Familial Ovarian Cancer Clusters with Other Cancers

Abstract Familial risk of ovarian cancer is well-established but whether ovarian cancer clusters with other cancers and the clusters differ by histology remains uncertain. Using data from the Swedish Family-Cancer Database, we explored familial associations of ovarian cancer with other cancers with...

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Autores principales:	Guoqiao Zheng, Hongyao Yu, Anna Kanerva, Asta Försti, Kristina Sundquist, Kari Hemminki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2cc634ba704c47afa34e40ff5a1dc6f0
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spelling	oai:doaj.org-article:2cc634ba704c47afa34e40ff5a1dc6f02021-12-02T15:08:29ZFamilial Ovarian Cancer Clusters with Other Cancers10.1038/s41598-018-29888-42045-2322https://doaj.org/article/2cc634ba704c47afa34e40ff5a1dc6f02018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29888-4https://doaj.org/toc/2045-2322Abstract Familial risk of ovarian cancer is well-established but whether ovarian cancer clusters with other cancers and the clusters differ by histology remains uncertain. Using data from the Swedish Family-Cancer Database, we explored familial associations of ovarian cancer with other cancers with a novel approach; relative risk for (histology-specific) ovarian cancer was estimated in families with patients affected by other cancers, and conversely, risks for other cancers in families with (histology-specific) ovarian cancer patients. Eight discordant cancers were associated with ovarian cancer risk, of which family history of breast cancer showed a dose-response (P-trend <0.0001). Conversely, risks of eight types of cancer increased in families with ovarian cancer patients, and dose-responses were shown for risks of liver (P-trend = 0.0083) and breast cancers (P-trend <0.0001) and cancer of unknown primary (P-trend = 0.0157). Some cancers were only associated with histology-specific ovarian cancers, e.g. endometrial cancer was only associated with endometrioid type but with highest significance. Novel associations with virus-linked cancers of the nose and male and female genitals were found. The results suggest that ovarian cancer shares susceptibility with a number of other cancers. This might alert genetic counselors and challenge approaches for gene and gene-environment identification.Guoqiao ZhengHongyao YuAnna KanervaAsta FörstiKristina SundquistKari HemminkiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guoqiao Zheng Hongyao Yu Anna Kanerva Asta Försti Kristina Sundquist Kari Hemminki Familial Ovarian Cancer Clusters with Other Cancers
description	Abstract Familial risk of ovarian cancer is well-established but whether ovarian cancer clusters with other cancers and the clusters differ by histology remains uncertain. Using data from the Swedish Family-Cancer Database, we explored familial associations of ovarian cancer with other cancers with a novel approach; relative risk for (histology-specific) ovarian cancer was estimated in families with patients affected by other cancers, and conversely, risks for other cancers in families with (histology-specific) ovarian cancer patients. Eight discordant cancers were associated with ovarian cancer risk, of which family history of breast cancer showed a dose-response (P-trend <0.0001). Conversely, risks of eight types of cancer increased in families with ovarian cancer patients, and dose-responses were shown for risks of liver (P-trend = 0.0083) and breast cancers (P-trend <0.0001) and cancer of unknown primary (P-trend = 0.0157). Some cancers were only associated with histology-specific ovarian cancers, e.g. endometrial cancer was only associated with endometrioid type but with highest significance. Novel associations with virus-linked cancers of the nose and male and female genitals were found. The results suggest that ovarian cancer shares susceptibility with a number of other cancers. This might alert genetic counselors and challenge approaches for gene and gene-environment identification.
format	article
author	Guoqiao Zheng Hongyao Yu Anna Kanerva Asta Försti Kristina Sundquist Kari Hemminki
author_facet	Guoqiao Zheng Hongyao Yu Anna Kanerva Asta Försti Kristina Sundquist Kari Hemminki
author_sort	Guoqiao Zheng
title	Familial Ovarian Cancer Clusters with Other Cancers
title_short	Familial Ovarian Cancer Clusters with Other Cancers
title_full	Familial Ovarian Cancer Clusters with Other Cancers
title_fullStr	Familial Ovarian Cancer Clusters with Other Cancers
title_full_unstemmed	Familial Ovarian Cancer Clusters with Other Cancers
title_sort	familial ovarian cancer clusters with other cancers
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2cc634ba704c47afa34e40ff5a1dc6f0
work_keys_str_mv	AT guoqiaozheng familialovariancancerclusterswithothercancers AT hongyaoyu familialovariancancerclusterswithothercancers AT annakanerva familialovariancancerclusterswithothercancers AT astaforsti familialovariancancerclusterswithothercancers AT kristinasundquist familialovariancancerclusterswithothercancers AT karihemminki familialovariancancerclusterswithothercancers
_version_	1718388113381785600

Familial Ovarian Cancer Clusters with Other Cancers

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