIX-dependent basal mitophagy, contributing to neurodegeneration in a mouse model that can be reversed by pretreatment with a NIX enhancer.
format	article
author	Gee Euhn Choi Hyun Jik Lee Chang Woo Chae Ji Hyeon Cho Young Hyun Jung Jun Sung Kim Seo Yihl Kim Jae Ryong Lim Ho Jae Han
author_facet	Gee Euhn Choi Hyun Jik Lee Chang Woo Chae Ji Hyeon Cho Young Hyun Jung Jun Sung Kim Seo Yihl Kim Jae Ryong Lim Ho Jae Han
author_sort	Gee Euhn Choi
title	BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects
title_short	BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects
title_full	BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects
title_fullStr	BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects
title_full_unstemmed	BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects
title_sort	bnip3l/nix-mediated mitophagy protects against glucocorticoid-induced synapse defects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2cac894c75774d089073e5f07a58c03c
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BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects

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