HYLOGEOGRAPHY OF THE BEIJING LINEAGE IN MONGOLIA

Background. Mongolia is one of the seven countries in Western Pacific regions with high burden of tuberculosis. The earlier research indicates that there is a difference in the distribution of some epidemiologically important subtypes of the Beijing lineage in Mongolia and adjacent Russian regions....

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Autores principales:	E. A. Orlova, S. N. Zhdanova, O. B. Ogarkov, M. V. Badleeva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	m. tuberculosis phylogeography of the beijing uneage in mongolia tuberculosis beijing genotype m. tuberculosis Science Q
Acceso en línea:	https://doaj.org/article/2cce05ea2f344b599d1592234aaab67d
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spelling	oai:doaj.org-article:2cce05ea2f344b599d1592234aaab67d2021-11-23T06:14:36ZHYLOGEOGRAPHY OF THE BEIJING LINEAGE IN MONGOLIA2541-94202587-959610.12737/23413https://doaj.org/article/2cce05ea2f344b599d1592234aaab67d2016-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/298https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Mongolia is one of the seven countries in Western Pacific regions with high burden of tuberculosis. The earlier research indicates that there is a difference in the distribution of some epidemiologically important subtypes of the Beijing lineage in Mongolia and adjacent Russian regions. Aim of the research: assessment of genotypic structure of M. tuberculosis (MBT) on the border of Russia and central regions of Mongolia. Materials and methods: The DNAs of 143 clinical isolates of MBT from Russian border (46.2 %) and central (53.8 %) regions of Mongolia have been genotyped by the 24-locus MIRU-VNTR and RD105/RD207. Strains of the Beijing lineage have been analyzed additionally according to the classification by Merker et al. (2015). Results. The study of MBT in Mongolia indicates significant predominance of strains of the Beijing lineage (79.0 %) and Beijing MIT 17 subtype (72.6 %). However, the strains of the Beijing subtype W148, widespread in Irkutsk Oblast and Buryatia, have not been noted in Mongolia. According to the classification by M. Merker et al., the majority of studied strains of the Beijing lineage (85.8 %) relate to the clonal complexe CC4, infrequently detected in Russian border regions. Statistically significant differences between distribution of clonal complexes among border with Russia and central regions of Mongolia have not been detected. Conclusions. Strains of the clonal complex CC4 of Beijing lineage dominate in central and border to Russia regions of Mongolia, this allows assuming that the different geographical regions were sources of MBT strains, prevalent in Mongolia and adjacent Russian regions.E. A. OrlovaS. N. ZhdanovaO. B. OgarkovM. V. BadleevaScientific Сentre for Family Health and Human Reproduction Problemsarticlem. tuberculosis phylogeography of the beijing uneage in mongoliatuberculosisbeijing genotypem. tuberculosisScienceQRUActa Biomedica Scientifica, Vol 1, Iss 5, Pp 146-149 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	m. tuberculosis phylogeography of the beijing uneage in mongolia tuberculosis beijing genotype m. tuberculosis Science Q
spellingShingle	m. tuberculosis phylogeography of the beijing uneage in mongolia tuberculosis beijing genotype m. tuberculosis Science Q E. A. Orlova S. N. Zhdanova O. B. Ogarkov M. V. Badleeva HYLOGEOGRAPHY OF THE BEIJING LINEAGE IN MONGOLIA
description	Background. Mongolia is one of the seven countries in Western Pacific regions with high burden of tuberculosis. The earlier research indicates that there is a difference in the distribution of some epidemiologically important subtypes of the Beijing lineage in Mongolia and adjacent Russian regions. Aim of the research: assessment of genotypic structure of M. tuberculosis (MBT) on the border of Russia and central regions of Mongolia. Materials and methods: The DNAs of 143 clinical isolates of MBT from Russian border (46.2 %) and central (53.8 %) regions of Mongolia have been genotyped by the 24-locus MIRU-VNTR and RD105/RD207. Strains of the Beijing lineage have been analyzed additionally according to the classification by Merker et al. (2015). Results. The study of MBT in Mongolia indicates significant predominance of strains of the Beijing lineage (79.0 %) and Beijing MIT 17 subtype (72.6 %). However, the strains of the Beijing subtype W148, widespread in Irkutsk Oblast and Buryatia, have not been noted in Mongolia. According to the classification by M. Merker et al., the majority of studied strains of the Beijing lineage (85.8 %) relate to the clonal complexe CC4, infrequently detected in Russian border regions. Statistically significant differences between distribution of clonal complexes among border with Russia and central regions of Mongolia have not been detected. Conclusions. Strains of the clonal complex CC4 of Beijing lineage dominate in central and border to Russia regions of Mongolia, this allows assuming that the different geographical regions were sources of MBT strains, prevalent in Mongolia and adjacent Russian regions.
format	article
author	E. A. Orlova S. N. Zhdanova O. B. Ogarkov M. V. Badleeva
author_facet	E. A. Orlova S. N. Zhdanova O. B. Ogarkov M. V. Badleeva
author_sort	E. A. Orlova
title	HYLOGEOGRAPHY OF THE BEIJING LINEAGE IN MONGOLIA
title_short	HYLOGEOGRAPHY OF THE BEIJING LINEAGE IN MONGOLIA
title_full	HYLOGEOGRAPHY OF THE BEIJING LINEAGE IN MONGOLIA
title_fullStr	HYLOGEOGRAPHY OF THE BEIJING LINEAGE IN MONGOLIA
title_full_unstemmed	HYLOGEOGRAPHY OF THE BEIJING LINEAGE IN MONGOLIA
title_sort	hylogeography of the beijing lineage in mongolia
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/2cce05ea2f344b599d1592234aaab67d
work_keys_str_mv	AT eaorlova hylogeographyofthebeijinglineageinmongolia AT snzhdanova hylogeographyofthebeijinglineageinmongolia AT obogarkov hylogeographyofthebeijinglineageinmongolia AT mvbadleeva hylogeographyofthebeijinglineageinmongolia
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HYLOGEOGRAPHY OF THE BEIJING LINEAGE IN MONGOLIA

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