A xanthene derivative, DS20060511, attenuates glucose intolerance by inducing skeletal muscle-specific GLUT4 translocation in mice

Furuzono et al. identify DS20060511, a skeletal muscle cell-specific GLUT4 translocation enhancer. They find that DS20060511 have remarkable effects on lowering blood glucose and enhancing skeletal muscle glucose uptake via GLUT4, highlighting its potential as antidiabetic medicine.

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Autores principales: Shinji Furuzono, Tetsuya Kubota, Junki Taura, Masahiro Konishi, Asuka Naito, Masato Tsutsui, Hiroshi Karasawa, Naoto Kubota, Takashi Kadowaki
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2cbb8b9c1de048938471e2d57c2bf08b
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spelling oai:doaj.org-article:2cbb8b9c1de048938471e2d57c2bf08b2021-12-02T16:46:33ZA xanthene derivative, DS20060511, attenuates glucose intolerance by inducing skeletal muscle-specific GLUT4 translocation in mice10.1038/s42003-021-02491-62399-3642https://doaj.org/article/2cbb8b9c1de048938471e2d57c2bf08b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02491-6https://doaj.org/toc/2399-3642Furuzono et al. identify DS20060511, a skeletal muscle cell-specific GLUT4 translocation enhancer. They find that DS20060511 have remarkable effects on lowering blood glucose and enhancing skeletal muscle glucose uptake via GLUT4, highlighting its potential as antidiabetic medicine.Shinji FuruzonoTetsuya KubotaJunki TauraMasahiro KonishiAsuka NaitoMasato TsutsuiHiroshi KarasawaNaoto KubotaTakashi KadowakiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Shinji Furuzono
Tetsuya Kubota
Junki Taura
Masahiro Konishi
Asuka Naito
Masato Tsutsui
Hiroshi Karasawa
Naoto Kubota
Takashi Kadowaki
A xanthene derivative, DS20060511, attenuates glucose intolerance by inducing skeletal muscle-specific GLUT4 translocation in mice
description Furuzono et al. identify DS20060511, a skeletal muscle cell-specific GLUT4 translocation enhancer. They find that DS20060511 have remarkable effects on lowering blood glucose and enhancing skeletal muscle glucose uptake via GLUT4, highlighting its potential as antidiabetic medicine.
format article
author Shinji Furuzono
Tetsuya Kubota
Junki Taura
Masahiro Konishi
Asuka Naito
Masato Tsutsui
Hiroshi Karasawa
Naoto Kubota
Takashi Kadowaki
author_facet Shinji Furuzono
Tetsuya Kubota
Junki Taura
Masahiro Konishi
Asuka Naito
Masato Tsutsui
Hiroshi Karasawa
Naoto Kubota
Takashi Kadowaki
author_sort Shinji Furuzono
title A xanthene derivative, DS20060511, attenuates glucose intolerance by inducing skeletal muscle-specific GLUT4 translocation in mice
title_short A xanthene derivative, DS20060511, attenuates glucose intolerance by inducing skeletal muscle-specific GLUT4 translocation in mice
title_full A xanthene derivative, DS20060511, attenuates glucose intolerance by inducing skeletal muscle-specific GLUT4 translocation in mice
title_fullStr A xanthene derivative, DS20060511, attenuates glucose intolerance by inducing skeletal muscle-specific GLUT4 translocation in mice
title_full_unstemmed A xanthene derivative, DS20060511, attenuates glucose intolerance by inducing skeletal muscle-specific GLUT4 translocation in mice
title_sort xanthene derivative, ds20060511, attenuates glucose intolerance by inducing skeletal muscle-specific glut4 translocation in mice
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2cbb8b9c1de048938471e2d57c2bf08b
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