Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate

Pa Fan Hsiao,1–3 Sydney Peng,4 Ting-Cheng Tang,4 Shuian-Yin Lin,5 Hsieh-Chih Tsai4 1Department of Dermatology, Mackay Memorial Hospital, 2Mackay Medicine, Nursing and Management College, 3Mackay Medical College, New Taipei City, 4Graduate Institute of Applied Science and Technology, Natio...

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Autores principales:	Hsiao PF, Peng S, Tang TC, Lin SY, Tsai HC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Skin penetration amphiphilic copolymer gold nanoparticle oleylamine poly(ethylene glycol) Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2cb0884550fd49debad945638efcf0bd
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spelling	oai:doaj.org-article:2cb0884550fd49debad945638efcf0bd2021-12-02T00:09:56ZEnhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate1178-2013https://doaj.org/article/2cb0884550fd49debad945638efcf0bd2016-05-01T00:00:00Zhttps://www.dovepress.com/enhancing-the-in-vivo-transdermal-delivery-of-gold-nanoparticles-using-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Pa Fan Hsiao,1–3 Sydney Peng,4 Ting-Cheng Tang,4 Shuian-Yin Lin,5 Hsieh-Chih Tsai4 1Department of Dermatology, Mackay Memorial Hospital, 2Mackay Medicine, Nursing and Management College, 3Mackay Medical College, New Taipei City, 4Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, 5National Applied Research Laboratories, Instrument Technology Research Center, Hsinchu, Taiwan Abstract: In this study, we investigated the effect of (ethylene glycol) (PEG) and PEG–oleylamine (OAm) functionalization on the skin permeation property of gold nanoparticles (GNS) in vivo. Chemisorption of polymers onto GNS was verified by a red shift in the ultraviolet–visible spectrum as well as by a change in the nanoparticle surface charge. The physicochemical properties of pristine and functionalized nanoparticles were analyzed by ultraviolet–visible spectroscopy, zeta potential analyzer, and transmission electron microscopy. Transmission electron microscopy revealed that the interparticle distance between nanoparticles increased after GNS functionalization. Comparing the skin permeation profile of pristine and functionalized GNS, the follicular deposition of GNS increased twofold after PEG–OAm functionalization. Moreover, PEG- and PEG–OAm-functionalized nanoparticles were able to overcome the skin barrier and deposit in the deeper subcutaneous adipose tissue. These findings demonstrate the potential of PEG- and PEG–OAm-functionalized GNS in serving a multitude of applications in transdermal pharmaceuticals. Keywords: skin penetration, amphiphilic copolymer, gold nanoparticle, oleylamine, poly(ethylene glycol)Hsiao PFPeng STang TCLin SYTsai HCDove Medical PressarticleSkin penetrationamphiphilic copolymergold nanoparticleoleylaminepoly(ethylene glycol)Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 1867-1878 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Skin penetration amphiphilic copolymer gold nanoparticle oleylamine poly(ethylene glycol) Medicine (General) R5-920
spellingShingle	Skin penetration amphiphilic copolymer gold nanoparticle oleylamine poly(ethylene glycol) Medicine (General) R5-920 Hsiao PF Peng S Tang TC Lin SY Tsai HC Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate
description	Pa Fan Hsiao,1–3 Sydney Peng,4 Ting-Cheng Tang,4 Shuian-Yin Lin,5 Hsieh-Chih Tsai4 1Department of Dermatology, Mackay Memorial Hospital, 2Mackay Medicine, Nursing and Management College, 3Mackay Medical College, New Taipei City, 4Graduate Institute of Applied Science and Technology, National Taiwan University of Science and Technology, Taipei, 5National Applied Research Laboratories, Instrument Technology Research Center, Hsinchu, Taiwan Abstract: In this study, we investigated the effect of (ethylene glycol) (PEG) and PEG–oleylamine (OAm) functionalization on the skin permeation property of gold nanoparticles (GNS) in vivo. Chemisorption of polymers onto GNS was verified by a red shift in the ultraviolet–visible spectrum as well as by a change in the nanoparticle surface charge. The physicochemical properties of pristine and functionalized nanoparticles were analyzed by ultraviolet–visible spectroscopy, zeta potential analyzer, and transmission electron microscopy. Transmission electron microscopy revealed that the interparticle distance between nanoparticles increased after GNS functionalization. Comparing the skin permeation profile of pristine and functionalized GNS, the follicular deposition of GNS increased twofold after PEG–OAm functionalization. Moreover, PEG- and PEG–OAm-functionalized nanoparticles were able to overcome the skin barrier and deposit in the deeper subcutaneous adipose tissue. These findings demonstrate the potential of PEG- and PEG–OAm-functionalized GNS in serving a multitude of applications in transdermal pharmaceuticals. Keywords: skin penetration, amphiphilic copolymer, gold nanoparticle, oleylamine, poly(ethylene glycol)
format	article
author	Hsiao PF Peng S Tang TC Lin SY Tsai HC
author_facet	Hsiao PF Peng S Tang TC Lin SY Tsai HC
author_sort	Hsiao PF
title	Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate
title_short	Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate
title_full	Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate
title_fullStr	Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate
title_full_unstemmed	Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate
title_sort	enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/2cb0884550fd49debad945638efcf0bd
work_keys_str_mv	AT hsiaopf enhancingtheinvivotransdermaldeliveryofgoldnanoparticlesusingpolyethyleneglycolanditsoleylamineconjugate AT pengs enhancingtheinvivotransdermaldeliveryofgoldnanoparticlesusingpolyethyleneglycolanditsoleylamineconjugate AT tangtc enhancingtheinvivotransdermaldeliveryofgoldnanoparticlesusingpolyethyleneglycolanditsoleylamineconjugate AT linsy enhancingtheinvivotransdermaldeliveryofgoldnanoparticlesusingpolyethyleneglycolanditsoleylamineconjugate AT tsaihc enhancingtheinvivotransdermaldeliveryofgoldnanoparticlesusingpolyethyleneglycolanditsoleylamineconjugate
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Enhancing the in vivo transdermal delivery of gold nanoparticles using poly(ethylene glycol) and its oleylamine conjugate

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