Nucleosome plasticity is a critical element of chromatin liquid–liquid phase separation and multivalent nucleosome interactions

Resolving nucleosomes with chemical accuracy inside sub-Mb chromatin provides molecular insight into the modulation of chromatin structure and its liquid–liquid phase separation (LLPS). By developing a multiscale chromatin model, the authors find that DNA breathing enhances the valency, heterogeneit...

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Autores principales: Stephen E. Farr, Esmae J. Woods, Jerelle A. Joseph, Adiran Garaizar, Rosana Collepardo-Guevara
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2ccf85c682384ea19befda7c7e4cab5d
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