Triiodothyronine levels were positively correlated with opening of collateral circulation in cerebral infarction patients with large artery atherosclerosis

Introduction Non-thyroidal illness syndrome (NTIS) is one of the signs for poor prognosis of cerebral infarction (CI), but its risk factors had never been explored. In this study, we analyzed the potential effect of collateral circulation on prognosis prediction of triiodothyronine for large artery...

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Autores principales:	Xiao-Feng Dong, Fan-Zhen Kong, Ming-Qiang Shen, Jiang Huang, Zong-En Gao, Qian-Zhu Guo, Zhong Zhao, Wei-Feng Luo, Qing-Zhang Cheng, Guan-Hui Wu
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	prognosis cerebral infarction collateral circulation nonthyroidal illness syndrome non-thyroidal illness syndrome Medicine R
Acceso en línea:	https://doaj.org/article/2cd2162668fe4474bebb98c7c1a66d5d
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spelling	oai:doaj.org-article:2cd2162668fe4474bebb98c7c1a66d5d2021-12-02T18:33:05ZTriiodothyronine levels were positively correlated with opening of collateral circulation in cerebral infarction patients with large artery atherosclerosis1734-19221896-915110.5114/aoms.2020.91286https://doaj.org/article/2cd2162668fe4474bebb98c7c1a66d5d2019-12-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Triiodothyronine-levels-were-positively-correlated-with-opening-of-collateral-circulation,75999,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Non-thyroidal illness syndrome (NTIS) is one of the signs for poor prognosis of cerebral infarction (CI), but its risk factors had never been explored. In this study, we analyzed the potential effect of collateral circulation on prognosis prediction of triiodothyronine for large artery atherosclerosis cerebral infarction (LAA-CI) patients. Material and methods Clinical data of CI patients between 2012 and 2014 were collected. Imaging inspection was used for determining TOAST classification and evaluating collateral circulation. One-year follow-up was conducted for mRS score by telephone. Results T3 level in the NTIS group (p = 0.001) was significantly decreased while TSH level (p < 0.001) was increased. Patients in the NTIS group had a poorer prognosis (p = 0.008) and the main reason was the high mortality (p = 0.002). NTIS predicted poor collateral circulation (p = 0.026) and good collateral circulation tended to be less likely concomitant with NTIS (p = 0.001). Logistic regression analysis showed that triiodothyronine concentrations (OR = 4.760, 95% CI: 1.981–11.456, p < 0.001) were positively correlated with but advanced age (OR = 0.756, 95% CI: 0.645–0.886, p = 0.001) negatively with opening of collateral circulation. Conclusions Poor opening of collateral circulation was likely to mediate the prediction of NTIS for prognosis of LAA-CI patients.Xiao-Feng DongFan-Zhen KongMing-Qiang ShenJiang HuangZong-En GaoQian-Zhu GuoZhong ZhaoWei-Feng LuoQing-Zhang ChengGuan-Hui WuTermedia Publishing Housearticleprognosiscerebral infarctioncollateral circulationnonthyroidal illness syndromenon-thyroidal illness syndromeMedicineRENArchives of Medical Science, Vol 16, Iss 1, Pp 51-57 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	prognosis cerebral infarction collateral circulation nonthyroidal illness syndrome non-thyroidal illness syndrome Medicine R
spellingShingle	prognosis cerebral infarction collateral circulation nonthyroidal illness syndrome non-thyroidal illness syndrome Medicine R Xiao-Feng Dong Fan-Zhen Kong Ming-Qiang Shen Jiang Huang Zong-En Gao Qian-Zhu Guo Zhong Zhao Wei-Feng Luo Qing-Zhang Cheng Guan-Hui Wu Triiodothyronine levels were positively correlated with opening of collateral circulation in cerebral infarction patients with large artery atherosclerosis
description	Introduction Non-thyroidal illness syndrome (NTIS) is one of the signs for poor prognosis of cerebral infarction (CI), but its risk factors had never been explored. In this study, we analyzed the potential effect of collateral circulation on prognosis prediction of triiodothyronine for large artery atherosclerosis cerebral infarction (LAA-CI) patients. Material and methods Clinical data of CI patients between 2012 and 2014 were collected. Imaging inspection was used for determining TOAST classification and evaluating collateral circulation. One-year follow-up was conducted for mRS score by telephone. Results T3 level in the NTIS group (p = 0.001) was significantly decreased while TSH level (p < 0.001) was increased. Patients in the NTIS group had a poorer prognosis (p = 0.008) and the main reason was the high mortality (p = 0.002). NTIS predicted poor collateral circulation (p = 0.026) and good collateral circulation tended to be less likely concomitant with NTIS (p = 0.001). Logistic regression analysis showed that triiodothyronine concentrations (OR = 4.760, 95% CI: 1.981–11.456, p < 0.001) were positively correlated with but advanced age (OR = 0.756, 95% CI: 0.645–0.886, p = 0.001) negatively with opening of collateral circulation. Conclusions Poor opening of collateral circulation was likely to mediate the prediction of NTIS for prognosis of LAA-CI patients.
format	article
author	Xiao-Feng Dong Fan-Zhen Kong Ming-Qiang Shen Jiang Huang Zong-En Gao Qian-Zhu Guo Zhong Zhao Wei-Feng Luo Qing-Zhang Cheng Guan-Hui Wu
author_facet	Xiao-Feng Dong Fan-Zhen Kong Ming-Qiang Shen Jiang Huang Zong-En Gao Qian-Zhu Guo Zhong Zhao Wei-Feng Luo Qing-Zhang Cheng Guan-Hui Wu
author_sort	Xiao-Feng Dong
title	Triiodothyronine levels were positively correlated with opening of collateral circulation in cerebral infarction patients with large artery atherosclerosis
title_short	Triiodothyronine levels were positively correlated with opening of collateral circulation in cerebral infarction patients with large artery atherosclerosis
title_full	Triiodothyronine levels were positively correlated with opening of collateral circulation in cerebral infarction patients with large artery atherosclerosis
title_fullStr	Triiodothyronine levels were positively correlated with opening of collateral circulation in cerebral infarction patients with large artery atherosclerosis
title_full_unstemmed	Triiodothyronine levels were positively correlated with opening of collateral circulation in cerebral infarction patients with large artery atherosclerosis
title_sort	triiodothyronine levels were positively correlated with opening of collateral circulation in cerebral infarction patients with large artery atherosclerosis
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/2cd2162668fe4474bebb98c7c1a66d5d
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Triiodothyronine levels were positively correlated with opening of collateral circulation in cerebral infarction patients with large artery atherosclerosis

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