Beneficial Effects of Vitamin E Supplementation on Endothelial Dysfunction, Inflammation, and Oxidative Stress Biomarkers in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Inflammation and oxidative stress are closely related to cardiovascular complications and atherosclerosis, and have the potential to lead to an increase in death in patients receiving hemodialysis. Vitamin E has antioxidant and anti-inflammatory properties. We conducted a systematic review and meta-...

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Autores principales:	Thi Thuy Uyen Nguyen, Ji-hyun Yeom, Won Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vitamin E endothelial dysfunction inflammation oxidative stress hemodialysis Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/2cc04e66925e4488be372afc4747c467
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spelling	oai:doaj.org-article:2cc04e66925e4488be372afc4747c4672021-11-11T17:20:21ZBeneficial Effects of Vitamin E Supplementation on Endothelial Dysfunction, Inflammation, and Oxidative Stress Biomarkers in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials10.3390/ijms2221119231422-00671661-6596https://doaj.org/article/2cc04e66925e4488be372afc4747c4672021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11923https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Inflammation and oxidative stress are closely related to cardiovascular complications and atherosclerosis, and have the potential to lead to an increase in death in patients receiving hemodialysis. Vitamin E has antioxidant and anti-inflammatory properties. We conducted a systematic review and meta-analysis to assess the effects of vitamin E supplementation on endothelial dysfunction, inflammation, and oxidative stress biomarkers in adult patients receiving hemodialysis. We searched the MEDLINE, EMBASE, Web of Science, and Cochrane Library databases and identified randomized controlled trials of adult patients receiving hemodialysis until 30 August 2021. A total of 11 trials with 491 randomized patients were included. The pooled data indicated that vitamin E supplementation significantly decreased intercellular adhesion molecule-1 [standardized mean difference (SMD): −1.35; 95% confidence interval (CI): −2.57, −0.13; <i>p</i> = 0.03, I<sup>2</sup> = 89%], vascular cell adhesion molecule-1 (SMD: −1.08; 95% CI: −2.05, −0.11; <i>p</i> = 0.03, I<sup>2</sup> = 81%), C-reactive protein (SMD: −0.41; 95% CI: −0.75, −0.07; <i>p</i> = 0.02, I<sup>2</sup> = 64%), and malondialdehyde (SMD: −0.76; 95% CI: −1.26, −0.25; <i>p</i> = 0.003, I<sup>2</sup> = 77%) levels, but not interleukin-6 levels compared to those in the control group. Our results suggest that vitamin E supplementation may help alleviate oxidative stress and both vascular and systemic inflammation in patients receiving hemodialysis.Thi Thuy Uyen NguyenJi-hyun YeomWon KimMDPI AGarticlevitamin Eendothelial dysfunctioninflammationoxidative stresshemodialysisBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11923, p 11923 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin E endothelial dysfunction inflammation oxidative stress hemodialysis Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	vitamin E endothelial dysfunction inflammation oxidative stress hemodialysis Biology (General) QH301-705.5 Chemistry QD1-999 Thi Thuy Uyen Nguyen Ji-hyun Yeom Won Kim Beneficial Effects of Vitamin E Supplementation on Endothelial Dysfunction, Inflammation, and Oxidative Stress Biomarkers in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
description	Inflammation and oxidative stress are closely related to cardiovascular complications and atherosclerosis, and have the potential to lead to an increase in death in patients receiving hemodialysis. Vitamin E has antioxidant and anti-inflammatory properties. We conducted a systematic review and meta-analysis to assess the effects of vitamin E supplementation on endothelial dysfunction, inflammation, and oxidative stress biomarkers in adult patients receiving hemodialysis. We searched the MEDLINE, EMBASE, Web of Science, and Cochrane Library databases and identified randomized controlled trials of adult patients receiving hemodialysis until 30 August 2021. A total of 11 trials with 491 randomized patients were included. The pooled data indicated that vitamin E supplementation significantly decreased intercellular adhesion molecule-1 [standardized mean difference (SMD): −1.35; 95% confidence interval (CI): −2.57, −0.13; <i>p</i> = 0.03, I<sup>2</sup> = 89%], vascular cell adhesion molecule-1 (SMD: −1.08; 95% CI: −2.05, −0.11; <i>p</i> = 0.03, I<sup>2</sup> = 81%), C-reactive protein (SMD: −0.41; 95% CI: −0.75, −0.07; <i>p</i> = 0.02, I<sup>2</sup> = 64%), and malondialdehyde (SMD: −0.76; 95% CI: −1.26, −0.25; <i>p</i> = 0.003, I<sup>2</sup> = 77%) levels, but not interleukin-6 levels compared to those in the control group. Our results suggest that vitamin E supplementation may help alleviate oxidative stress and both vascular and systemic inflammation in patients receiving hemodialysis.
format	article
author	Thi Thuy Uyen Nguyen Ji-hyun Yeom Won Kim
author_facet	Thi Thuy Uyen Nguyen Ji-hyun Yeom Won Kim
author_sort	Thi Thuy Uyen Nguyen
title	Beneficial Effects of Vitamin E Supplementation on Endothelial Dysfunction, Inflammation, and Oxidative Stress Biomarkers in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_short	Beneficial Effects of Vitamin E Supplementation on Endothelial Dysfunction, Inflammation, and Oxidative Stress Biomarkers in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full	Beneficial Effects of Vitamin E Supplementation on Endothelial Dysfunction, Inflammation, and Oxidative Stress Biomarkers in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_fullStr	Beneficial Effects of Vitamin E Supplementation on Endothelial Dysfunction, Inflammation, and Oxidative Stress Biomarkers in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_full_unstemmed	Beneficial Effects of Vitamin E Supplementation on Endothelial Dysfunction, Inflammation, and Oxidative Stress Biomarkers in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
title_sort	beneficial effects of vitamin e supplementation on endothelial dysfunction, inflammation, and oxidative stress biomarkers in patients receiving hemodialysis: a systematic review and meta-analysis of randomized controlled trials
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2cc04e66925e4488be372afc4747c467
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Beneficial Effects of Vitamin E Supplementation on Endothelial Dysfunction, Inflammation, and Oxidative Stress Biomarkers in Patients Receiving Hemodialysis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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