Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling

The authors use a forward genetic screen to discover postsynaptic factors required for homeostatic synaptic plasticity at the Drosophila neuromuscular junction. They identify insomniac and the ubiquitin ligase Cul3, genes involved in sleep regulation, to be necessary for retrograde homeostatic signa...

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Autores principales:	Koto Kikuma, Xiling Li, Sarah Perry, Qiuling Li, Pragya Goel, Catherine Chen, Daniel Kim, Nicholas Stavropoulos, Dion Dickman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2cb2b85d249444b7998b0a2f3b6dca98
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spelling	oai:doaj.org-article:2cb2b85d249444b7998b0a2f3b6dca982021-12-02T14:38:36ZCul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling10.1038/s41467-019-10992-62041-1723https://doaj.org/article/2cb2b85d249444b7998b0a2f3b6dca982019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10992-6https://doaj.org/toc/2041-1723The authors use a forward genetic screen to discover postsynaptic factors required for homeostatic synaptic plasticity at the Drosophila neuromuscular junction. They identify insomniac and the ubiquitin ligase Cul3, genes involved in sleep regulation, to be necessary for retrograde homeostatic signalling at this synapse.Koto KikumaXiling LiSarah PerryQiuling LiPragya GoelCatherine ChenDaniel KimNicholas StavropoulosDion DickmanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Koto Kikuma Xiling Li Sarah Perry Qiuling Li Pragya Goel Catherine Chen Daniel Kim Nicholas Stavropoulos Dion Dickman Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling
description	The authors use a forward genetic screen to discover postsynaptic factors required for homeostatic synaptic plasticity at the Drosophila neuromuscular junction. They identify insomniac and the ubiquitin ligase Cul3, genes involved in sleep regulation, to be necessary for retrograde homeostatic signalling at this synapse.
format	article
author	Koto Kikuma Xiling Li Sarah Perry Qiuling Li Pragya Goel Catherine Chen Daniel Kim Nicholas Stavropoulos Dion Dickman
author_facet	Koto Kikuma Xiling Li Sarah Perry Qiuling Li Pragya Goel Catherine Chen Daniel Kim Nicholas Stavropoulos Dion Dickman
author_sort	Koto Kikuma
title	Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling
title_short	Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling
title_full	Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling
title_fullStr	Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling
title_full_unstemmed	Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling
title_sort	cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/2cb2b85d249444b7998b0a2f3b6dca98
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Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling

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