A Review on Novel Drug Targets and Future Directions for COVID-19 Treatment

Yohannes Tsegyie Wondmkun,1 Ousman Ahmed Mohammed2 1Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 2College of Health Sciences, Woldia University, Woldia, EthiopiaCorrespondence: Yohannes Tsegyie Wondmk...

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Autores principales:	Wondmkun YT, Mohammed OA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	covid-19 drug targets sars-cov-2 non-structural proteins structural proteins Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2cd4d2d36be74a87baaf5d0689cfa644
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spelling	oai:doaj.org-article:2cd4d2d36be74a87baaf5d0689cfa6442021-12-02T13:12:54ZA Review on Novel Drug Targets and Future Directions for COVID-19 Treatment1177-5491https://doaj.org/article/2cd4d2d36be74a87baaf5d0689cfa6442020-08-01T00:00:00Zhttps://www.dovepress.com/a-review-on-novel-drug-targets-and-future-directions-for-covid-19-trea-peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491Yohannes Tsegyie Wondmkun,1 Ousman Ahmed Mohammed2 1Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 2College of Health Sciences, Woldia University, Woldia, EthiopiaCorrespondence: Yohannes Tsegyie WondmkunDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Churchill Avenue, P.O. Box 1176, Addis Ababa, EthiopiaEmail yohannes.tsegyie@aau.edu.etAbstract: Severe acute respiratory syndrome coronavirus-2 causes coronavirus disease-19 (COVID-19) that spreads quickly in the world. Considering the impact of this pandemic, researchers have been racing to understand the peculiar nature of the virus and the pathogenesis of the disease to uncover possible drug targets, effective therapeutic agents, and vaccines. Accordingly, numerous drug targets are identified by scientists. Among them, structural glycoproteins, virulence factors, host-specific receptors and enzymes, non-structure proteins, the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway, and pro-inflammatory cytokines are discussed herein. This review summarizes the promising drug targets for COVID-19, and highlights antiviral strategies which depend on molecular interactions between viral small molecules and host biologic machinery for repurposing the available clinical drugs. In addition, it gives a strong rational basis for the ongoing discovery of new drugs and vaccines.Keywords: COVID-19, drug targets, SARS-COV-2, non-structural proteins, structural proteinsWondmkun YTMohammed OADove Medical Pressarticlecovid-19drug targetssars-cov-2non-structural proteinsstructural proteinsMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 14, Pp 77-82 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 drug targets sars-cov-2 non-structural proteins structural proteins Medicine (General) R5-920
spellingShingle	covid-19 drug targets sars-cov-2 non-structural proteins structural proteins Medicine (General) R5-920 Wondmkun YT Mohammed OA A Review on Novel Drug Targets and Future Directions for COVID-19 Treatment
description	Yohannes Tsegyie Wondmkun,1 Ousman Ahmed Mohammed2 1Department of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia; 2College of Health Sciences, Woldia University, Woldia, EthiopiaCorrespondence: Yohannes Tsegyie WondmkunDepartment of Pharmacology and Clinical Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Churchill Avenue, P.O. Box 1176, Addis Ababa, EthiopiaEmail yohannes.tsegyie@aau.edu.etAbstract: Severe acute respiratory syndrome coronavirus-2 causes coronavirus disease-19 (COVID-19) that spreads quickly in the world. Considering the impact of this pandemic, researchers have been racing to understand the peculiar nature of the virus and the pathogenesis of the disease to uncover possible drug targets, effective therapeutic agents, and vaccines. Accordingly, numerous drug targets are identified by scientists. Among them, structural glycoproteins, virulence factors, host-specific receptors and enzymes, non-structure proteins, the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway, and pro-inflammatory cytokines are discussed herein. This review summarizes the promising drug targets for COVID-19, and highlights antiviral strategies which depend on molecular interactions between viral small molecules and host biologic machinery for repurposing the available clinical drugs. In addition, it gives a strong rational basis for the ongoing discovery of new drugs and vaccines.Keywords: COVID-19, drug targets, SARS-COV-2, non-structural proteins, structural proteins
format	article
author	Wondmkun YT Mohammed OA
author_facet	Wondmkun YT Mohammed OA
author_sort	Wondmkun YT
title	A Review on Novel Drug Targets and Future Directions for COVID-19 Treatment
title_short	A Review on Novel Drug Targets and Future Directions for COVID-19 Treatment
title_full	A Review on Novel Drug Targets and Future Directions for COVID-19 Treatment
title_fullStr	A Review on Novel Drug Targets and Future Directions for COVID-19 Treatment
title_full_unstemmed	A Review on Novel Drug Targets and Future Directions for COVID-19 Treatment
title_sort	review on novel drug targets and future directions for covid-19 treatment
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/2cd4d2d36be74a87baaf5d0689cfa644
work_keys_str_mv	AT wondmkunyt areviewonnoveldrugtargetsandfuturedirectionsforcovid19treatment AT mohammedoa areviewonnoveldrugtargetsandfuturedirectionsforcovid19treatment AT wondmkunyt reviewonnoveldrugtargetsandfuturedirectionsforcovid19treatment AT mohammedoa reviewonnoveldrugtargetsandfuturedirectionsforcovid19treatment
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A Review on Novel Drug Targets and Future Directions for COVID-19 Treatment

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