Ethanol intake in male mice exposed to social defeat: Environmental enrichment potentiates resilience

Large preclinical evidence shows that exposure to social defeat (SD) increases vulnerability to drug abuse, increasing the consumption of ethanol. However, not all subjects are equally affected by the changes induced by stress. Previous reports have evidenced that the resilient phenotype to depressi...

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Autores principales:	Marina D. Reguilón, Carmen Ferrer-Pérez, Carmen Manzanedo, José Miñarro, Marta Rodríguez-Arias
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Neuroinflammation Social defeat Ethanol Susceptibility Resilience Environmental enrichment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/2cae987380c64f2c9ebcc3c548ebcc5a
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spelling	oai:doaj.org-article:2cae987380c64f2c9ebcc3c548ebcc5a2021-11-10T04:27:56ZEthanol intake in male mice exposed to social defeat: Environmental enrichment potentiates resilience2352-289510.1016/j.ynstr.2021.100413https://doaj.org/article/2cae987380c64f2c9ebcc3c548ebcc5a2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352289521001211https://doaj.org/toc/2352-2895Large preclinical evidence shows that exposure to social defeat (SD) increases vulnerability to drug abuse, increasing the consumption of ethanol. However, not all subjects are equally affected by the changes induced by stress. Previous reports have evidenced that the resilient phenotype to depressive-like behaviors after SD is associated with the resistant phenotype to cocaine-increased rewarding effects and the smaller neuroinflammatory response. The aim of the present study was to further clarify whether the resilient profile to depressive-like behavior also predicts a protection against the increase in ethanol intake induced by SD. The neuroinflammatory profile was studied after the end of the oral ethanol self-administration (SA) procedure, measuring levels of the pro-inflammatory cytokine IL-6 and the chemokine CX3CL1 or fractalkine in the striatum and prefrontal cortex. Previous studies have shown that environmental enrichment (EE) is an effective mechanism to dimish the detrimental effects of social stress. In a second study, we aimed to evaluate if EE housing before exposure to SD could potentiate resilience. Our results showed that mice with a phenotype susceptible to SD-induced depressive-like behaviors showed increased ethanol consumption and increased neuroinflammatory signaling. In contrast, despite the lack of effect on depressive-like behaviors, defeated mice previously housed under EE conditions did not show an increase in ethanol SA or an increase in immune response. To sum up, the resilient phenotype to SD develops at different levels, such as depressive-like behaviors, ethanol consumption and the neuroinflammatory response. Our results also point to the protective role of EE in potentiating resilience to SD effects.Marina D. ReguilónCarmen Ferrer-PérezCarmen ManzanedoJosé MiñarroMarta Rodríguez-AriasElsevierarticleNeuroinflammationSocial defeatEthanolSusceptibilityResilienceEnvironmental enrichmentNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429Neurophysiology and neuropsychologyQP351-495ENNeurobiology of Stress, Vol 15, Iss , Pp 100413- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neuroinflammation Social defeat Ethanol Susceptibility Resilience Environmental enrichment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Neurophysiology and neuropsychology QP351-495
spellingShingle	Neuroinflammation Social defeat Ethanol Susceptibility Resilience Environmental enrichment Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Neurophysiology and neuropsychology QP351-495 Marina D. Reguilón Carmen Ferrer-Pérez Carmen Manzanedo José Miñarro Marta Rodríguez-Arias Ethanol intake in male mice exposed to social defeat: Environmental enrichment potentiates resilience
description	Large preclinical evidence shows that exposure to social defeat (SD) increases vulnerability to drug abuse, increasing the consumption of ethanol. However, not all subjects are equally affected by the changes induced by stress. Previous reports have evidenced that the resilient phenotype to depressive-like behaviors after SD is associated with the resistant phenotype to cocaine-increased rewarding effects and the smaller neuroinflammatory response. The aim of the present study was to further clarify whether the resilient profile to depressive-like behavior also predicts a protection against the increase in ethanol intake induced by SD. The neuroinflammatory profile was studied after the end of the oral ethanol self-administration (SA) procedure, measuring levels of the pro-inflammatory cytokine IL-6 and the chemokine CX3CL1 or fractalkine in the striatum and prefrontal cortex. Previous studies have shown that environmental enrichment (EE) is an effective mechanism to dimish the detrimental effects of social stress. In a second study, we aimed to evaluate if EE housing before exposure to SD could potentiate resilience. Our results showed that mice with a phenotype susceptible to SD-induced depressive-like behaviors showed increased ethanol consumption and increased neuroinflammatory signaling. In contrast, despite the lack of effect on depressive-like behaviors, defeated mice previously housed under EE conditions did not show an increase in ethanol SA or an increase in immune response. To sum up, the resilient phenotype to SD develops at different levels, such as depressive-like behaviors, ethanol consumption and the neuroinflammatory response. Our results also point to the protective role of EE in potentiating resilience to SD effects.
format	article
author	Marina D. Reguilón Carmen Ferrer-Pérez Carmen Manzanedo José Miñarro Marta Rodríguez-Arias
author_facet	Marina D. Reguilón Carmen Ferrer-Pérez Carmen Manzanedo José Miñarro Marta Rodríguez-Arias
author_sort	Marina D. Reguilón
title	Ethanol intake in male mice exposed to social defeat: Environmental enrichment potentiates resilience
title_short	Ethanol intake in male mice exposed to social defeat: Environmental enrichment potentiates resilience
title_full	Ethanol intake in male mice exposed to social defeat: Environmental enrichment potentiates resilience
title_fullStr	Ethanol intake in male mice exposed to social defeat: Environmental enrichment potentiates resilience
title_full_unstemmed	Ethanol intake in male mice exposed to social defeat: Environmental enrichment potentiates resilience
title_sort	ethanol intake in male mice exposed to social defeat: environmental enrichment potentiates resilience
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/2cae987380c64f2c9ebcc3c548ebcc5a
work_keys_str_mv	AT marinadreguilon ethanolintakeinmalemiceexposedtosocialdefeatenvironmentalenrichmentpotentiatesresilience AT carmenferrerperez ethanolintakeinmalemiceexposedtosocialdefeatenvironmentalenrichmentpotentiatesresilience AT carmenmanzanedo ethanolintakeinmalemiceexposedtosocialdefeatenvironmentalenrichmentpotentiatesresilience AT joseminarro ethanolintakeinmalemiceexposedtosocialdefeatenvironmentalenrichmentpotentiatesresilience AT martarodriguezarias ethanolintakeinmalemiceexposedtosocialdefeatenvironmentalenrichmentpotentiatesresilience
_version_	1718440635767193600

Ethanol intake in male mice exposed to social defeat: Environmental enrichment potentiates resilience

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