NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer

Splicing of the telomerase transcript, hTERT, can be altered in cancer cells. Here the authors report NOVA1, as a splicing regulator that directly interacts with hTERT pre-mRNA enhancing the number of full-length transcripts and thus telomerase activity in lung cancer cells.

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Autores principales:	Andrew T. Ludlow, Mandy Sze Wong, Jerome D. Robin, Kimberly Batten, Laura Yuan, Tsung-Po Lai, Nicole Dahlson, Lu Zhang, Ilgen Mender, Enzo Tedone, Mohammed E. Sayed, Woodring E. Wright, Jerry W. Shay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2cd190c0898f4b9ebf7b01ae510309b7
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spelling	oai:doaj.org-article:2cd190c0898f4b9ebf7b01ae510309b72021-12-02T17:32:02ZNOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer10.1038/s41467-018-05582-x2041-1723https://doaj.org/article/2cd190c0898f4b9ebf7b01ae510309b72018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05582-xhttps://doaj.org/toc/2041-1723Splicing of the telomerase transcript, hTERT, can be altered in cancer cells. Here the authors report NOVA1, as a splicing regulator that directly interacts with hTERT pre-mRNA enhancing the number of full-length transcripts and thus telomerase activity in lung cancer cells.Andrew T. LudlowMandy Sze WongJerome D. RobinKimberly BattenLaura YuanTsung-Po LaiNicole DahlsonLu ZhangIlgen MenderEnzo TedoneMohammed E. SayedWoodring E. WrightJerry W. ShayNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew T. Ludlow Mandy Sze Wong Jerome D. Robin Kimberly Batten Laura Yuan Tsung-Po Lai Nicole Dahlson Lu Zhang Ilgen Mender Enzo Tedone Mohammed E. Sayed Woodring E. Wright Jerry W. Shay NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
description	Splicing of the telomerase transcript, hTERT, can be altered in cancer cells. Here the authors report NOVA1, as a splicing regulator that directly interacts with hTERT pre-mRNA enhancing the number of full-length transcripts and thus telomerase activity in lung cancer cells.
format	article
author	Andrew T. Ludlow Mandy Sze Wong Jerome D. Robin Kimberly Batten Laura Yuan Tsung-Po Lai Nicole Dahlson Lu Zhang Ilgen Mender Enzo Tedone Mohammed E. Sayed Woodring E. Wright Jerry W. Shay
author_facet	Andrew T. Ludlow Mandy Sze Wong Jerome D. Robin Kimberly Batten Laura Yuan Tsung-Po Lai Nicole Dahlson Lu Zhang Ilgen Mender Enzo Tedone Mohammed E. Sayed Woodring E. Wright Jerry W. Shay
author_sort	Andrew T. Ludlow
title	NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
title_short	NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
title_full	NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
title_fullStr	NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
title_full_unstemmed	NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer
title_sort	nova1 regulates htert splicing and cell growth in non-small cell lung cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2cd190c0898f4b9ebf7b01ae510309b7
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NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer

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