Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement

Abstract In our aging society, research into neurodegenerative processes is of great interest. Thereby, cortical activation under different neurocognitive conditions is considered to be a promising predictor. Against this background, the executive functions of a total of 250 healthy older adults (53...

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Autores principales:	Leonore Blum, David Rosenbaum, Benjamin Röben, Katja Dehnen, Walter Maetzler, Ulrike Suenkel, Andreas J. Fallgatter, Ann-Christine Ehlis, Florian G. Metzger
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2cbd7198ed7f48588be083df940a3d8b
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spelling	oai:doaj.org-article:2cbd7198ed7f48588be083df940a3d8b2021-12-02T16:36:12ZAge-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement10.1038/s41598-021-85762-w2045-2322https://doaj.org/article/2cbd7198ed7f48588be083df940a3d8b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85762-whttps://doaj.org/toc/2045-2322Abstract In our aging society, research into neurodegenerative processes is of great interest. Thereby, cortical activation under different neurocognitive conditions is considered to be a promising predictor. Against this background, the executive functions of a total of 250 healthy older adults (53–84 years) have been investigated using the Trail Making Test (TMT) and functional near-infrared spectroscopy in a block design. We investigated effects of age on the performance and cortical blood oxygenation during the TMT. Since it is assumed that older people may compensate for cognitive deficits by slowing their processing speed, we additionally analyzed the cortical blood oxygenation per solved item. Our results showed a significant decrease in processing speed in older participants compared to middle-aged individuals, however, also lower error rates during TMT part A. On a neurophysiological level, we observed increased cortical blood oxygenation in the older participants when completing the TMT. Finally, with respect to the combined measurement (O2Hb/item), no significantly higher hemodynamic cortical response per item was found within the older participants. The results confirm a deterioration of cognitive performance and an increase of cortical activity with increasing age. The findings are discussed in the light of current research.Leonore BlumDavid RosenbaumBenjamin RöbenKatja DehnenWalter MaetzlerUlrike SuenkelAndreas J. FallgatterAnn-Christine EhlisFlorian G. MetzgerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Leonore Blum David Rosenbaum Benjamin Röben Katja Dehnen Walter Maetzler Ulrike Suenkel Andreas J. Fallgatter Ann-Christine Ehlis Florian G. Metzger Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement
description	Abstract In our aging society, research into neurodegenerative processes is of great interest. Thereby, cortical activation under different neurocognitive conditions is considered to be a promising predictor. Against this background, the executive functions of a total of 250 healthy older adults (53–84 years) have been investigated using the Trail Making Test (TMT) and functional near-infrared spectroscopy in a block design. We investigated effects of age on the performance and cortical blood oxygenation during the TMT. Since it is assumed that older people may compensate for cognitive deficits by slowing their processing speed, we additionally analyzed the cortical blood oxygenation per solved item. Our results showed a significant decrease in processing speed in older participants compared to middle-aged individuals, however, also lower error rates during TMT part A. On a neurophysiological level, we observed increased cortical blood oxygenation in the older participants when completing the TMT. Finally, with respect to the combined measurement (O2Hb/item), no significantly higher hemodynamic cortical response per item was found within the older participants. The results confirm a deterioration of cognitive performance and an increase of cortical activity with increasing age. The findings are discussed in the light of current research.
format	article
author	Leonore Blum David Rosenbaum Benjamin Röben Katja Dehnen Walter Maetzler Ulrike Suenkel Andreas J. Fallgatter Ann-Christine Ehlis Florian G. Metzger
author_facet	Leonore Blum David Rosenbaum Benjamin Röben Katja Dehnen Walter Maetzler Ulrike Suenkel Andreas J. Fallgatter Ann-Christine Ehlis Florian G. Metzger
author_sort	Leonore Blum
title	Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement
title_short	Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement
title_full	Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement
title_fullStr	Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement
title_full_unstemmed	Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement
title_sort	age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fnirs measurement
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2cbd7198ed7f48588be083df940a3d8b
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Age-related deterioration of performance and increase of cortex activity comparing time- versus item-controlled fNIRS measurement

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