Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing

Tissues-specific gene expression requires coordinated cis-regulatory elements. Here the authors use dCas9-based enhancer targeting to remodel local epigenetic landscapes and activate or inactive transcription.

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Autores principales:	Kailong Li, Yuxuan Liu, Hui Cao, Yuannyu Zhang, Zhimin Gu, Xin Liu, Andy Yu, Pranita Kaphle, Kathryn E. Dickerson, Min Ni, Jian Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2cb1b72f1c3c452abe1b2b0d54ed6d78
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spelling	oai:doaj.org-article:2cb1b72f1c3c452abe1b2b0d54ed6d782021-12-02T15:39:13ZInterrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing10.1038/s41467-020-14362-52041-1723https://doaj.org/article/2cb1b72f1c3c452abe1b2b0d54ed6d782020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14362-5https://doaj.org/toc/2041-1723Tissues-specific gene expression requires coordinated cis-regulatory elements. Here the authors use dCas9-based enhancer targeting to remodel local epigenetic landscapes and activate or inactive transcription.Kailong LiYuxuan LiuHui CaoYuannyu ZhangZhimin GuXin LiuAndy YuPranita KaphleKathryn E. DickersonMin NiJian XuNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kailong Li Yuxuan Liu Hui Cao Yuannyu Zhang Zhimin Gu Xin Liu Andy Yu Pranita Kaphle Kathryn E. Dickerson Min Ni Jian Xu Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing
description	Tissues-specific gene expression requires coordinated cis-regulatory elements. Here the authors use dCas9-based enhancer targeting to remodel local epigenetic landscapes and activate or inactive transcription.
format	article
author	Kailong Li Yuxuan Liu Hui Cao Yuannyu Zhang Zhimin Gu Xin Liu Andy Yu Pranita Kaphle Kathryn E. Dickerson Min Ni Jian Xu
author_facet	Kailong Li Yuxuan Liu Hui Cao Yuannyu Zhang Zhimin Gu Xin Liu Andy Yu Pranita Kaphle Kathryn E. Dickerson Min Ni Jian Xu
author_sort	Kailong Li
title	Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing
title_short	Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing
title_full	Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing
title_fullStr	Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing
title_full_unstemmed	Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing
title_sort	interrogation of enhancer function by enhancer-targeting crispr epigenetic editing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2cb1b72f1c3c452abe1b2b0d54ed6d78
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Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing

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