Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling

Autotaxin generates the bioactive lipid lysophosphatidic acid to regulate diverse biological processes. Here, the authors identify a role for bile salts as direct allosteric inhibitors of autotaxin activity, suggesting that steroids may function as regulators of lysophosphatidic acid signalling.

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Autores principales:	Willem-Jan Keune, Jens Hausmann, Ruth Bolier, Dagmar Tolenaars, Andreas Kremer, Tatjana Heidebrecht, Robbie P. Joosten, Manjula Sunkara, Andrew J. Morris, Elisa Matas-Rico, Wouter H. Moolenaar, Ronald P. Oude Elferink, Anastassis Perrakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ccdbeab88fd47eba8cb69bd11c92811
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spelling	oai:doaj.org-article:2ccdbeab88fd47eba8cb69bd11c928112021-12-02T16:56:45ZSteroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling10.1038/ncomms112482041-1723https://doaj.org/article/2ccdbeab88fd47eba8cb69bd11c928112016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11248https://doaj.org/toc/2041-1723Autotaxin generates the bioactive lipid lysophosphatidic acid to regulate diverse biological processes. Here, the authors identify a role for bile salts as direct allosteric inhibitors of autotaxin activity, suggesting that steroids may function as regulators of lysophosphatidic acid signalling.Willem-Jan KeuneJens HausmannRuth BolierDagmar TolenaarsAndreas KremerTatjana HeidebrechtRobbie P. JoostenManjula SunkaraAndrew J. MorrisElisa Matas-RicoWouter H. MoolenaarRonald P. Oude ElferinkAnastassis PerrakisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Willem-Jan Keune Jens Hausmann Ruth Bolier Dagmar Tolenaars Andreas Kremer Tatjana Heidebrecht Robbie P. Joosten Manjula Sunkara Andrew J. Morris Elisa Matas-Rico Wouter H. Moolenaar Ronald P. Oude Elferink Anastassis Perrakis Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
description	Autotaxin generates the bioactive lipid lysophosphatidic acid to regulate diverse biological processes. Here, the authors identify a role for bile salts as direct allosteric inhibitors of autotaxin activity, suggesting that steroids may function as regulators of lysophosphatidic acid signalling.
format	article
author	Willem-Jan Keune Jens Hausmann Ruth Bolier Dagmar Tolenaars Andreas Kremer Tatjana Heidebrecht Robbie P. Joosten Manjula Sunkara Andrew J. Morris Elisa Matas-Rico Wouter H. Moolenaar Ronald P. Oude Elferink Anastassis Perrakis
author_facet	Willem-Jan Keune Jens Hausmann Ruth Bolier Dagmar Tolenaars Andreas Kremer Tatjana Heidebrecht Robbie P. Joosten Manjula Sunkara Andrew J. Morris Elisa Matas-Rico Wouter H. Moolenaar Ronald P. Oude Elferink Anastassis Perrakis
author_sort	Willem-Jan Keune
title	Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
title_short	Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
title_full	Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
title_fullStr	Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
title_full_unstemmed	Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling
title_sort	steroid binding to autotaxin links bile salts and lysophosphatidic acid signalling
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/2ccdbeab88fd47eba8cb69bd11c92811
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Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signalling

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