PD-L1 is an activation-independent marker of brown adipocytes

PD-L1 is an activation-independent marker of brown adipocytes

Current approaches to visualise brown adipose tissue (BAT) rely primarily on markers that reflect its metabolic activity. Here, the authors show that PD-L1 is expressed on brown adipocytes, does not change upon BAT activation, and that BAT volume in mice can be measured by PET-CT with a radiolabeled...

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Autores principales: Jessica R. Ingram, Michael Dougan, Mohammad Rashidian, Marko Knoll, Edmund J. Keliher, Sarah Garrett, Scott Garforth, Olga S. Blomberg, Camilo Espinosa, Atul Bhan, Steven C. Almo, Ralph Weissleder, Harvey Lodish, Stephanie K. Dougan, Hidde L. Ploegh
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/2cbbcd069f884ad59674351eae9c1223
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spelling oai:doaj.org-article:2cbbcd069f884ad59674351eae9c12232021-12-02T14:40:33ZPD-L1 is an activation-independent marker of brown adipocytes10.1038/s41467-017-00799-82041-1723https://doaj.org/article/2cbbcd069f884ad59674351eae9c12232017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00799-8https://doaj.org/toc/2041-1723Current approaches to visualise brown adipose tissue (BAT) rely primarily on markers that reflect its metabolic activity. Here, the authors show that PD-L1 is expressed on brown adipocytes, does not change upon BAT activation, and that BAT volume in mice can be measured by PET-CT with a radiolabeled anti-PD-L1 antibody.Jessica R. IngramMichael DouganMohammad RashidianMarko KnollEdmund J. KeliherSarah GarrettScott GarforthOlga S. BlombergCamilo EspinosaAtul BhanSteven C. AlmoRalph WeisslederHarvey LodishStephanie K. DouganHidde L. PloeghNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jessica R. Ingram
Michael Dougan
Mohammad Rashidian
Marko Knoll
Edmund J. Keliher
Sarah Garrett
Scott Garforth
Olga S. Blomberg
Camilo Espinosa
Atul Bhan
Steven C. Almo
Ralph Weissleder
Harvey Lodish
Stephanie K. Dougan
Hidde L. Ploegh
PD-L1 is an activation-independent marker of brown adipocytes
description Current approaches to visualise brown adipose tissue (BAT) rely primarily on markers that reflect its metabolic activity. Here, the authors show that PD-L1 is expressed on brown adipocytes, does not change upon BAT activation, and that BAT volume in mice can be measured by PET-CT with a radiolabeled anti-PD-L1 antibody.
format article
author Jessica R. Ingram
Michael Dougan
Mohammad Rashidian
Marko Knoll
Edmund J. Keliher
Sarah Garrett
Scott Garforth
Olga S. Blomberg
Camilo Espinosa
Atul Bhan
Steven C. Almo
Ralph Weissleder
Harvey Lodish
Stephanie K. Dougan
Hidde L. Ploegh
author_facet Jessica R. Ingram
Michael Dougan
Mohammad Rashidian
Marko Knoll
Edmund J. Keliher
Sarah Garrett
Scott Garforth
Olga S. Blomberg
Camilo Espinosa
Atul Bhan
Steven C. Almo
Ralph Weissleder
Harvey Lodish
Stephanie K. Dougan
Hidde L. Ploegh
author_sort Jessica R. Ingram
title PD-L1 is an activation-independent marker of brown adipocytes
title_short PD-L1 is an activation-independent marker of brown adipocytes
title_full PD-L1 is an activation-independent marker of brown adipocytes
title_fullStr PD-L1 is an activation-independent marker of brown adipocytes
title_full_unstemmed PD-L1 is an activation-independent marker of brown adipocytes
title_sort pd-l1 is an activation-independent marker of brown adipocytes
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/2cbbcd069f884ad59674351eae9c1223
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