Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions

Resolving nucleosomes with chemical accuracy inside sub-Mb chromatin provides molecular insight into the modulation of chromatin structure and its liquid–liquid phase separation (LLPS). By developing a multiscale chromatin model, the authors find that DNA breathing enhances the valency, heterogeneit...

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Autores principales:	Stephen E. Farr, Esmae J. Woods, Jerelle A. Joseph, Adiran Garaizar, Rosana Collepardo-Guevara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2ccf85c682384ea19befda7c7e4cab5d
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spelling	oai:doaj.org-article:2ccf85c682384ea19befda7c7e4cab5d2021-12-02T16:51:19ZNucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions10.1038/s41467-021-23090-32041-1723https://doaj.org/article/2ccf85c682384ea19befda7c7e4cab5d2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23090-3https://doaj.org/toc/2041-1723Resolving nucleosomes with chemical accuracy inside sub-Mb chromatin provides molecular insight into the modulation of chromatin structure and its liquid–liquid phase separation (LLPS). By developing a multiscale chromatin model, the authors find that DNA breathing enhances the valency, heterogeneity, and dynamics of nucleosomes, promoting disordered folding and LLPS.Stephen E. FarrEsmae J. WoodsJerelle A. JosephAdiran GaraizarRosana Collepardo-GuevaraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen E. Farr Esmae J. Woods Jerelle A. Joseph Adiran Garaizar Rosana Collepardo-Guevara Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
description	Resolving nucleosomes with chemical accuracy inside sub-Mb chromatin provides molecular insight into the modulation of chromatin structure and its liquid–liquid phase separation (LLPS). By developing a multiscale chromatin model, the authors find that DNA breathing enhances the valency, heterogeneity, and dynamics of nucleosomes, promoting disordered folding and LLPS.
format	article
author	Stephen E. Farr Esmae J. Woods Jerelle A. Joseph Adiran Garaizar Rosana Collepardo-Guevara
author_facet	Stephen E. Farr Esmae J. Woods Jerelle A. Joseph Adiran Garaizar Rosana Collepardo-Guevara
author_sort	Stephen E. Farr
title	Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
title_short	Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
title_full	Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
title_fullStr	Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
title_full_unstemmed	Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
title_sort	nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/2ccf85c682384ea19befda7c7e4cab5d
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Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions

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