Comparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder

Abstract Purpose The purpose of this study is to compare dynamic and static whole-body (WB) [18F]NaF PET/CT scan methods used for analysis of bone plasma clearance in patients with chronic kidney disease-mineral and bone disorder (CKD-MBD). Methods Seventeen patients with CKD-MBD underwent a 60-min...

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Autores principales:	M. H. Vrist, J. N. Bech, T. G. Lauridsen, C. A. Fynbo, J. Theil
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	NaF PET/CT Hawkins Patlak Semi-population input function CKD-MBD Medical physics. Medical radiology. Nuclear medicine R895-920
Acceso en línea:	https://doaj.org/article/2cbea32a13a84afaaf5f5413531eb5d6
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spelling	oai:doaj.org-article:2cbea32a13a84afaaf5f5413531eb5d62021-11-28T12:15:09ZComparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder10.1186/s13550-021-00859-72191-219Xhttps://doaj.org/article/2cbea32a13a84afaaf5f5413531eb5d62021-11-01T00:00:00Zhttps://doi.org/10.1186/s13550-021-00859-7https://doaj.org/toc/2191-219XAbstract Purpose The purpose of this study is to compare dynamic and static whole-body (WB) [18F]NaF PET/CT scan methods used for analysis of bone plasma clearance in patients with chronic kidney disease-mineral and bone disorder (CKD-MBD). Methods Seventeen patients with CKD-MBD underwent a 60-min dynamic scan followed by a 30-min static WB scan. Tracer kinetics in four thoracic vertebrae were analysed using nonlinear regression and Patlak analysis using image-derived arterial input functions. The static WB scan was analysed using a simplified Patlak method requiring only a single data point in combination with a fixed y-intercept value (V 0), both obtained using a semi-population function. The semi-population function was constructed by combining a previously derived population input function in combination with data from venous blood samples. Static WB scan analysis data, obtained from the semi-population input functions, was compared with paired data obtained using dynamic input functions. Results Bone plasma clearance (K i) from Patlak analyses correlated well with nonlinear regression analysis, but K i results using Patlak analysis were lower than K i results using nonlinear regression analysis. However, no significant difference was found between K i obtained by static WB scans and K i obtained by dynamic scans using nonlinear regression analysis (p = 0.29). Conclusion Bone plasma clearance measured from static WB scans correlates with clearance data measured by dynamic analysis. Static [18F]NaF PET/CT scans can be applied in future studies to measure Ki in patients with CKD-MBD, but the results should not be compared uncritically with results obtained by dynamic scan analysis.M. H. VristJ. N. BechT. G. LauridsenC. A. FynboJ. TheilSpringerOpenarticleNaFPET/CTHawkinsPatlakSemi-population input functionCKD-MBDMedical physics. Medical radiology. Nuclear medicineR895-920ENEJNMMI Research, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NaF PET/CT Hawkins Patlak Semi-population input function CKD-MBD Medical physics. Medical radiology. Nuclear medicine R895-920
spellingShingle	NaF PET/CT Hawkins Patlak Semi-population input function CKD-MBD Medical physics. Medical radiology. Nuclear medicine R895-920 M. H. Vrist J. N. Bech T. G. Lauridsen C. A. Fynbo J. Theil Comparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder
description	Abstract Purpose The purpose of this study is to compare dynamic and static whole-body (WB) [18F]NaF PET/CT scan methods used for analysis of bone plasma clearance in patients with chronic kidney disease-mineral and bone disorder (CKD-MBD). Methods Seventeen patients with CKD-MBD underwent a 60-min dynamic scan followed by a 30-min static WB scan. Tracer kinetics in four thoracic vertebrae were analysed using nonlinear regression and Patlak analysis using image-derived arterial input functions. The static WB scan was analysed using a simplified Patlak method requiring only a single data point in combination with a fixed y-intercept value (V 0), both obtained using a semi-population function. The semi-population function was constructed by combining a previously derived population input function in combination with data from venous blood samples. Static WB scan analysis data, obtained from the semi-population input functions, was compared with paired data obtained using dynamic input functions. Results Bone plasma clearance (K i) from Patlak analyses correlated well with nonlinear regression analysis, but K i results using Patlak analysis were lower than K i results using nonlinear regression analysis. However, no significant difference was found between K i obtained by static WB scans and K i obtained by dynamic scans using nonlinear regression analysis (p = 0.29). Conclusion Bone plasma clearance measured from static WB scans correlates with clearance data measured by dynamic analysis. Static [18F]NaF PET/CT scans can be applied in future studies to measure Ki in patients with CKD-MBD, but the results should not be compared uncritically with results obtained by dynamic scan analysis.
format	article
author	M. H. Vrist J. N. Bech T. G. Lauridsen C. A. Fynbo J. Theil
author_facet	M. H. Vrist J. N. Bech T. G. Lauridsen C. A. Fynbo J. Theil
author_sort	M. H. Vrist
title	Comparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder
title_short	Comparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder
title_full	Comparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder
title_fullStr	Comparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder
title_full_unstemmed	Comparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder
title_sort	comparison of [18f] naf pet/ct dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/2cbea32a13a84afaaf5f5413531eb5d6
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Comparison of [18F] NaF PET/CT dynamic analysis methods and a static analysis method including derivation of a semi-population input function for site-specific measurements of bone formation in a population with chronic kidney disease-mineral and bone disorder

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