The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1
Macrophage-expressed gene 1 (MPEG1) functions within the phagolysosome to damage engulfed microbes, presumably via forming pores in target membranes. In order to provide insights into the mechanism of MPEG1 function and membrane binding, the authors present structures of hexadecameric MPEG1 prepores...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/2cd82268e003405ba51038290da8f4fe |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:2cd82268e003405ba51038290da8f4fe |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:2cd82268e003405ba51038290da8f4fe2021-12-02T14:38:37ZThe cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 110.1038/s41467-019-12279-22041-1723https://doaj.org/article/2cd82268e003405ba51038290da8f4fe2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12279-2https://doaj.org/toc/2041-1723Macrophage-expressed gene 1 (MPEG1) functions within the phagolysosome to damage engulfed microbes, presumably via forming pores in target membranes. In order to provide insights into the mechanism of MPEG1 function and membrane binding, the authors present structures of hexadecameric MPEG1 prepores both in solution and in complex with liposomes.Siew Siew PangCharles Bayly-JonesMazdak RadjainiaBradley A. SpicerRuby H. P. LawAdrian W. HodelEdward S. ParsonsSusan M. EkkelPaul J. ConroyGeorg RammHariprasad VenugopalPhillip I. BirdBart W. HoogenboomIlia VoskoboinikYann GambinEmma SiereckiMichelle A. DunstoneJames C. WhisstockNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Siew Siew Pang Charles Bayly-Jones Mazdak Radjainia Bradley A. Spicer Ruby H. P. Law Adrian W. Hodel Edward S. Parsons Susan M. Ekkel Paul J. Conroy Georg Ramm Hariprasad Venugopal Phillip I. Bird Bart W. Hoogenboom Ilia Voskoboinik Yann Gambin Emma Sierecki Michelle A. Dunstone James C. Whisstock The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1 |
| description |
Macrophage-expressed gene 1 (MPEG1) functions within the phagolysosome to damage engulfed microbes, presumably via forming pores in target membranes. In order to provide insights into the mechanism of MPEG1 function and membrane binding, the authors present structures of hexadecameric MPEG1 prepores both in solution and in complex with liposomes. |
| format |
article |
| author |
Siew Siew Pang Charles Bayly-Jones Mazdak Radjainia Bradley A. Spicer Ruby H. P. Law Adrian W. Hodel Edward S. Parsons Susan M. Ekkel Paul J. Conroy Georg Ramm Hariprasad Venugopal Phillip I. Bird Bart W. Hoogenboom Ilia Voskoboinik Yann Gambin Emma Sierecki Michelle A. Dunstone James C. Whisstock |
| author_facet |
Siew Siew Pang Charles Bayly-Jones Mazdak Radjainia Bradley A. Spicer Ruby H. P. Law Adrian W. Hodel Edward S. Parsons Susan M. Ekkel Paul J. Conroy Georg Ramm Hariprasad Venugopal Phillip I. Bird Bart W. Hoogenboom Ilia Voskoboinik Yann Gambin Emma Sierecki Michelle A. Dunstone James C. Whisstock |
| author_sort |
Siew Siew Pang |
| title |
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1 |
| title_short |
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1 |
| title_full |
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1 |
| title_fullStr |
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1 |
| title_full_unstemmed |
The cryo-EM structure of the acid activatable pore-forming immune effector Macrophage-expressed gene 1 |
| title_sort |
cryo-em structure of the acid activatable pore-forming immune effector macrophage-expressed gene 1 |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/2cd82268e003405ba51038290da8f4fe |
| work_keys_str_mv |
AT siewsiewpang thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT charlesbaylyjones thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT mazdakradjainia thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT bradleyaspicer thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT rubyhplaw thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT adrianwhodel thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT edwardsparsons thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT susanmekkel thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT pauljconroy thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT georgramm thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT hariprasadvenugopal thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT phillipibird thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT bartwhoogenboom thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT iliavoskoboinik thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT yanngambin thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT emmasierecki thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT michelleadunstone thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT jamescwhisstock thecryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT siewsiewpang cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT charlesbaylyjones cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT mazdakradjainia cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT bradleyaspicer cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT rubyhplaw cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT adrianwhodel cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT edwardsparsons cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT susanmekkel cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT pauljconroy cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT georgramm cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT hariprasadvenugopal cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT phillipibird cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT bartwhoogenboom cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT iliavoskoboinik cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT yanngambin cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT emmasierecki cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT michelleadunstone cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 AT jamescwhisstock cryoemstructureoftheacidactivatableporeformingimmuneeffectormacrophageexpressedgene1 |
| _version_ |
1718390941456269312 |