Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression

Engineered T cells with chimeric antigen receptor (CAR) are emerging as an effective cancer therapy. Here the authors show that CAR T cells recognizing self-MHC can be ‘tuned’ ex vivo via CAR downregulation and CAR T cell death to generate a CAR T pool specifically targeting tumor cells with high MH...

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Autores principales:	Chungyong Han, Su-Jung Sim, Seon-Hee Kim, Rohit Singh, Sunhee Hwang, Yu I. Kim, Sang H. Park, Kwang H. Kim, Don G. Lee, Ho S. Oh, Sangeun Lee, Young H. Kim, Beom K. Choi, Byoung S. Kwon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2cb448a0b80d4a85bfbe75a3ddee2e23
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spelling	oai:doaj.org-article:2cb448a0b80d4a85bfbe75a3ddee2e232021-12-02T14:40:10ZDesensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression10.1038/s41467-018-02912-x2041-1723https://doaj.org/article/2cb448a0b80d4a85bfbe75a3ddee2e232018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02912-xhttps://doaj.org/toc/2041-1723Engineered T cells with chimeric antigen receptor (CAR) are emerging as an effective cancer therapy. Here the authors show that CAR T cells recognizing self-MHC can be ‘tuned’ ex vivo via CAR downregulation and CAR T cell death to generate a CAR T pool specifically targeting tumor cells with high MHC expression.Chungyong HanSu-Jung SimSeon-Hee KimRohit SinghSunhee HwangYu I. KimSang H. ParkKwang H. KimDon G. LeeHo S. OhSangeun LeeYoung H. KimBeom K. ChoiByoung S. KwonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chungyong Han Su-Jung Sim Seon-Hee Kim Rohit Singh Sunhee Hwang Yu I. Kim Sang H. Park Kwang H. Kim Don G. Lee Ho S. Oh Sangeun Lee Young H. Kim Beom K. Choi Byoung S. Kwon Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
description	Engineered T cells with chimeric antigen receptor (CAR) are emerging as an effective cancer therapy. Here the authors show that CAR T cells recognizing self-MHC can be ‘tuned’ ex vivo via CAR downregulation and CAR T cell death to generate a CAR T pool specifically targeting tumor cells with high MHC expression.
format	article
author	Chungyong Han Su-Jung Sim Seon-Hee Kim Rohit Singh Sunhee Hwang Yu I. Kim Sang H. Park Kwang H. Kim Don G. Lee Ho S. Oh Sangeun Lee Young H. Kim Beom K. Choi Byoung S. Kwon
author_facet	Chungyong Han Su-Jung Sim Seon-Hee Kim Rohit Singh Sunhee Hwang Yu I. Kim Sang H. Park Kwang H. Kim Don G. Lee Ho S. Oh Sangeun Lee Young H. Kim Beom K. Choi Byoung S. Kwon
author_sort	Chungyong Han
title	Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
title_short	Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
title_full	Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
title_fullStr	Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
title_full_unstemmed	Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression
title_sort	desensitized chimeric antigen receptor t cells selectively recognize target cells with enhanced antigen expression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2cb448a0b80d4a85bfbe75a3ddee2e23
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Desensitized chimeric antigen receptor T cells selectively recognize target cells with enhanced antigen expression

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