Permeability of Buccal Mucosa

The buccal mucosa provides an alternative route of drug delivery that can be more beneficial compared to other administration routes. Although numerous studies and reviews have been published on buccal drug delivery, an extensive review of the permeability data is not available. Understanding the bu...

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Autores principales:	Apipa Wanasathop, Priya B Patel, Hyojin A. Choi, S. Kevin Li
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	permeability buccal membrane drug delivery transport Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/2cccb91a51a34649a16f2367abb06788
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spelling	oai:doaj.org-article:2cccb91a51a34649a16f2367abb067882021-11-25T18:40:53ZPermeability of Buccal Mucosa10.3390/pharmaceutics131118141999-4923https://doaj.org/article/2cccb91a51a34649a16f2367abb067882021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1814https://doaj.org/toc/1999-4923The buccal mucosa provides an alternative route of drug delivery that can be more beneficial compared to other administration routes. Although numerous studies and reviews have been published on buccal drug delivery, an extensive review of the permeability data is not available. Understanding the buccal mucosa barrier could provide insights into the approaches to effective drug delivery and optimization of dosage forms. This paper provides a review on the permeability of the buccal mucosa. The intrinsic permeability coefficients of porcine buccal mucosa were collected. Large variability was observed among the published permeability data. The permeability coefficients were then analyzed using a model involving parallel lipoidal and polar transport pathways. For the lipoidal pathway, a correlation was observed between the permeability coefficients and permeant octanol/water partition coefficients (<i>K<sub>ow</sub></i>) and molecular weight (MW) in a subset of the permeability data under specific conditions. The permeability analysis suggested that the buccal permeation barrier was less lipophilic than octanol. For the polar pathway and macromolecules, a correlation was observed between the permeability coefficients and permeant MW. The hindered transport analysis suggested an effective pore radius of 1.5 to 3 nm for the buccal membrane barrier.Apipa WanasathopPriya B PatelHyojin A. ChoiS. Kevin LiMDPI AGarticlepermeabilitybuccalmembranedrug deliverytransportPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1814, p 1814 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	permeability buccal membrane drug delivery transport Pharmacy and materia medica RS1-441
spellingShingle	permeability buccal membrane drug delivery transport Pharmacy and materia medica RS1-441 Apipa Wanasathop Priya B Patel Hyojin A. Choi S. Kevin Li Permeability of Buccal Mucosa
description	The buccal mucosa provides an alternative route of drug delivery that can be more beneficial compared to other administration routes. Although numerous studies and reviews have been published on buccal drug delivery, an extensive review of the permeability data is not available. Understanding the buccal mucosa barrier could provide insights into the approaches to effective drug delivery and optimization of dosage forms. This paper provides a review on the permeability of the buccal mucosa. The intrinsic permeability coefficients of porcine buccal mucosa were collected. Large variability was observed among the published permeability data. The permeability coefficients were then analyzed using a model involving parallel lipoidal and polar transport pathways. For the lipoidal pathway, a correlation was observed between the permeability coefficients and permeant octanol/water partition coefficients (<i>K<sub>ow</sub></i>) and molecular weight (MW) in a subset of the permeability data under specific conditions. The permeability analysis suggested that the buccal permeation barrier was less lipophilic than octanol. For the polar pathway and macromolecules, a correlation was observed between the permeability coefficients and permeant MW. The hindered transport analysis suggested an effective pore radius of 1.5 to 3 nm for the buccal membrane barrier.
format	article
author	Apipa Wanasathop Priya B Patel Hyojin A. Choi S. Kevin Li
author_facet	Apipa Wanasathop Priya B Patel Hyojin A. Choi S. Kevin Li
author_sort	Apipa Wanasathop
title	Permeability of Buccal Mucosa
title_short	Permeability of Buccal Mucosa
title_full	Permeability of Buccal Mucosa
title_fullStr	Permeability of Buccal Mucosa
title_full_unstemmed	Permeability of Buccal Mucosa
title_sort	permeability of buccal mucosa
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/2cccb91a51a34649a16f2367abb06788
work_keys_str_mv	AT apipawanasathop permeabilityofbuccalmucosa AT priyabpatel permeabilityofbuccalmucosa AT hyojinachoi permeabilityofbuccalmucosa AT skevinli permeabilityofbuccalmucosa
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Permeability of Buccal Mucosa

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