Forcing the reversibility of a mechanochemical reaction

Mechanical force can facilitate thermodynamically unfavourable reactions. Here, the authors found that a stretching force can promote the SN2 cleavage of a protein disulfide bond by weak nucleophilic thiols, and that removing this force reverses the reaction yielding the original disulfide bond.

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Autores principales:	Amy E. M. Beedle, Marc Mora, Colin T. Davis, Ambrosius P. Snijders, Guillaume Stirnemann, Sergi Garcia-Manyes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2cbe03a88f0e4c9ea6271c72af65ffeb
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spelling	oai:doaj.org-article:2cbe03a88f0e4c9ea6271c72af65ffeb2021-12-02T17:32:16ZForcing the reversibility of a mechanochemical reaction10.1038/s41467-018-05115-62041-1723https://doaj.org/article/2cbe03a88f0e4c9ea6271c72af65ffeb2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05115-6https://doaj.org/toc/2041-1723Mechanical force can facilitate thermodynamically unfavourable reactions. Here, the authors found that a stretching force can promote the SN2 cleavage of a protein disulfide bond by weak nucleophilic thiols, and that removing this force reverses the reaction yielding the original disulfide bond.Amy E. M. BeedleMarc MoraColin T. DavisAmbrosius P. SnijdersGuillaume StirnemannSergi Garcia-ManyesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Amy E. M. Beedle Marc Mora Colin T. Davis Ambrosius P. Snijders Guillaume Stirnemann Sergi Garcia-Manyes Forcing the reversibility of a mechanochemical reaction
description	Mechanical force can facilitate thermodynamically unfavourable reactions. Here, the authors found that a stretching force can promote the SN2 cleavage of a protein disulfide bond by weak nucleophilic thiols, and that removing this force reverses the reaction yielding the original disulfide bond.
format	article
author	Amy E. M. Beedle Marc Mora Colin T. Davis Ambrosius P. Snijders Guillaume Stirnemann Sergi Garcia-Manyes
author_facet	Amy E. M. Beedle Marc Mora Colin T. Davis Ambrosius P. Snijders Guillaume Stirnemann Sergi Garcia-Manyes
author_sort	Amy E. M. Beedle
title	Forcing the reversibility of a mechanochemical reaction
title_short	Forcing the reversibility of a mechanochemical reaction
title_full	Forcing the reversibility of a mechanochemical reaction
title_fullStr	Forcing the reversibility of a mechanochemical reaction
title_full_unstemmed	Forcing the reversibility of a mechanochemical reaction
title_sort	forcing the reversibility of a mechanochemical reaction
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2cbe03a88f0e4c9ea6271c72af65ffeb
work_keys_str_mv	AT amyembeedle forcingthereversibilityofamechanochemicalreaction AT marcmora forcingthereversibilityofamechanochemicalreaction AT colintdavis forcingthereversibilityofamechanochemicalreaction AT ambrosiuspsnijders forcingthereversibilityofamechanochemicalreaction AT guillaumestirnemann forcingthereversibilityofamechanochemicalreaction AT sergigarciamanyes forcingthereversibilityofamechanochemicalreaction
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Forcing the reversibility of a mechanochemical reaction

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