Individuals with controlled hypertension show endothelial integrity following a bout of moderate-intensity exercise: randomized clinical trial

Abstract To examine the acute effects of aerobic exercise (AE), resistance exercise (RE) or combined exercise (CE) on flow-mediated dilation (FMD), progenitor cells (PCs), endothelial progenitor cells (EPCs), oxidative stress markers and endothelial-cell derived microvesicles (EMVs) in patients with...

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Autores principales:	Gustavo Waclawovsky, Liliana F. C. Boll, Bruna Eibel, Ana Paula Alegretti, Fabiane Spagnol, Juliana De Paoli, Simone Wajner, Rafael A. Marschner, Maximiliano I. Schaun, Alexandre Machado Lehnen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2cc678c8e460443985afb1b4fe5a6b03
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spelling	oai:doaj.org-article:2cc678c8e460443985afb1b4fe5a6b032021-12-02T16:45:39ZIndividuals with controlled hypertension show endothelial integrity following a bout of moderate-intensity exercise: randomized clinical trial10.1038/s41598-021-87990-62045-2322https://doaj.org/article/2cc678c8e460443985afb1b4fe5a6b032021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87990-6https://doaj.org/toc/2045-2322Abstract To examine the acute effects of aerobic exercise (AE), resistance exercise (RE) or combined exercise (CE) on flow-mediated dilation (FMD), progenitor cells (PCs), endothelial progenitor cells (EPCs), oxidative stress markers and endothelial-cell derived microvesicles (EMVs) in patients with hypertension. This is a randomized, parallel-group clinical trial involving an intervention of one session of three different modalities of exercise. Thirty-three males (43 ± 2y) were randomly divided into three groups: a session of AE (n = 11, 40 min, cycle ergometer, 60% HRR); a session of RE (n = 11, 40 min, 4 × 12 lower limb repetitions, 60% 1-RM); or a session of CE (n = 11, 20-min RE + 20-min AE). FMD was assessed 10 min before and 10, 40 and 70 min post-intervention. Blood samples were collected at the same time points (except 40 min). FMD were similar in all groups and from baseline (within each group) after a single exercise bout (AE, RE or CE). At 70 min, RE group showed higher levels of PCs compared to the AE (81%) and CE group (60%). PC levels were reduced from baseline in all groups (AE: 32%, p = 0.037; RE: 15%, p = 0.003; CE: 17%, p = 0.048). The levels of EPCs, EMVs and oxidative stress were unchanged. There were no acute effects of moderate-intensity exercise on FMD, EPCs, EMVs and oxidative stress, but PCs decreased regardless of the exercise modality. Individuals with controlled hypertension do not seem to have impaired vascular function in response to a single exercise bout.Gustavo WaclawovskyLiliana F. C. BollBruna EibelAna Paula AlegrettiFabiane SpagnolJuliana De PaoliSimone WajnerRafael A. MarschnerMaximiliano I. SchaunAlexandre Machado LehnenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gustavo Waclawovsky Liliana F. C. Boll Bruna Eibel Ana Paula Alegretti Fabiane Spagnol Juliana De Paoli Simone Wajner Rafael A. Marschner Maximiliano I. Schaun Alexandre Machado Lehnen Individuals with controlled hypertension show endothelial integrity following a bout of moderate-intensity exercise: randomized clinical trial
description	Abstract To examine the acute effects of aerobic exercise (AE), resistance exercise (RE) or combined exercise (CE) on flow-mediated dilation (FMD), progenitor cells (PCs), endothelial progenitor cells (EPCs), oxidative stress markers and endothelial-cell derived microvesicles (EMVs) in patients with hypertension. This is a randomized, parallel-group clinical trial involving an intervention of one session of three different modalities of exercise. Thirty-three males (43 ± 2y) were randomly divided into three groups: a session of AE (n = 11, 40 min, cycle ergometer, 60% HRR); a session of RE (n = 11, 40 min, 4 × 12 lower limb repetitions, 60% 1-RM); or a session of CE (n = 11, 20-min RE + 20-min AE). FMD was assessed 10 min before and 10, 40 and 70 min post-intervention. Blood samples were collected at the same time points (except 40 min). FMD were similar in all groups and from baseline (within each group) after a single exercise bout (AE, RE or CE). At 70 min, RE group showed higher levels of PCs compared to the AE (81%) and CE group (60%). PC levels were reduced from baseline in all groups (AE: 32%, p = 0.037; RE: 15%, p = 0.003; CE: 17%, p = 0.048). The levels of EPCs, EMVs and oxidative stress were unchanged. There were no acute effects of moderate-intensity exercise on FMD, EPCs, EMVs and oxidative stress, but PCs decreased regardless of the exercise modality. Individuals with controlled hypertension do not seem to have impaired vascular function in response to a single exercise bout.
format	article
author	Gustavo Waclawovsky Liliana F. C. Boll Bruna Eibel Ana Paula Alegretti Fabiane Spagnol Juliana De Paoli Simone Wajner Rafael A. Marschner Maximiliano I. Schaun Alexandre Machado Lehnen
author_facet	Gustavo Waclawovsky Liliana F. C. Boll Bruna Eibel Ana Paula Alegretti Fabiane Spagnol Juliana De Paoli Simone Wajner Rafael A. Marschner Maximiliano I. Schaun Alexandre Machado Lehnen
author_sort	Gustavo Waclawovsky
title	Individuals with controlled hypertension show endothelial integrity following a bout of moderate-intensity exercise: randomized clinical trial
title_short	Individuals with controlled hypertension show endothelial integrity following a bout of moderate-intensity exercise: randomized clinical trial
title_full	Individuals with controlled hypertension show endothelial integrity following a bout of moderate-intensity exercise: randomized clinical trial
title_fullStr	Individuals with controlled hypertension show endothelial integrity following a bout of moderate-intensity exercise: randomized clinical trial
title_full_unstemmed	Individuals with controlled hypertension show endothelial integrity following a bout of moderate-intensity exercise: randomized clinical trial
title_sort	individuals with controlled hypertension show endothelial integrity following a bout of moderate-intensity exercise: randomized clinical trial
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2cc678c8e460443985afb1b4fe5a6b03
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Individuals with controlled hypertension show endothelial integrity following a bout of moderate-intensity exercise: randomized clinical trial

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