Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase

Bacterial phospholipases and sphingomyelinases are lipolytic esterases that are structurally and evolutionarily heterogeneous. These enzymes play crucial roles as virulence factors in several human and animal infectious diseases. Some bacterial phospholipases C (PLCs) have both phosphatidylcholinest...

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Autores principales: Laura Monturiol‐Gross, Fabian Villalta‐Romero, Marietta Flores‐Díaz, Alberto Alape‐Girón
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Publicado: Wiley 2021
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spelling oai:doaj.org-article:2ccf224eaaff4bc987167fe69d1b37dc2021-12-01T13:36:12ZBacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase2211-546310.1002/2211-5463.13320https://doaj.org/article/2ccf224eaaff4bc987167fe69d1b37dc2021-12-01T00:00:00Zhttps://doi.org/10.1002/2211-5463.13320https://doaj.org/toc/2211-5463Bacterial phospholipases and sphingomyelinases are lipolytic esterases that are structurally and evolutionarily heterogeneous. These enzymes play crucial roles as virulence factors in several human and animal infectious diseases. Some bacterial phospholipases C (PLCs) have both phosphatidylcholinesterase and sphingomyelinase C activities. Among them, Listeria monocytogenes PlcB, Clostridium perfringens PLC, and Pseudomonas aeruginosa PlcH are the most deeply understood. In silico predictions of substrates docking with these three bacterial enzymes provide evidence that they interact with different substrates at the same active site. This review discusses structural aspects, substrate specificity, and the mechanism of action of those bacterial enzymes on target cells and animal infection models to shed light on their roles in pathogenesis.Laura Monturiol‐GrossFabian Villalta‐RomeroMarietta Flores‐DíazAlberto Alape‐GirónWileyarticlebacterial pathogenesisbacterial phospholipasesbacterial sphingomyelinasesbacterial toxinsvirulence factorsBiology (General)QH301-705.5ENFEBS Open Bio, Vol 11, Iss 12, Pp 3262-3275 (2021)
institution DOAJ
collection DOAJ
language EN
topic bacterial pathogenesis
bacterial phospholipases
bacterial sphingomyelinases
bacterial toxins
virulence factors
Biology (General)
QH301-705.5
spellingShingle bacterial pathogenesis
bacterial phospholipases
bacterial sphingomyelinases
bacterial toxins
virulence factors
Biology (General)
QH301-705.5
Laura Monturiol‐Gross
Fabian Villalta‐Romero
Marietta Flores‐Díaz
Alberto Alape‐Girón
Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase
description Bacterial phospholipases and sphingomyelinases are lipolytic esterases that are structurally and evolutionarily heterogeneous. These enzymes play crucial roles as virulence factors in several human and animal infectious diseases. Some bacterial phospholipases C (PLCs) have both phosphatidylcholinesterase and sphingomyelinase C activities. Among them, Listeria monocytogenes PlcB, Clostridium perfringens PLC, and Pseudomonas aeruginosa PlcH are the most deeply understood. In silico predictions of substrates docking with these three bacterial enzymes provide evidence that they interact with different substrates at the same active site. This review discusses structural aspects, substrate specificity, and the mechanism of action of those bacterial enzymes on target cells and animal infection models to shed light on their roles in pathogenesis.
format article
author Laura Monturiol‐Gross
Fabian Villalta‐Romero
Marietta Flores‐Díaz
Alberto Alape‐Girón
author_facet Laura Monturiol‐Gross
Fabian Villalta‐Romero
Marietta Flores‐Díaz
Alberto Alape‐Girón
author_sort Laura Monturiol‐Gross
title Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase
title_short Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase
title_full Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase
title_fullStr Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase
title_full_unstemmed Bacterial phospholipases C with dual activity: phosphatidylcholinesterase and sphingomyelinase
title_sort bacterial phospholipases c with dual activity: phosphatidylcholinesterase and sphingomyelinase
publisher Wiley
publishDate 2021
url https://doaj.org/article/2ccf224eaaff4bc987167fe69d1b37dc
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AT mariettafloresdiaz bacterialphospholipasescwithdualactivityphosphatidylcholinesteraseandsphingomyelinase
AT albertoalapegiron bacterialphospholipasescwithdualactivityphosphatidylcholinesteraseandsphingomyelinase
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